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Michel Perron
Université du Québec à Chicoutimi
131Publications
31H-index
2,574Citations
Publications 131
Newest
Published on Sep 11, 2018in International Journal of Obesity 4.51
Catriona Syme13
Estimated H-index: 13
(U of T: University of Toronto),
Stephanie Pelletier (U of T: University of Toronto)+ 14 AuthorsDaniel Gaudet56
Estimated H-index: 56
(UdeM: Université de Montréal)
Life-long maintenance of brain health is important for the prevention of cognitive impairment in older age. Low-grade peripheral inflammation associated with excess visceral fat (VF) may influence brain structure and function. Here we examined (i) if this type of inflammation is associated with altered white-matter (WM) microstructure and lower cognitive functioning in adolescents, and (ii) if recently identified circulating glycerophosphocholines (GPCs) can index this type of inflammation and a...
Published on Sep 1, 2018in Cerebral Cortex 5.44
Jean Shin6
Estimated H-index: 6
(U of T: University of Toronto),
Leon French14
Estimated H-index: 14
(U of T: University of Toronto)
+ 7 AuthorsTomáš Paus82
Estimated H-index: 82
Published on Apr 1, 2018in Cerebral Cortex 5.44
Angelita Pui-Yee Wong3
Estimated H-index: 3
(U of T: University of Toronto),
Leon French14
Estimated H-index: 14
(U of T: University of Toronto)
+ 6 AuthorsTomáš Paus82
Estimated H-index: 82
Abstract Age-related decreases in cortical thickness observed during adolescence may be related to fluctuations in sex and stress hormones. We examine this possibility by relating inter-regional variations in age-related cortical thinning (data from the Saguenay Youth Study) to inter-regional variations in expression levels of relevant genes (data from the Allen Human Brain Atlas); we focus on genes coding for glucocorticoid receptor (NR3C1), androgen receptor (AR), progesterone receptor (PGR), ...
Published on Jan 1, 2018
M. Gaudreault4
Estimated H-index: 4
,
Isabelle Morin + 2 AuthorsSuzanne Veillette
La pregnance des disparites spatiales de perseverance et de reussite scolaires laisse presager l’influence de reels facteurs territoriaux sur les parcours scolaires des jeunes. Pour apprehender de tels facteurs, des analyses multivariees ont ete menees sur 101 municipalites regionales de comte (MRC) du Quebec. En tout, 172 variables associees a cinq composantes du territoire (demographie et familles, diversite ethnoculturelle, marche de l’emploi, conditions de vie et occupation du territoire) on...
Published on Dec 1, 2017in Scientific Reports 4.01
Nadine Parker1
Estimated H-index: 1
(U of T: University of Toronto),
Angelita Pui-Yee Wong3
Estimated H-index: 3
(U of T: University of Toronto)
+ 6 AuthorsTomáš Paus82
Estimated H-index: 82
Income inequality is associated with poor health and social outcomes. Negative social comparisons and competition may involve the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in underlying some of these complex inter-relationships. Here we investigate brain maturation, indexed by age-related decreases in cortical thickness, in adolescents living in neighborhoods with differing levels of income inequality and household income. We examine whether inter-regiona...
Published on Sep 1, 2017in Hypertension 7.02
Catriona Syme13
Estimated H-index: 13
,
Jean Shin6
Estimated H-index: 6
+ 7 AuthorsZdenka Pausova41
Estimated H-index: 41
Hypertension is a leading cause of death. Sex differences in blood pressure (BP) and hypertension prevalence emerge during adolescence and remain throughout reproductive age. Sex differences in BP-underlying hemodynamics, i.e., in the relative contributions of stroke volume (SV), total peripheral resistance (TPR) and heart rate (HR) to BP, have not been investigated in these age categories in a population-based setting. We studied a cohort of 1,347 individuals, including 911 adolescents (12-18 y...
Published on Apr 1, 2017in Antiviral Research 4.13
Kirsten M. Stray13
Estimated H-index: 13
,
Yeojin Park8
Estimated H-index: 8
+ 4 AuthorsMichel Perron31
Estimated H-index: 31
HIV-infected patients treated with certain nucleoside reverse transcriptase inhibitors (NRTIs) have experienced adverse effects due to drug-related mitochondrial toxicity. Tenofovir alafenamide (TAF) is a novel prodrug of the NRTI tenofovir (TFV) with an improved safety profile compared to tenofovir disoproxil fumarate (TDF). Prior in vitro studies have demonstrated that the parent nucleotide TFV has no significant effects on mtDNA synthesis. This study investigated whether clinically relevant T...
Published on Mar 9, 2017in Journal of Medicinal Chemistry 1.51
Dustin Siegel7
Estimated H-index: 7
,
Hon Chung Hui20
Estimated H-index: 20
+ 30 AuthorsBruce S. Ross16
Estimated H-index: 16
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500 healthcare workers. A focused screening and lead optimization effort identified 4b (GS-5734) with anti-EBOV EC50 = 86 nM in macrophages as the clinical candidate. Structure activity relationships established that the 1′-CN group and C-linked nucleobase were critical for optimal anti-EBOV potency and selectivity against host polymerases. A ro...
Published on Mar 1, 2017in Scientific Reports 4.01
Michael K. Lo16
Estimated H-index: 16
,
Robert Jordan35
Estimated H-index: 35
+ 14 AuthorsMichael O. Clarke6
Estimated H-index: 6
Published on Nov 22, 2016in Circulation 23.05
Catriona Syme13
Estimated H-index: 13
,
Simon Czajkowski1
Estimated H-index: 1
+ 13 AuthorsLisa J. Strug25
Estimated H-index: 25
Background: Glycerophosphocholine (GPC) metabolites modulate atherosclerosis and thus risk for cardiovascular disease (CVD). Preclinical CVD may start during adolescence. Here, we used targeted serum lipidomics to identify a new panel of GPCs, and tested whether any of these GPCs are associated, in adolescence, with classical risk factors of CVD, namely excess visceral fat (VF), elevated blood pressure, insulin resistance, and atherogenic dyslipidemia. Methods: We studied a population-based samp...
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