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Kim P. C. Kuypers
Maastricht University
85Publications
21H-index
1,186Citations
Publications 85
Newest
#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Natasha L. Mason (UM: Maastricht University)H-Index: 3
Last.Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 4 authors...
Background. There is a growing interest in the use of psychedelic substances for health related purposes, including symptom relief for disorders like anxiety, depression, and pain. Although the focus of recent clinical trials has been on high doses of these substances, anecdotal evidence suggests that low (micro) doses are also effective, and may be more suitable for certain conditions. Nonetheless, empirical evidence regarding the efficacy of microdosing with psychedelics for symptomatic relief...
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#1Hannes Kettner (UM: Maastricht University)
#2Natasha L. Mason (UM: Maastricht University)H-Index: 3
Last.Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
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Novel psychoactive substances (NPS) are compounds designed to mimic the effects of existing recreational drugs (classical psychoactive substances [CPS]), while eluding established legal frameworks....
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#1M. V. Uthaug (UM: Maastricht University)H-Index: 2
#2R. LancelottaH-Index: 1
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
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Background 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.
2 CitationsSource
#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2Livia Ng (UCL: University College London)H-Index: 1
Last.David J. Nutt (Imperial College London)H-Index: 86
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Background:In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cog...
1 CitationsSource
#1Stefan W. Toennes (Goethe University Frankfurt)H-Index: 20
#2David Schneider (Goethe University Frankfurt)
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
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INTRODUCTION: Each year, synthetic drugs are occurring in high numbers in the illicit drug market. But data on their pharmacology and toxicology are scarcely available. Therefore, a controlled study was performed to evaluate pharmacokinetic parameters of 4-fluoroamphetamine (4FA) in humans and to compare it with its effects. METHODS: Twelve subjects ingested 100 mg and 5 subjects also received 150 mg 4-FA in a bitter lemon drink. Blood and oral fluid samples were taken during the following 12 ho...
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#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Natasha L. Mason (UM: Maastricht University)H-Index: 3
Last.Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 4 authors...
3 CitationsSource
#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Laura Steenbergen (LEI: Leiden University)H-Index: 10
Last.Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 7 authors...
Abstract Anecdotal evidence suggests that cocaine use will help overcome creative ‘blocks’ by enhancing flexible thinking. Given that cocaine is likely to enhance dopamine (DA) levels, which in turn are positively associated with divergent thinking (DT); is a possibility that is tested in the present study. Furthermore, the impact of cocaine is tested on convergent thinking (CT), another aspect of creative thinking, which has been reported to be impaired with high DA levels. It was hypothesized ...
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#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
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ABSTRACTThe phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA. Since 4-FA users report their subjective experience ranges between the effects induced by amphetamine and MDMA, and it is known that both substances can produce an altered state of consciousness, this study tests whether 4-FA induces a psychedelic state. A placebo-controlled two-way crossover study in 12 healthy poly-drug users was c...
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#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
Abstract Psychedelic substances have regained interest as therapeutic agents in the treatment of stress-related disorders. The effects seem to be of persisting nature even after a single dose. Also in lower than ‘regular’ recreational doses, so-called micro-doses, without the typical effects on consciousness, users report beneficial effects on cognitive processes and well-being. The exact neurobiological mechanism underlying these persisting effects is not clear. While previous research has main...
1 CitationsSource
#1Natasha L. Mason (UM: Maastricht University)H-Index: 3
#2Elisabeth MischlerH-Index: 1
Last.Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 4 authors...
ABSTRACTCreative thinking and empathy are crucial for everyday interactions and subjective well-being. This is emphasized by studies showing a reduction in these skills in populations where social interaction and subjective well-being are significantly compromised (e.g., depression). Anecdotal reports and recent studies suggest that a single administration of psilocybin can enhance such processes and could therefore be a potential treatment. However, it has yet to be assessed whether effects out...
2 CitationsSource
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