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Alzira Melo
Instituto de Medicina Molecular
Quality of lifePhysical therapyCambridge Pulmonary Hypertension Outcome ReviewPulmonary hypertensionMedicine
9Publications
2H-index
11Citations
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Publications 9
Newest
#1Maria Conceição Pereira Santos (IMM: Instituto de Medicina Molecular)H-Index: 2
#2Ana Serra-Caetano (IMM: Instituto de Medicina Molecular)H-Index: 6
Last. Ana E. Sousa (IMM: Instituto de Medicina Molecular)H-Index: 29
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#1Mário Santos (University of Porto)H-Index: 13
#2Ana P. GomesH-Index: 21
Last. Abílio ReisH-Index: 4
view all 10 authors...
Abstract Objectives This study aims to assess the long-term survival of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients followed in a Portuguese pulmonary hypertension (PH) referral center. Methods We studied PAH and CTEPH patients diagnosed between January 2005 and December 2016. Cumulative survival was estimated using the Kaplan-Meier method. Survival trends were compared over two periods (2005-2010 vs. 2011-2016). Results Of the 142 stu...
Source
#1Ana P. GomesH-Index: 21
#2Célia F. CruzH-Index: 5
Last. Abílio ReisH-Index: 4
view all 10 authors...
Abstract Background Pulmonary hypertension (PH) is a heterogeneous, debilitating condition with highly relevant impact on functional capacity, quality of life, and life-expectancy. Objectives This study aims to provide long-term data on the Portuguese PH population, by characterising the clinical presentation, evolution, and outcomes of PH patients in a specialised referral centre. Methods Retrospective analysis of a cohort of 101 patients with pre-capillary PH (pcPH) referenced to an expert ter...
1 CitationsSource
#1Abílio ReisH-Index: 4
#2Mário SantosH-Index: 13
Last. Luis Almeida (University of Porto)H-Index: 38
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Background. Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates. Materials and Methods. A cross-sectional, observational study of patients with documented PAH and other forms of pcPH. Patients completed two patient-reported outc...
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#1Abílio ReisH-Index: 4
#2James TwissH-Index: 12
Last. Luis AlmeidaH-Index: 38
view all 9 authors...
Source
#1Abílio ReisH-Index: 4
#2James TwissH-Index: 12
Last. Luis Almeida (University of Aveiro)H-Index: 38
view all 9 authors...
Background Patients with pulmonary arterial hypertension (PAH) and other forms of precapillary pulmonary hypertension (PH) have impaired quality of life (QoL). The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is a PH-specific patient-reported outcome measure that assesses symptoms, activity limitations and QoL. It was originally developed in UK-English. The main objective of this study was to create an adaptation of the CAMPHOR suitable for a Portuguese-speaking population.
4 CitationsSource
#1Íris Caramalho (IMM: Instituto de Medicina Molecular)H-Index: 15
#2Alzira Melo (IMM: Instituto de Medicina Molecular)H-Index: 2
Last. Ana E. Sousa (IMM: Instituto de Medicina Molecular)H-Index: 29
view all 7 authors...
Venom-specific immunotherapy (VIT) is well recognized by its efficacy, and compelling evidence implicates regulatory T cells (Tregs) in the underlying tolerogenic mechanisms. Additionally, hymenoptera venom has for a long time been claimed to modulate immunity. Here, we investigated the putative role of bee venom (Bv) in human FOXP3-expressing Treg homeostasis and differentiation, irrespective of the donors' allergic status. We found that Bv significantly enhanced the differentiation of FOXP3-ex...
5 CitationsSource
#1Abílio ReisH-Index: 4
#2Margarida Vicente (University of Aveiro)H-Index: 1
Last. Luis Almeida (University of Aveiro)H-Index: 38
view all 6 authors...
Background and objectives: Pulmonary Arterial Hypertension (PAH) is a chronic and disabling illness that impairs patient9s functionality and Quality of Life (QoL). Multiple biomarkers have been used to evaluate functionality and several QoL questionnaires to assess QoL. However, there is limited knowledge about their correlations. Methods: Study participants completed PAH-specific (CAMPHOR) and general (NHP) QoL questionnaires as part of a programmed evaluation and patients9 demographic, clinica...
Abstract Rationale Basophil activation by flow cytometry (BAFC) allows the study of type I hypersensitivity. In this study we evaluated the effect of specific immunotherapy (SIT) in patients with allergic rhinitis on BAFC. Methods 3 groups of patients with allergic rhinitis confirmed by clinically history, skin tests and specific IgE (sIgE). Group I: 12 patients (15-55 years old), 5 females and 7 males with SIT, performed with a modified extract of Dermatophagoides pteronyssinus, Depigoid ®. Gro...
1 CitationsSource
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