Albert Giralt
University of Barcelona
Publications 58
#1Albert GiraltH-Index: 23
#2Verónica BritoH-Index: 6
Last.Josep M. CanalsH-Index: 36
view all 19 authors...
Abstract Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in devel...
#1Enrica Montalban (French Institute of Health and Medical Research)H-Index: 2
#2Omar Al-MassadiH-Index: 1
Last.Albert GiraltH-Index: 23
view all 9 authors...
Major depressive disorder (MDD) is a common disorder with a variety of symptoms including mood alterations, anhedonia, sleep and appetite disorders, and cognitive disturbances. Stressful life events are among the strongest risk factors for developing MDD. At the cellular level, chronic stress results in the modification of dendritic spine morphology and density. Here, we study the role of Pyk2 in the development of depressive-like symptoms induced by a model of chronic unpredictable mild stress ...
2 CitationsSource
#1Benoit de Pins (French Institute of Health and Medical Research)H-Index: 3
#2Enrica Montalban (French Institute of Health and Medical Research)H-Index: 2
Last.Jean-Antoine Girault (French Institute of Health and Medical Research)H-Index: 64
view all 5 authors...
The striatum is a critical brain region for locomotor response to cocaine. Although the D1 receptor-expressing neurons are centrally involved in mediating the locomotor effects of cocaine, the molecular pathways controlling this response are not fully understood. Here we studied the role of Pyk2, a non-receptor calcium-dependent protein-tyrosine kinase, in striatum-related functions. We discovered that cocaine injection increases Pyk2 phosphorylation in the striatum of mice in vivo. Pyk2-deficie...
#1Verónica Brito (University of Barcelona)H-Index: 6
#2Albert Giralt (University of Barcelona)H-Index: 23
Last.Silvia Ginés (University of Barcelona)H-Index: 23
view all 10 authors...
Abstract Background Depression is the most common psychiatric condition in Huntington’s disease (HD), with rates more than twice those found in the general population. At the present time, there is no established molecular evidence to use as a basis for depression treatment in HD. Indeed, in some patients, classic antidepressant drugs exacerbate chorea or anxiety. Cyclin-dependent kinase 5 (Cdk5) has been involved in processes associated with anxiety and depression. This study evaluated the invo...
#1Marion Tible (French Institute of Health and Medical Research)H-Index: 5
#2François Mouton-Liger (French Institute of Health and Medical Research)H-Index: 11
Last.Jacques Hugon (French Institute of Health and Medical Research)H-Index: 28
view all 12 authors...
#1Nuria Suelves (University of Barcelona)H-Index: 4
#2Andrés Miguez (University of Barcelona)H-Index: 3
Last.Verónica Brito (University of Barcelona)H-Index: 6
view all 10 authors...
Deficits in striatal brain-derived neurotrophic factor (BDNF) delivery and/or BDNF/tropomyosin receptor kinase B (TrkB) signaling may contribute to neurotrophic support reduction and selective early degeneration of striatal medium spiny neurons in Huntington’s disease (HD). Furthermore, we and others have demonstrated that TrkB/p75NTR imbalance in vitro increases the vulnerability of striatal neurons to excitotoxic insults and induces corticostriatal synaptic alterations. We have now expanded th...
2 CitationsSource
#1Benoit de Pins (French Institute of Health and Medical Research)H-Index: 3
#2Carmen Cifuentes-Diaz (French Institute of Health and Medical Research)H-Index: 21
Last.Albert Giralt (University of Barcelona)H-Index: 23
view all 13 authors...
It has been well documented that neurotrophins, including brain-derived neurotrophic factor (BDNF), are severely affected in Alzheimer9s disease (AD) but their administration faces a myriad of technical challenges. Here we took advantage of the early astrogliosis observed in an amyloid mouse model of AD (5xFAD) and used it as an internal sensor to administer BDNF conditionally and locally. We first demonstrate the relevance of BDNF release from astrocytes by evaluating the effects of co-culturin...
3 CitationsSource
#1Albert GiraltH-Index: 23
#2Benoit de Pins (French Institute of Health and Medical Research)H-Index: 3
Last.Jean-Antoine Girault (French Institute of Health and Medical Research)H-Index: 64
view all 11 authors...
Abstract Pyk2 is a Ca2+-activated non-receptor tyrosine kinase enriched in forebrain neurons and involved in synaptic regulation. Human genetic studies associated PTK2B, the gene coding Pyk2, with risk for Alzheimer's disease (AD). We previously showed that Pyk2 is important for hippocampal function, plasticity, and spine structure. However, its potential role in AD is unknown. To address this question we used human brain samples and 5XFAD mice, an amyloid mouse model of AD expressing mutated hu...
7 CitationsSource
#1Marion TibleH-Index: 5
Last.Jacques HugonH-Index: 28
view all 10 authors...
#1Silvia Cases (University of Barcelona)H-Index: 2
#2Ana Saavedra (University of Barcelona)H-Index: 13
Last.Esther Pérez-Navarro (University of Barcelona)H-Index: 31
view all 6 authors...
Abstract Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes during postnatal development and aging. Here, we studied STEP ontogeny in mouse brain and changes in STEP with age with emphasis on the possible regulation by BDNF. We found that STEP expression increased during the first weeks of life, reaching adult levels by 2–3 weeks of age in the striatum and cortex, and by pos...
2 CitationsSource