Match!
Aasheesh Srivastava
Indian Institute of Science Education and Research, Bhopal
50Publications
16H-index
851Citations
Publications 51
Newest
The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands, thereby facilitating the cancer cells growth. We have investigated the largely unexplored epigenetic mechanism of PKM splicing switch in head and neck cancer (HNC) cells. Considering the reversible natur...
Source
#1Sanjay Pal (KIIT: KIIT University)H-Index: 2
#2Nihal Medatwal (Manipal University)H-Index: 2
Last.Avinash BajajH-Index: 22
view all 18 authors...
Rapid proliferation of cancer cells assisted by endothelial cell-mediated angiogenesis and acquired inflammation at the tumor microenvironment (TME) lowers the success rate of chemotherapeutic regimens. Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiprolife...
Source
#1Aasheesh Srivastava (IISc: Indian Institute of Science)H-Index: 16
#2Anand Kumar Awasthi (Indian Institutes of Science Education and Research)
Last.Reshma Ramakrishnan (Indian Institutes of Science Education and Research)
view all 4 authors...
Source
#1Sandeep Kumar (Manipal University)H-Index: 4
#2Jyoti Thakur (Indian Institute of Science Education and Research, Bhopal)H-Index: 1
Last.Avinash BajajH-Index: 22
view all 19 authors...
Inappropriate and uncontrolled use of antibiotics results in emergence of antibiotic resistance, thereby threatening the present clinical regimens to treat infectious diseases. Therefore, new antimicrobial agents that can prevent the bacteria to develop drug resistance are urgently needed. Selective disruption of bacterial membranes is the most effective strategy for combating microbial infections as accumulation of the genetic mutations cannot allow the emergence of drug resistance against thes...
1 CitationsSource
2 CitationsSource
#1Rajesh Kumar (Indian Institute of Science Education and Research, Bhopal)H-Index: 2
#2Himanshu Aggarwal (Indian Institute of Science Education and Research, Bhopal)H-Index: 1
Last.Aasheesh Srivastava (Indian Institute of Science Education and Research, Bhopal)H-Index: 16
view all 5 authors...
Source
#1Kavita Yadav (Manipal University)H-Index: 3
#2Sandeep Kumar (Manipal University)H-Index: 4
Last.Avinash BajajH-Index: 22
view all 18 authors...
The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid–peptide conjugates (CAPs), demonstrating that valine–glycine dipeptide-derived CAP 3 is the most effective antimicrobial. Molecular dynamics simulations and structural analysis revealed that a precise intramolecular network of CAP 3 is maintained in the form of evolving edges, ...
2 CitationsSource
#1Prabhu Srinivas Yavvari (IISc: Indian Institute of Science)H-Index: 5
#2Anand Kumar Awasthi (IISc: Indian Institute of Science)H-Index: 1
Last.Aasheesh Srivastava (IISc: Indian Institute of Science)H-Index: 16
view all 5 authors...
Polyelectrolytes (PELs) – polymers with charged repeat units – have emerged as a useful class of polymers for biomedical applications due to their high aqueous solubility, low aggregation propensity and the opportunity they afford for polyvalent interactions with surfaces. Biodegradability and biocompatibility of PELs are important prerequisites for their utilization in in vivo applications. PELs that can be chemically functionalized with ease prove advantageous for creating diverse biomaterials...
1 CitationsSource
#1Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
#2Priyanka VermaH-Index: 1
Last.Avinash BajajH-Index: 22
view all 10 authors...
Poor success rates and challenges associated with the current therapeutic strategies of inflammatory bowel disease (IBD) have accelerated the emergence of gene therapy as an alternative treatment option with great promise. However, oral delivery of nucleic acids (NAs) to an inflamed colon is challenged by multiple barriers presented by the gastrointestinal, extracellular and intracellular compartments. Therefore, we screened a series of polyaspartic acid-derived amphiphilic cationic polymers wit...
1 CitationsSource
#1Somnath D. Bhagat (Indian Institute of Science Education and Research, Bhopal)H-Index: 2
#2Usha Singh (Indian Institute of Science Education and Research, Bhopal)H-Index: 2
Last.Aasheesh Srivastava (Indian Institute of Science Education and Research, Bhopal)H-Index: 16
view all 4 authors...
2 CitationsSource
123456