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Qing Li
Shenyang Pharmaceutical University
Analytical chemistryMass spectrometryHigh-performance liquid chromatographyChemistryChromatography
147Publications
20H-index
1,383Citations
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Publications 155
Newest
#1Wenhua Zhang (SPU: Shenyang Pharmaceutical University)
#2Xiuli Sun (SPU: Shenyang Pharmaceutical University)
Last. Wenchuan Bi (SZU: Shenzhen University)H-Index: 1
view all 11 authors...
Xiebai San (XBS) is a classical herbal prescription which has been used for the treatment of infantile cough and asthma for several hundred years. In this study, 39 compounds in XBS standard decoction were identified by HPLC–ESI–TOF system. Network pharmacology strategy was adopted to explore the relationship of chemicals, target genes and pathways, mulberroside A, kukoamine B and glycyrrhizic acid were chosen as quality markers in XBS standard decoction. An ultra-high-performance liquid chromat...
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#1Huarong Xu (SPU: Shenyang Pharmaceutical University)H-Index: 11
#2Jiameng Qu (SPU: Shenyang Pharmaceutical University)
Last. Ran Liu (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 7 authors...
Abstract Pulmonary fibrosis (PF) is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2–3 years. The inhibition of TGF-β receptor type-I (TGF-β RI) by an appropriate drug may provide a promising strategy for the treatment of this disease. Polygonum cuspidatum (PC) is a well-known traditional Chinese herbal medicine which has an anti-PF effect. Accordingly, a combination of high resolution mass spectrometry and an in silico strategy wa...
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#1Yue Wang (SPU: Shenyang Pharmaceutical University)
#2Yangyu Li (SPU: Shenyang Pharmaceutical University)
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 20
view all 9 authors...
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#1Qian Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Ran Liu (SPU: Shenyang Pharmaceutical University)H-Index: 12
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 20
view all 10 authors...
Abstract Quantitative determination of endogenous compounds in biological samples has still been challenged by the absence of authentic blank matrix. Alternative strategy of surrogate matrix for preparing reference samples are prevalent due to its low cost and high availability. However, the evaluation system of surrogate matrix is not perfect. Herein, a novel multifunctional isotopic standards based steroidomics strategy was developed. Isotope-labeled standards were used not only as internal st...
1 CitationsSource
#1Yiwen Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xinyan Lv (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 29
view all 11 authors...
Abstract Schisandra chinensis, a widely used Chinese herbal medicine, was considered as central nervous system (CNS) drug for years. Both ethanol extracts (EES) and water extracts (WES) of it were applied clinically. Unfortunately, the difference of their efficacy and even effective material foundation of S. chinensis remains obscure. In this study, to explore the active constituents of S. chinensis, we compared pharmacodynamics and chemical profiles in vitro/in vivo of EES/WES for the first tim...
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#1Yiyang Du (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Bo Wu (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Bosai He (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 8 authors...
Insomnia is a common clinical disease that can seriously damage the normal lives of sufferers. Suan-Zao-Ren decoction has been used to treat insomnia for a long time. However, the underlying molecular mechanism of Suan-Zao-Ren decoction is still not clear. In this study, the nontargeted metabolomics based on high-resolution mass spectrometry and multiple statistical approaches were initially used to investigate the changes of potential serum and brain biomarkers and metabolic pathways in the ins...
1 CitationsSource
#1Tianyang Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Song Lin (Qiqihar Medical University)
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 29
view all 9 authors...
Acute lung injury (ALI) is a clinically common and serious disease, underscoring the urgent need for clarification of its pathogenesis. According to traditional Chinese medicine (TCM) theories on the “lung–spleen–intestine axis” and its correlation with ALI, a high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (HPLC–QTOF-MS) metabolomic platform was applied to identify biomarkers from five bio-samples of control and model rats challenged with intratracheally admin...
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#1Sirui Guo (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Jiahong Wang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 20
view all 7 authors...
Kai-Xin-San (KXS), a classical Chinese traditional prescription, was widely applied in the treatment of Alzheimer’s disease (AD), while its functional mechanisms still remain unclear. By using systems biology approaches at animal, cellular, and molecular levels, the improvement of KXS on cognitive impairment was achieved by inhibiting abnormal acetylcholinesterase. The function on the nerve skeleton was performed by regulating the Tau phosphorylation pathway. Its antioxidant, anti-inflammatory, ...
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#1Bolin Zhu (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Shuang Li (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Xingjie Guo (SPU: Shenyang Pharmaceutical University)H-Index: 9
view all 5 authors...
Abstract In stock farming, illegal use of antipsychotics has caused the food safety problem. This paper presents for the first time, a multi-residues method for the simultaneous enantioselective determination of seven antipsychotics in pork, beef and lamb muscles. The behaviors of Chiralpak AGP toward changes in pH and organic modifier in mobile phase were studied, and all analytes were rapidly separated within 30 min. The calibration curves of all enantiomers were linear in the range of 1–250 n...
1 CitationsSource
#1Di Wang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 20
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 29
view all 8 authors...
Abstract A sensitive, fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae (SZS) standard decoction with characterization of its chemical components was developed and validated. UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides, phenolic acids, alkaloids, and flavonoids. Furthermore, a UPLC-PDA method was validated to simultaneously determine adenosine, protocatechuic acid, magnoflorine, ...
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