Match!
Phillip W. Baker
University of New Mexico
6Publications
5H-index
160Citations
Publications 6
Newest
#1Julie AgapiteH-Index: 1
view all 10 authors...
Source
#1Jim Thurmond (IU: Indiana University Bloomington)H-Index: 5
#2Joshua L. Goodman (IU: Indiana University Bloomington)H-Index: 6
Last.Phillip W. BakerH-Index: 5
view all 40 authors...
71 CitationsSource
#1Anton L. Bryantsev (UNM: University of New Mexico)H-Index: 13
#2Phillip W. Baker (UNM: University of New Mexico)H-Index: 5
Last.Richard M. Cripps (UNM: University of New Mexico)H-Index: 23
view all 5 authors...
Identifying the genetic program that leads to formation of functionally and morphologically distinct muscle fibers is one of the major challenges in developmental biology. In Drosophila, the Myocyte Enhancer Factor-2 (MEF2) transcription factor is important for all types of embryonic muscle differentiation. In this study we investigated the role of MEF2 at different stages of adult skeletal muscle formation, where a diverse group of specialized muscles arises. Through stage- and tissue-specific ...
38 CitationsSource
#1TyAnna L. Lovato (UNM: University of New Mexico)H-Index: 11
#2Melanie M. Adams (UNM: University of New Mexico)H-Index: 2
Last.Richard M. Cripps (UNM: University of New Mexico)H-Index: 23
view all 4 authors...
Temperature-sensitive (TS) mutations are a useful tool for elucidating gene function where a gene of interest is essential at multiple stages of development. However, the molecular mechanisms behind TS alleles vary. TS mutations of the myogenic regulator Myocyte enhancer factor-2 (MEF2) in Drosophila arise in the heteroallelic combination Mef230-5/Mef244-5. We show that the 30-5 mutation affects the N-terminal MADS domain, causing impaired DNA binding ability and failure of homozygous mutants to...
10 CitationsSource
#1Phillip W. Baker (UNM: University of New Mexico)H-Index: 5
#2Kathleen K. Kelly Tanaka (UNM: University of New Mexico)H-Index: 3
Last.Richard M. Cripps (UNM: University of New Mexico)H-Index: 23
view all 4 authors...
Myocyte enhancer factor-2 (MEF2) is a transcription factor that is necessary for embryonic muscle development in Drosophila and vertebrates; however, whether this factor is required during later muscle development remains largely unknown. Using heteroallelic combinations of different Mef2 mutant alleles, we isolated and characterized a temperature-sensitive combination. Through temperature-shift experiments, we obtained adult animals that were lacking proper MEF2 function. Many of these individu...
21 CitationsSource
#1TyAnna L. Lovato (UNM: University of New Mexico)H-Index: 11
#2S. M. Meadows (UNM: University of New Mexico)H-Index: 1
Last.Richard M. Cripps (UNM: University of New Mexico)H-Index: 23
view all 5 authors...
Actin is a ubiquitous and highly conserved eukaryotic protein required for cell motility and locomotion. In this manuscript, we characterize the four muscle actin genes of the insect Drosophila virilis and demonstrate strong similarities between the D. virilis genes and their homologues in Drosophila melanogaster ; intron locations are conserved, and there are few amino acid differences between homologues. We also found strong conservation in temporal expression patterns of the muscle actin gene...
20 CitationsSource
1