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Qing Li
Shenyang Pharmaceutical University
126Publications
18H-index
1,041Citations
Publications 126
Newest
#1Bolin Zhu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Shuang Li (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last.Xingjie Guo (SPU: Shenyang Pharmaceutical University)H-Index: 10
view all 5 authors...
Abstract In stock farming, illegal use of antipsychotics has caused the food safety problem. This paper presents for the first time, a multi-residues method for the simultaneous enantioselective determination of seven antipsychotics in pork, beef and lamb muscles. The behaviors of Chiralpak AGP toward changes in pH and organic modifier in mobile phase were studied, and all analytes were rapidly separated within 30 min. The calibration curves of all enantiomers were linear in the range of 1-250 n...
#1Bolin Zhu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Liangzhao Cai (SPU: Shenyang Pharmaceutical University)
Last.Xingjie Guo (SPU: Shenyang Pharmaceutical University)H-Index: 10
view all 5 authors...
Abstract This paper presents the stereoselective multi-residue analysis of seven β-agonists including salbutamol, clorprenaline, terbutaline, tulobuterol, metaproterenol, cimaterol and formoterol in pork muscles by chiral UPLC-MS/MS. The simultaneous enantioseparation of seven analytes was accomplished on a teicoplanin aglycone-based Astec Chirobiotic TAG column under isocratic condition at a flow rate of 0.6 mL min −1 . The effects of the mobile phase composition, the type and content of the or...
#1Bolin Zhu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Mengyao Xue (SPU: Shenyang Pharmaceutical University)
Last.Xingjie Guo (SPU: Shenyang Pharmaceutical University)H-Index: 10
view all 0 authors...
Abstract In the present paper, a sensitive and selective chiral LC method has been developed for enantiomeric separation and determination of eight antihistamines in pharmaceutical formulations. Enantiomeric separation was achieved on the α1-acid glycoprotein-based chiral stationary phase known as Chiralpak AGP. The effects of the mobile phase composition, type and proportion of organic modifier and the concentration and pH of the buffer on retention and resolution were fully investigated. All e...
#1Song Cang (SPU: Shenyang Pharmaceutical University)
#2Ran Liu (SPU: Shenyang Pharmaceutical University)H-Index: 10
Last.Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 18
view all 7 authors...
Abstract Non-small cell lung cancer (NSCLC), as the most common histological type of lung cancer with high mortality rates, has been widely treated by Compound Kushen Injection (CKI) in China. Among various active components with many pharmacologic properties, matrine, oxymatrine, sophoridine, oxysophocarpine and N-methylcytisine, are the main bioactive alkaloids of CKI. Therefore, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously quantify the fiv...
#1Yiwen Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Xinyan Lv (SPU: Shenyang Pharmaceutical University)
Last.Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 28
view all 10 authors...
Abstract Traditional Chinese Medicines (TCMs) have been widely used in orient countries for thousands of years, while their inconsistent quality and therapy issues have become increasingly serious as a result of the absence of effective methods for quality control. Therefore, it is necessary to develop a novel and specific evaluation system for TCMs’ quality involved with not only composition but also bioactivity. In this study, we used Schisandra chinensis (Turcz.) Baill as an example and devel...
#1Song Lin (SPU: Shenyang Pharmaceutical University)
#2Tianyang Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last.Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 28
view all 8 authors...
Abstract The pathology of cholestatic liver injury (CLI) was complicated, which has limited the development of anti-cholestatic drugs for a long period. Metabolomic researches focused on global and dynamic changes of the organism could shed some light on mechanism investigation. In order to characterize and validate metabolite alterations of alpha-naphthylisothiocyanate (ANIT) induced CLI in C57BL/6 mice, a systemic metabolomic approach combining nontargeted HPLC-ESI-QTOF-MS and targeted UFLC-ES...
#1Weiwei Rong (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Kewen Ding (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last.Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 28
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Abstract The promising effect of Xanthoceras sorbifolia Bunge husks against Alzheimer's disease has attracted more and more attention; however, its therapeutic mechanism has been unclear. A metabolomics study of the husks on rat serum and brain was carried out. Cognitive impairment of rats was induced by D-galactose and amyloid β, and the result was evaluated by Morris water maze test and brain histological analysis. The metabolite profiling was performed through ultra-high-performance liquid ch...
#1Sirui Guo (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Jiahong Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last.Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 18
view all 10 authors...
Alzheimer’s disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in Bei Ji Qian Jin Yao Fang and applied...
#1Wenling Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xiaomei Yang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last.Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 28
view all 9 authors...
Abstract Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two comp...
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