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Richa Sharma
Indiana University
6Publications
2H-index
8Citations
Publications 7
Newest
#1Richa SharmaH-Index: 2
#2Jesse MerH-Index: 1
Last.Terry A. Vik (IU: Indiana University)H-Index: 17
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1. Richa Sharma, MD* 2. Jesse Mer, MD† 3. Alex Lion, DO MPH‡ 4. Terry A. Vik, MD‡ 1. *Department of Pediatrics; 2. †Department of Radiology; 3. ‡Department of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN * Abbreviations: CBC: : complete blood cell CT: : computed tomography HVA: : homovanillic acid IHC: : immunohistochemical IL-2: : interleukin-2 mIBG I-123: : metaiodobenzylguanidine MRI: : magnetic resonance imaging OMS: : opsoclo...
1 CitationsSource
#1Richa Sharma (IU: Indiana University)H-Index: 2
#2Elizabeth Sierra Potchanant (IU: Indiana University)H-Index: 2
Last.Grzegorz Nalepa (IU: Indiana University)H-Index: 20
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Diagnosis of bone marrow failure (BMF) disorders is challenging but essential for optimal patient management. Here, we report a young adult from nonconsanguineous parents with progressive pancytopenia since childhood, bone pain, increased bone density, and haphazard ossification replacing hematopoiesis within the bone marrow. Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicte...
1 CitationsSource
Source
#1Richa Sharma (IU: Indiana University)H-Index: 2
#2Jennifer E. Schwartz (IU: Indiana University)H-Index: 7
Last.Grzegorz Nalepa (IU: Indiana University)H-Index: 20
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Non-dysmorphic 32-year old Caucasian female developed malaise, fluctuating body aches and progressive transfusion-dependent pancytopenia with peripheral blood morphology consistent with myelodysplastic syndrome (MDS). Reportedly, she had an episode of "low blood counts" of unclear etiology 23 years prior. Multiple attempts at bone marrow biopsy were unsuccessful due to technical difficulties with penetrating the bone, necessitating surgical biopsy by an orthopedic surgeon. Bone densitometry reve...
Source
#1Jessica Martin (IU: Indiana University)H-Index: 2
#2Richa Sharma (IU: Indiana University)H-Index: 2
Last.Jennifer Weida (IU: Indiana University)H-Index: 2
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ABSTRACTBackground: The cause of primary immunodeficiency has expanded to nearly 200 distinct disorders. An improved understanding of these disorders has resulted in decreased morbidity and mortality with reciprocal improved life expectancy. Obstetricians should have knowledge of primary immunodeficiency, as more women with these disorders will reach reproductive age. Case: 21-year-old G1P0 with purine nucleoside phosphorylase (PNP) deficiency delivered a viable infant vaginally at 37 weeks. Alt...
2 CitationsSource
#1Richa Sharma (IU: Indiana University)H-Index: 2
#2Grzegorz Nalepa (IU: Indiana University)H-Index: 20
1. Richa Sharma, MD* 2. Grzegorz Nalepa, MD, PhD*,† 1. *Department of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN. 2. †Department of Medical and Molecular Genetics and Department of Biochemistry, Indiana University School of Medicine; Bone Marrow Failure Program, Riley Hospital for Children at IU Health, Indianapolis, IN. Diagnostic evaluation and management of children with chronic pancytopenia is highly complex. (1)(2)(3) Clini...
4 CitationsSource
#1Richa Sharma (IU: Indiana University)H-Index: 2
#2Zahi Abdul Sater (IU: Indiana University)H-Index: 1
Last.Grzegorz Nalepa (IU: Indiana University)H-Index: 20
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Fanconi anemia (FA) is a genetic disorder characterized by progressive bone marrow failure, congenital abnormalities and predilection towards development of hematopoietic malignancies, including acute myeloid leukemia (AML). Congenital biallelic disruption of the FA/BRCA signaling network causes Fanconi anemia and somatic mutations within the same genes are increasingly identified in a variety of malignancies in non-FA individuals, consistent with the critical role of this signaling pathway in F...
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