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Le Wang
National University of Singapore
28Publications
10H-index
364Citations
Publications 28
Newest
#1Yubang Shen (Shanghai Ocean University)
#2Le Wang (NUS: National University of Singapore)H-Index: 10
Last.Jiale Li (Shanghai Ocean University)H-Index: 21
view all 6 authors...
Background Genetic diversity within a species reflects population evolution, ecology, and ability to adapt. Genome-wide population surveys of both natural and introduced populations provide insights into genetic diversity, the evolutionary processes and the genetic basis underlying local adaptation. Grass carp is the most important freshwater foodfish species for food and water weed control. However, there is as yet no overall picture on genetic variations and population structure of this specie...
#1Le Wang (NUS: National University of Singapore)H-Index: 10
#2Elaine Chua (NUS: National University of Singapore)H-Index: 4
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 8 authors...
Asian seabass is an important food fish species. While improving growth, increasing the nutritional value is important, omega-3 fatty acids are indispensable to human health. Identifying and validating DNA markers associated with traits is the first step towards marker-assisted selection (MAS). We quantified 13 different fatty acids and three growth traits in 213 F2 Asian seabass from a family at the age 270 days post hatch, and screened QTL for these traits. The content of total fatty acids in ...
#1Le Wang (NUS: National University of Singapore)H-Index: 10
view all 6 authors...
High-density genetic maps are essential for mapping QTL, improving genome assembly, comparative genomics, and studying sex chromosome evolution. The northern snakehead (Channa argus) is an economically important foodfish species with significant sexual dimorphism, where the males grow much faster and bigger than the females. However, to date, the sex determination pattern is still not clear, limiting identification of sex chromosomes, even sex determination genes and development of monosex popul...
#1Bin Bai (NUS: National University of Singapore)H-Index: 5
#2Le Wang (NUS: National University of Singapore)H-Index: 10
Last.Nam-Hai Chua (Rockefeller University)H-Index: 12
view all 10 authors...
Oil palm (Elaeis guineensis Jacq.) is the leading oil-producing crops and the most important edible oil resource worldwide. DNA markers and genetic linkage maps are essential resources for marker-assisted selection to accelerate genetic improvement. We conducted RAD-seq on an Illumina NextSeq500 to discover genome-wide SNPs, and used the SNPs to construct a linkage map for an oil palm (Tenera) population derived from a cross between a Deli Dura and an AVROS Pisifera. The RAD-seq produced 1,076 m...
#1Bin Bai (NUS: National University of Singapore)H-Index: 5
#2Yingjun Zhang (NUS: National University of Singapore)H-Index: 2
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 10 authors...
Leaf area is an important parameter in oil palm breeding as it is positively correlated with oil yield. However, measurement of leaf area is tedious and also destructive. In the present study, a breeding population with 145 palms derived from a cross between Deli Dura and Avros Pisifera was used to construct a high-density linkage map and identify quantitative trait loci (QTL) for leaf area in oil palm. Using genotyping by sequencing, a linkage map containing 2413 SNPs was constructed. The total...
#1Grace Lin (NUS: National University of Singapore)H-Index: 17
#2Le Wang (NUS: National University of Singapore)H-Index: 10
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 6 authors...
Tilapia is one of most important foodfish species. The low omega-3 to omega-6 fatty acid ratio in freshwater tilapia meat is disadvantageous for human health. Increasing omega-3 content is an important task in breeding to increase the nutritional value of tilapia. However, conventional breeding to increase omega-3 content is difficult and slow. To accelerate the increase of omega-3 through marker-assisted selection (MAS), we conducted QTL mapping for fatty acid contents and profiles in a F2 fami...
#1Le Wang (NUS: National University of Singapore)H-Index: 10
#2Bin Bai (NUS: National University of Singapore)H-Index: 5
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 8 authors...
Background A high-density genetic map is essential for de novo genome assembly, fine mapping QTL for important complex traits, comparative genomic studies and understanding the mechanisms of genome evolution. Although a number of genomic resources are available in Asian seabass (Lates calcarifer), a high-density linkage map is still lacking. To facilitate QTL mapping for marker-assisted selection and genome assembly, and to understand the genome-wide recombination rates, we constructed high dens...
#1Bin Bai (NUS: National University of Singapore)H-Index: 5
#2Le Wang (NUS: National University of Singapore)H-Index: 10
Last.Antonius Suwanto (IPB: Bogor Agricultural University)H-Index: 13
view all 10 authors...
Background Oil palm (Elaeis guineensis, Jacq.) is the most important source of edible oil. The improvement of oil yield is currently slow in conventional breeding programs due to long generation intervals. Marker-assisted selection (MAS) has the potential to accelerate genetic improvement. To identify DNA markers associated with oil content traits for MAS, we performed quantitative trait loci (QTL) mapping using genotyping by sequencing (GBS) in a breeding population derived from a cross between...
#1Le Wang (NUS: National University of Singapore)H-Index: 10
#2Bin Bai (NUS: National University of Singapore)H-Index: 5
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 8 authors...
Identifying quantitative trait loci (QTL) for viral disease resistance is of particular importance in selective breeding programs of fish species. Genetic markers linked to QTL can be useful in marker-assisted selection (MAS) for elites resistant to specific pathogens. Here, we conducted a genome scan for QTL associated with Singapore grouper iridovirus (SGIV) resistance in an Asian seabass (Lates calcarifer) family, using a high-density linkage map generated with genotyping-by-sequencing. One g...
#1Le Wang (NUS: National University of Singapore)H-Index: 10
#2Peng Liu (NUS: National University of Singapore)H-Index: 14
Last.Gen Hua Yue (NUS: National University of Singapore)H-Index: 33
view all 7 authors...
Viral nervous necrosis disease (VNN), caused by nervous necrosis virus (NNV), is one major threat to mariculture. Identifying loci and understanding the mechanisms associated with resistance to VNN are important in selective breeding programs. We performed a genome-wide association study (GWAS) using genotyping-by-sequencing (GBS) to study the genomic architecture of resistance to NNV infection in Asian seabass. We genotyped 986 individuals from 43 families produced by 15 founders with 44498 bi-...
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