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Jacob S. Bowers
Medical University of South Carolina
Cytotoxic T cellCD8ImmunologyT cellBiology
14Publications
8H-index
186Citations
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Publications 17
Newest
#1Michael B. Ware (Emory University)H-Index: 1
#2Christopher McQuinn (OSU: Ohio State University)H-Index: 3
Last. Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
view all 17 authors...
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is exceptionally resistant to immune checkpoint inhibition (ICI). We previously reported that elevated systemic interleukin-6 (IL-6) and increased numbers of T cells positive for circulating cytotoxic T-lymphocyte-associated protein 4 (CTLA 4) correlate with worse overall survival in patients with PDAC. We postulated that combined blockade of IL-6 and CTLA-4 would significantly enhance anti-tumor immune responses to PDAC. Dual blockade of IL-6 an...
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#1Michelle H. Nelson (MUSC: Medical University of South Carolina)H-Index: 11
#2Hannah M. Knochelmann (MUSC: Medical University of South Carolina)H-Index: 3
Last. Chrystal M. Paulos (MUSC: Medical University of South Carolina)H-Index: 28
view all 15 authors...
How naturally arising human CD4+ T helper subsets impact tumor immunity is unknown. We reported that human CD4+CD26high T cells elicit potent immunity against solid tumor malignancies. As CD26high T cells secrete type-17 cytokines and have been categorized as Th17 cells, we posited these helper populations would possess similar molecular properties. Herein, we reveal that CD26high T cells are epigenetically and transcriptionally distinct from Th17 cells. Of clinical significance, CD26high T cell...
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#1Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
#2Stefanie R. Bailey (Harvard University)H-Index: 1
Last. E. Ramsay Camp (MUSC: Medical University of South Carolina)H-Index: 10
view all 5 authors...
Pancreatic adenocarcinoma (PDAC) remains a formidable disease that needs improved therapeutic strategies. Even though immunotherapy has revolutionized treatment for various solid tumor types, it remains largely ineffective in treating individuals with PDAC. This review describes how the application of genome-wide analysis is revitalizing the field of PDAC immunotherapy. Major themes include new insights into the body’s immune response to the cancer, and key immunosuppressive elements that blunt ...
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#1Stefanie R. Bailey (MUSC: Medical University of South Carolina)H-Index: 8
#2Michelle H. NelsonH-Index: 11
Last. Chrystal M. Paulos (MUSC: Medical University of South Carolina)H-Index: 28
view all 12 authors...
CD8+ T lymphocytes mediate potent immune responses against tumor, but the role of human CD4+ T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26neg T cells possess a regulatory phenotype, CD26int T cells are mainly naive and CD26high T cells appear terminally differentiated and exhausted. Paradoxically, CD26high T cells persi...
15 CitationsSource
#1Matthew J. Scheffel (MUSC: Medical University of South Carolina)H-Index: 5
#2Kristi L. Helke (MUSC: Medical University of South Carolina)H-Index: 13
Last. Christina Voelkel-Johnson (MUSC: Medical University of South Carolina)H-Index: 24
view all 8 authors...
Sphingolipids regulate critical cellular processes including inflammation. Ceramide, which serves a central role in sphingolipid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate specificity. CerS6 preferentially generates C16-ceramide and its mRNA is highly expressed in immune tissues. In this study we analyzed how deficiency of CerS6 impacts on the development of colitis using an adoptive transfer model. Adoptive transfer of CerS6-deficient splenocytes, which h...
8 CitationsSource
#1Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
#2Kinga MajchrzakH-Index: 12
Last. Chrystal M. Paulos (MUSC: Medical University of South Carolina)H-Index: 28
view all 10 authors...
Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells (Tregs). Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 therapy. Herein, we demonstrate a direct effect of p110δ inactivation via CAL-101 on murine and human CD8+ T cells that promotes a strong undifferentiated phenotype (elevated...
8 CitationsSource
#1Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
#2Kinga Majchrzak (Warsaw University of Life Sciences)H-Index: 12
Last. Chrystal M. Paulos (MUSC: Medical University of South Carolina)H-Index: 28
view all 10 authors...
Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells (Tregs). Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 therapy. Herein, we demonstrate a direct effect of p110δ inactivation via CAL-101 on murine and human CD8+ T cells that promotes a strong undifferentiated memory phenotype (e...
1 CitationsSource
#1Daniel J. Neitzke (MUSC: Medical University of South Carolina)H-Index: 3
#2Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
Last. Mark P. Rubinstein (MUSC: Medical University of South Carolina)H-Index: 22
view all 10 authors...
Adoptive cellular therapy (ACT) with the Th17 subset of CD4+ T cells can cure established melanoma in preclinical models and holds promise for treating human cancer. However, little is known about the growth factors necessary for optimal engraftment and anti-tumor activity of Th17 cells. Due to the central role of IL-2 receptor gamma chain (IL2Rγ-chain) cytokines (IL-2, IL-7, and IL-15) in the activity and persistence of many T cell subsets after adoptive transfer, we hypothesized that these cyt...
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#1Kinga MajchrzakH-Index: 12
#2Michelle H. NelsonH-Index: 11
Last. Chrystal M. PaulosH-Index: 28
view all 12 authors...
16 CitationsSource
#1Brian T. Malik (Dartmouth College)H-Index: 3
#2Katelyn T. Byrne (UPenn: University of Pennsylvania)H-Index: 14
Last. Mary Jo Turk (Dartmouth College)H-Index: 23
view all 12 authors...
Tissue-resident memory T (T RM ) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen–specific T RM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. These cells expre...
63 CitationsSource
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