Vegard Eldholm
Norwegian Institute of Public Health
Publications 42
#1Tyler S. Brown (Columbia University)H-Index: 6
#2Lavanya Challagundla (UMMC: University of Mississippi Medical Center)H-Index: 3
Last.Barun Mathema (Columbia University)H-Index: 34
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Antimicrobial-resistant (AMR) infections pose a major threat to global public health. Similar to other AMR pathogens, both historical and ongoing drug-resistant tuberculosis (TB) epidemics are characterized by transmission of a limited number of predominant Mycobacterium tuberculosis (Mtb) strains. Understanding how these predominant strains achieve sustained transmission, particularly during the critical period before they are detected via clinical or public health surveillance, can inform stra...
#1Johana MonteserinH-Index: 6
#2Laura Pérez-Lago (Hospital General Universitario Gregorio Marañón)H-Index: 9
Last.Viviana RitaccoH-Index: 27
view all 10 authors...
#2Géraldine Piorkowski (AMU: Aix-Marseille University)H-Index: 11
Last.Audrey Dubot-Pérès (AMU: Aix-Marseille University)H-Index: 10
view all 12 authors...
Abstract Determining the aetiological basis of central nervous system (CNS) infections is inherently challenging, primarily due to the multi-aetiological nature. Using RNA sequencing, we aimed to identify microbes present in cerebrospinal fluid (CSF) of two patients suffering CNS infection, previously diagnosed with Cryptococcus sp. and Streptococcus pneumoniae infection, respectively. After meta-transcriptomic analysis, and confirmation with real-time PCR, hepatitis B virus (HBV) was detected i...
#1Ola Brønstad Brynildsrud (FHI: Norwegian Institute of Public Health)H-Index: 12
#2Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Dominique A. Caugant (University of Oslo)H-Index: 54
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Neisseria meningitidis colonizes the human oropharynx and transmits mainly via asymptomatic carriage. Actual outbreaks of meningococcal meningitis are comparatively rare and occur when susceptible populations are exposed to hypervirulent clones, genetically distinct from the main carriage isolates. However, carriage isolates can evolve into pathogens through a limited number of recombination events. The present study examines the potential for the sequence type (ST)-192, by far the dominant clon...
#1Lucy van Dorp (UCL: University College London)H-Index: 9
#2Qi Wang (PKU: Peking University)H-Index: 19
Last.Hui Wang (PKU: Peking University)H-Index: 19
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Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly cause high-mortality outbreaks in hospital settings globally. Following a patient fatality at a hospital in Beijing due to a bla KPC-2-positive CRKP infection, close monitoring was put in place over the course of 14 months to characterize all bla KPC-2-positive CRKP in circulation in the hospital. Whole genome sequences were generated for 100 isolates from bla KPC-2-positive isolates from infected patients, carriers and the hospital ...
1 CitationsSource
#1Palwasha Khan (Lond: University of London)H-Index: 8
#2Tom A Yates (UCL: University College London)H-Index: 5
Last.Alexander Pym (UCL: University College London)H-Index: 1
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Summary The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the selection of resistance-conferring mutations during inadequate antituberculosis treatment. However, HIV has a profound effect on the natural history of tuberculosis, manifesting in an increased rate of disease progression, leading to increased transmission and amplification of multidrug-resistant tuberculosis...
2 CitationsSource
#1Jon Bohlin (FHI: Norwegian Institute of Public Health)H-Index: 18
#2Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Kristian Alfsnes (FHI: Norwegian Institute of Public Health)H-Index: 4
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Background The purpose of the present study was to examine the GC content of substituted bases (sbGC) in the core genomes of 35 bacterial species. Each species, or core genome, constituted genomes from at least 10 strains. We also wanted to explore whether sbGC for each strain was associated with the corresponding species’ core genome GC content (cgGC). We present a simple mathematical model that estimates sbGC from cgGC. The model assumes only that the estimated sbGC is a function of cgGC propo...
4 CitationsSource
#2Jon Bohlin (FHI: Norwegian Institute of Public Health)H-Index: 18
Last.Ernest A. Gould (AMU: Aix-Marseille University)H-Index: 55
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Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated tha...
16 CitationsSource
#1Francois Balloux (UCL: University College London)H-Index: 56
#2Ola Brønstad Brynildsrud (FHI: Norwegian Institute of Public Health)H-Index: 12
Last.Vegard Eldholm (FHI: Norwegian Institute of Public Health)H-Index: 18
view all 8 authors...
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of environmental sources of recurrent infections (e.g., contaminated sinks) and reconstruction of transmission chains (i.e., who infected whom) could help to reduce the incidence of nosoco...
11 CitationsSource
#1Kristian AlfsnesH-Index: 4
#2Stephan A. Frye (Oslo University Hospital)H-Index: 21
Last.Ole Herman Ambur (Metropolitan University)H-Index: 9
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The spread of antibiotic resistance within and between different bacterial populations is a major health problem on a global scale. The identification of genetic transformation in genomic data from Neisseria meningitidis, the meningococcus (Mc), and other bacteria is problematic, since similar or even identical alleles may be involved. A particular challenge in naturally transformable bacteria generally is to distinguish between common ancestry and true recombined sites in sampled genome sequenc...
3 CitationsSource