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Yuyu Niu
Kunming University of Science and Technology
52Publications
15H-index
1,535Citations
Publications 52
Newest
#1Chu Chu (Kunming University of Science and Technology)H-Index: 1
#2Zhaohui Yang (Kunming University of Science and Technology)H-Index: 1
Last.Yuyu Niu (Kunming University of Science and Technology)H-Index: 15
view all 10 authors...
Background Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision and efficiency offered by engineered site-specific endonuclease-based systems, such as transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) system. It has been demonst...
#1Yu Kang (Kunming University of Science and Technology)
#2Chu Chu (Kunming University of Science and Technology)
Last.Yuyu Niu (Kunming University of Science and Technology)H-Index: 15
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ABSTRACT Owing to their high similarity to humans, non-human primates (NHPs) provide an exceedingly suitable model for the study of human disease. In this Review, we summarize the history of transgenic NHP models and the progress of CRISPR/Cas9-mediated genome editing in NHPs, from the first proof-of-principle green fluorescent protein-expressing monkeys to sophisticated NHP models of human neurodegenerative disease that accurately phenocopy several complex disease features. We discuss not only ...
#1Dayong Wang (UMMS: University of Massachusetts Medical School)H-Index: 79
#2Yuyu Niu (Kunming University of Science and Technology)H-Index: 15
Last.Weizhi Ji (Kunming University of Science and Technology)H-Index: 23
view all 10 authors...
#1Bo Zhang (Kunming University of Science and Technology)
#2Zhigang Zhou (Kunming University of Science and Technology)H-Index: 1
Last.Yongchang Chen (Kunming University of Science and Technology)H-Index: 11
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#1Lei Shi (KIZ: Kunming Institute of Zoology)H-Index: 9
#2Xin LuoH-Index: 1
Last.Yanjiao Li (KIZ: Kunming Institute of Zoology)H-Index: 1
view all 20 authors...
#1Yongchang Chen (Kunming University of Science and Technology)H-Index: 11
#2Puhao Xiao (Kunming University of Science and Technology)H-Index: 1
Last.Shuaiwei Ren (Kunming University of Science and Technology)H-Index: 1
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The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem that cannot be ignored, especially for in vivo gene correction. Non-human primates...
#1Li Yan (UM: University of Macau)H-Index: 3
#2Bin Jiang (UM: University of Macau)H-Index: 4
Last.Guokai Chen (UM: University of Macau)H-Index: 14
view all 13 authors...
Nonhuman primate experimental autoimmune encephalomyelitis (EAE) is a valuable model for multiple sclerosis, an inflammatory demyelinating disease in the central nervous system (CNS). Human embryonic stem cell-derived mesenchymal stem cells (EMSC) are effective in treating murine EAE. Yet, it remains unknown whether the EMSC efficacy is translatable to humans. Here we induced a primate EAE model in cynomolgus monkeys and delivered EMSC in spheres (EMSCsp) to preserve the cell viability during lo...
#1Yu Kang (Kunming University of Science and Technology)H-Index: 8
#2Zongyong Ai (Kunming University of Science and Technology)H-Index: 5
Last.Baohua Niu (Kunming University of Science and Technology)H-Index: 1
view all 17 authors...
Summary Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injected morulae are cultured, we observed increased survival of cynomolgus monkey primed ESCs, induced PSCs, and somatic cell nuclear transfer-derived ESCs, thereby enabling chime...
#1Shuang Wang (Kunming University of Science and Technology)H-Index: 2
#2Shuaiwei Ren (Kunming University of Science and Technology)H-Index: 1
Last.Yongchang Chen (Kunming University of Science and Technology)H-Index: 11
view all 10 authors...
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