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Kevin Smith
EndocrinologySkeletal muscleDiabetes mellitusMedicineBiology
360Publications
64H-index
15.4kCitations
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Publications 363
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#1James E. M. Blackwell (University of Nottingham)H-Index: 2
#2Brett Doleman (University of Nottingham)H-Index: 8
Last. Jon Lund (University of Nottingham)H-Index: 2
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To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks. A randomised control trial of consecutive patients aged (>65 years) scheduled for major urological surgery in a large secondary referral centre in a UK hospital. The primary outcome is change in anaerobic threshold (VO2AT) following HIIT vs. standard care. Forty patients were recruited (mean age 72 years, male ...
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#1Hannah CrosslandH-Index: 2
#2Kenneth G. C. SmithH-Index: 66
Last. Daniel J. WilkinsonH-Index: 2
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Abstract Background/aims Methodological challenges have been associated with the dynamic measurement of muscle protein breakdown (MPB), as have the measurement of both muscle protein synthesis (MPS) and MPB within the same experiment. Our aim was to use the transmethylation properties of methionine as proof-of-concept to measure rates of MPB via its methylation of histidine within skeletal muscle myofibrillar proteins, whilst simultaneously utilising methionine incorporation into bound protein t...
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#1Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 89
#2Helene Benveniste (Yale University)H-Index: 8
Last. Bradley J. MacIntosh (U of T: University of Toronto)H-Index: 25
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Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to prominence recently owing to advances in knowledge of their roles in clearance of interstitial fluid and waste from the brain, particularly during sleep, and in the pathogenesis of small vessel disease, Alzheimer disease and other neurodegenerative and infl...
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#1Sophie Joanisse (University of Birmingham)H-Index: 11
#2Stephen P. Ashcroft (University of Birmingham)H-Index: 3
Last. Andrew Philp (UNSW: University of New South Wales)H-Index: 28
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#2Olga Chesnokov (FAU: Florida Atlantic University)H-Index: 3
Last. Andrew V. Oleinikov (FAU: Florida Atlantic University)H-Index: 4
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Tandem Oligonucleotide Repeat Cascade Amplification (TORCA) based on signal rather than target amplification under isothermal conditions was developed for nucleic acid assays. The initial signal was generated by hybridization of single stranded DNA targets to immobilized recognition probes followed by hybrid cleavage with specific restriction endonuclease (REase), and release of trigger oligonucleotides (Tr1). The signal amplification chamber contained two bead types carrying single-stranded amp...
1 CitationsSource
#1U.S.U. Din (University of Nottingham)H-Index: 1
#2Matthew S. Brook (University of Nottingham)H-Index: 7
Last. Kevin Smith (University of Nottingham)H-Index: 64
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Summary Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that β-hydroxy-β-methyl-butyrate (HMB) supplementation during RET improves lean body mass in younger humans, and that we have shown that HMB acutely stimulates muscle protein synthesis (MPS) and inhibits breakdown; we hypothesized that chronic supplementation of HM...
1 CitationsSource
#1Haitham Abdulla (University of Nottingham)H-Index: 3
#2Joseph J. Bass (University of Nottingham)H-Index: 3
Last. Philip J. Atherton (University of Nottingham)H-Index: 43
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Background The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.
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#1Nima Gharahdaghi (University of Nottingham)H-Index: 1
#2Supreeth Rudrappa (University of Nottingham)H-Index: 2
Last. Philip J. Atherton (University of Nottingham)H-Index: 43
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Background The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia), and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RET). Nonetheless, the efficacy and physiological and molecular impacts of T therapy adjuvant to short‐term RET remain poorly defined.
1 CitationsSource
#1Matthew S. Brook (NIHR: National Institute for Health Research)H-Index: 7
#2Daniel J. Wilkinson (NIHR: National Institute for Health Research)H-Index: 19
Last. Philip J. Atherton (NIHR: National Institute for Health Research)H-Index: 43
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AbstractSkeletal muscle has indispensable roles in regulating whole body health (e.g. glycemic control, energy consumption) and, in being central in locomotion, is crucial in maintaining quality-of-life. Therefore, understanding the regulation of muscle mass is of significant importance. Resistance exercise training (RET) combined with supportive nutrition is an effective strategy to achieve muscle hypertrophy by driving chronic elevations in muscle protein synthesis (MPS). The regulation of mus...
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#1Robert W. DaviesH-Index: 2
#2Joseph J. BassH-Index: 3
Last. Philip M. JakemanH-Index: 23
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The aim of this study was to test the effects of two disparate isonitrogenous, isocaloric pre-exercise feeds on deuterium-oxide (D2O) derived measures of myofibrillar protein synthesis (myoPS) in humans. Methods: In a double-blind parallel group design, 22 resistance-trained men aged 18 to 35 years ingested a meal (6 kcal·kg−1, 0.8 g·kg−1 carbohydrate, 0.2 g·kg−1 fat) with 0.33 g·kg−1 nonessential amino acids blend (NEAA) or whey protein (WHEY), prior to resistance exercise (70% 1RM back-squats,...
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