Yuyu Niu
Kunming University of Science and Technology
53Publications
15H-index
1,483Citations
Publications 53
Newest
Published on Mar 25, 2019in bioRxiv
Yongchang Chen12
Estimated H-index: 12
(Kunming University of Science and Technology),
Puhao Xiao1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 12 AuthorsShuaiwei Ren1
Estimated H-index: 1
(Kunming University of Science and Technology)
The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem that cannot be ignored, especially for in vivo gene correction. Non-human primates...
Source Cite
Published on Jan 15, 2019in BMC Biotechnology 2.60
Chu Chu1
Estimated H-index: 1
(Kunming University of Science and Technology),
Zhaohui Yang1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 7 AuthorsYuyu Niu15
Estimated H-index: 15
(Kunming University of Science and Technology)
Background Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision and efficiency offered by engineered site-specific endonuclease-based systems, such as transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) system. It has been demonst...
Source Cite
Published on Mar 27, 2019in National Science Review 9.41
Lei Shi9
Estimated H-index: 9
(Kunming Institute of Zoology),
Xin Luo1
Estimated H-index: 1
+ 17 AuthorsJun Huang (Kunming Institute of Zoology)
Source Cite
Published on Mar 1, 2018in Cell Research 15.39
Yiqiang Cui9
Estimated H-index: 9
,
Yuyu Niu15
Estimated H-index: 15
+ 12 AuthorsBo Zheng8
Estimated H-index: 8
Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination
9 Citations Source Cite
Published on Nov 1, 2018in Cell Reports 8.03
Yu Kang8
Estimated H-index: 8
(Kunming University of Science and Technology),
Zongyong Ai5
Estimated H-index: 5
(Kunming University of Science and Technology)
+ 14 AuthorsBaohua Niu (Kunming University of Science and Technology)
Summary Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injected morulae are cultured, we observed increased survival of cynomolgus monkey primed ESCs, induced PSCs, and somatic cell nuclear transfer-derived ESCs, thereby enabling chime...
Source Cite
Published on Jul 27, 2018in Journal of Biological Chemistry 4.01
Shuang Wang2
Estimated H-index: 2
(Kunming University of Science and Technology),
Shuaiwei Ren1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 7 AuthorsYongchang Chen12
Estimated H-index: 12
(Kunming University of Science and Technology)
4 Citations Source Cite
Published on Dec 1, 2018in Cell death discovery
Li Yan3
Estimated H-index: 3
(University of Macau),
Bin Jiang4
Estimated H-index: 4
(University of Macau)
+ 10 AuthorsGuokai Chen14
Estimated H-index: 14
(University of Macau)
Nonhuman primate experimental autoimmune encephalomyelitis (EAE) is a valuable model for multiple sclerosis, an inflammatory demyelinating disease in the central nervous system (CNS). Human embryonic stem cell-derived mesenchymal stem cells (EMSC) are effective in treating murine EAE. Yet, it remains unknown whether the EMSC efficacy is translatable to humans. Here we induced a primate EAE model in cynomolgus monkeys and delivered EMSC in spheres (EMSCsp) to preserve the cell viability during lo...
1 Citations Source Cite
Published on May 3, 2018in Cell Cycle 3.30
Shuang Wang2
Estimated H-index: 2
(Kunming University of Science and Technology),
Lichuan Yang (Kunming Institute of Zoology)+ 5 AuthorsYongchang Chen12
Estimated H-index: 12
(Kunming University of Science and Technology)
ABSTRACTThe tumor suppressor p53 is a key regulator of cell apoptosis and cell cycle arrest. Recent studies show that the delicate balance of p53 expression is important for neural tube defects, neuronal degeneration, embryonic lethality, as well as differentiation and dedifferentiation. Moreover, p53 showed different regulatory patterns between rodent and primate embryonic stem cells (ESCs). However, the role of p53 and apoptosis stimulating protein of p53 (ASPP) during neural differentiation (...
Source Cite
Published on Nov 1, 2017in Biology of Reproduction 3.18
Zhou Y , Kang Y + 10 AuthorsWeizhi Ji24
Estimated H-index: 24
Source Cite
Published on Apr 1, 2017in Cell Research 15.39
Fei Gao11
Estimated H-index: 11
,
Yuyu Niu15
Estimated H-index: 15
+ 13 AuthorsJuehua Yu12
Estimated H-index: 12
Abstract Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-genome bisulfite sequencing method. We show that upon fertilization, both paternal and maternal genomes undergo active DNA demethylation, and genome-wide de novo DNA methylatio...
10 Citations Source Cite
123456