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Albert Giralt
University of Barcelona
57Publications
22H-index
1,555Citations
Publications 57
Newest
Published on Jan 15, 2019in Translational Psychiatry 5.18
Enrica Montalban1
Estimated H-index: 1
(French Institute of Health and Medical Research),
Omar Al-Massadi + 6 AuthorsAlbert Giralt22
Estimated H-index: 22
Major depressive disorder (MDD) is a common disorder with a variety of symptoms including mood alterations, anhedonia, sleep and appetite disorders, and cognitive disturbances. Stressful life events are among the strongest risk factors for developing MDD. At the cellular level, chronic stress results in the modification of dendritic spine morphology and density. Here, we study the role of Pyk2 in the development of depressive-like symptoms induced by a model of chronic unpredictable mild stress ...
Published on Mar 1, 2019in Biological Psychiatry 11.50
Verónica Brito6
Estimated H-index: 6
(University of Barcelona),
Albert Giralt22
Estimated H-index: 22
(University of Barcelona)
+ 7 AuthorsSilvia Ginés23
Estimated H-index: 23
(University of Barcelona)
Abstract Background Depression is the most common psychiatric condition in Huntington’s disease (HD), with rates more than twice those found in the general population. At the present time, there is no established molecular evidence to use as a basis for depression treatment in HD. Indeed, in some patients, classic antidepressant drugs exacerbate chorea or anxiety. Cyclin-dependent kinase 5 (Cdk5) has been involved in processes associated with anxiety and depression. This study evaluated the invo...
Published on Feb 1, 2019in Molecular Neurobiology 4.59
Nuria Suelves4
Estimated H-index: 4
(University of Barcelona),
Andrés Miguez3
Estimated H-index: 3
(University of Barcelona)
+ 7 AuthorsVerónica Brito6
Estimated H-index: 6
(University of Barcelona)
Deficits in striatal brain-derived neurotrophic factor (BDNF) delivery and/or BDNF/tropomyosin receptor kinase B (TrkB) signaling may contribute to neurotrophic support reduction and selective early degeneration of striatal medium spiny neurons in Huntington’s disease (HD). Furthermore, we and others have demonstrated that TrkB/p75NTR imbalance in vitro increases the vulnerability of striatal neurons to excitotoxic insults and induces corticostriatal synaptic alterations. We have now expanded th...
Published on Jan 30, 2019in The Journal of Neuroscience 6.07
Benoit de Pins2
Estimated H-index: 2
(French Institute of Health and Medical Research),
Carmen Cifuentes-Diaz19
Estimated H-index: 19
(French Institute of Health and Medical Research)
+ 10 AuthorsJordi Alberch46
Estimated H-index: 46
(University of Barcelona)
It has been well documented that neurotrophins, including brain-derived neurotrophic factor (BDNF), are severely affected in Alzheimer9s disease (AD) but their administration faces a myriad of technical challenges. Here we took advantage of the early astrogliosis observed in an amyloid mouse model of AD (5xFAD) and used it as an internal sensor to administer BDNF conditionally and locally. We first demonstrate the relevance of BDNF release from astrocytes by evaluating the effects of co-culturin...
Published on Sep 1, 2018in Experimental Neurology 4.56
Albert Giralt22
Estimated H-index: 22
,
Benoit de Pins2
Estimated H-index: 2
(French Institute of Health and Medical Research)
+ 8 AuthorsJacques Hugon28
Estimated H-index: 28
(French Institute of Health and Medical Research)
Abstract Pyk2 is a Ca 2+ -activated non-receptor tyrosine kinase enriched in forebrain neurons and involved in synaptic regulation. Human genetic studies associated PTK2B , the gene coding Pyk2, with risk for Alzheimer's disease (AD). We previously showed that Pyk2 is important for hippocampal function, plasticity, and spine structure. However, its potential role in AD is unknown. To address this question we used human brain samples and 5XFAD mice, an amyloid mouse model of AD expressing mutated...
Published on Jul 1, 2018in Alzheimers & Dementia 14.42
Marion Tible4
Estimated H-index: 4
,
François Mouton-Liger13
Estimated H-index: 13
+ 7 AuthorsJacques Hugon28
Estimated H-index: 28
Published on May 1, 2018in Molecular metabolism 6.18
Albert Giralt22
Estimated H-index: 22
(UNIL: University of Lausanne),
Pierre-Damien Denechaud9
Estimated H-index: 9
(UNIL: University of Lausanne)
+ 6 AuthorsLluis Fajas30
Estimated H-index: 30
(UNIL: University of Lausanne)
Abstract Objective Aberrant hepatic glucose production contributes to the development of hyperglycemia and is a hallmark of type 2 diabetes. In a recent study, we showed that the transcription factor E2F1, a component of the cell cycle machinery, contributes to hepatic steatosis through the transcriptional regulation of key lipogenic enzymes. Here, we investigate if E2F1 contributes to hyperglycemia by regulating hepatic gluconeogenesis. Methods We use different genetic models to investigate if ...
Published on Jan 1, 2018in Molecular and Cellular Neuroscience 2.85
Silvia Cases2
Estimated H-index: 2
(University of Barcelona),
Ana Saavedra13
Estimated H-index: 13
(University of Barcelona)
+ 3 AuthorsEsther Pérez-Navarro30
Estimated H-index: 30
(University of Barcelona)
Abstract Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes during postnatal development and aging. Here, we studied STEP ontogeny in mouse brain and changes in STEP with age with emphasis on the possible regulation by BDNF. We found that STEP expression increased during the first weeks of life, reaching adult levels by 2–3 weeks of age in the striatum and cortex, and by pos...
Published on Dec 21, 2017in Frontiers in Endocrinology 3.63
Albert Giralt22
Estimated H-index: 22
(UNIL: University of Lausanne),
Lluis Fajas30
Estimated H-index: 30
(UNIL: University of Lausanne)
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