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Bianca Ramos Pezzini
Universidade Federal de Santa Catarina
Nuclear chemistrySolubilityChemistryChromatographyDissolution
31Publications
6H-index
151Citations
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Publications 32
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Abstract A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied: Kolliphor® EL or PEG 400. The studied parameters were the concentrations of NVS (A-Kolliphor® EL, 0–40% w/w; or PEG 400, 0–31.1% w/w), coating material (B-crospovidone, 0–50.3% w/w) and carrier (C...
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Our research group has pioneered the development of liquisolid pellets as a new drug delivery system targeting at the improvement of the dissolution rates of poorly water-soluble drugs, combining the technological and biopharmaceutical advantages of both multiparticulate and liquisolid systems. Recently, Lam and collaborators claimed the invention of “liqui-pellets” as “the emerging next-generation oral dosage form which stems from liquisolid concept in combination with pelletization technology”...
1 CitationsSource
#1Giovana Carolina Bazzo (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
#2Dina Mahmoud Mostafa (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
view all 5 authors...
Abstract Efavirenz (EFZ) and tenofovir disoproxil fumarate (TDF) can be used simultaneously in the treatment of human immunodeficiency virus type1 infection. In this work the impact of TDF, a hydrophilic drug, on the solubility and dissolution rate of EFZ, a poorly water-soluble drug, was evaluated. EFZ/TDF binary mixtures in different molar ratios were prepared. Differential scanning calorimetry (DSC) results indicate the formation of a eutectic mixture, the molar ratio of 65/35 being the eutec...
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#1Brenda De Espíndola (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2André O'Reilly Beringhs (UConn: University of Connecticut)H-Index: 5
Last. Bianca Ramos Pezzini (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
view all 7 authors...
Abstract Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints. In this study, formulations LP1 and LP2 were obtained (RTV 100 mg/unit dose) using microcrystalline cellulose (carrier), Kollidon® CL-SF (coating and disintegrating material) and high load (3...
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#1Daiane Anzilaggo (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
view all 5 authors...
Abstract The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomena. However, many factors can influence the performance and success of LS. Therefore this study aimed to evaluate through a factorial design, the factors such as drug state (solution or dispersion), non...
1 CitationsSource
#2Paola Felippi Coelho (UFSC: Universidade Federal de Santa Catarina)
Last. Bianca Ramos Pezzini (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
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The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of the Biopharmaceutics Classification System). One of the most effective strategies to overcome poor dissolution rate and low absorption of drugs is the ...
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#1Brenda De Espíndola (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2Francieli Furlan Bortolon (UFSC: Universidade Federal de Santa Catarina)
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
view all 5 authors...
The USP Apparatus 3 is a compendial dissolution Apparatus that has been mainly used to assess the performance of modified-release drug products. However, this Apparatus can be applied to dissolution testing of immediate-release tablets as well, with several advantages such as lower consumption of dissolution media, reduced setup time in quality control routine, and minimized hydrodynamic issues. In this work, three immediate-release (IR) tablets containing antihypertensive drugs of different Bio...
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#1K. K. S. Skripnik (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2Manoela Klüppel Riekes (UFSC: Universidade Federal de Santa Catarina)H-Index: 8
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
view all 5 authors...
In the absence of an official dissolution method for modified-release tablets of gliclazide, dissolution parameters, such as apparatuses (1, 2, and 3), rotation speeds, pH, and composition of the dissolution medium were investigated. The results show that although the drug presents a pH-mediated solubility (pH 7.0 > 6.8 > 6.4 > 6.0 > 5.5 > 4.5), the in vitro release of the studied tablets was not dependent on this parameter, despite of the apparatus tested. On the other hand, the rotation speed ...
1 CitationsSource
#1Viviane Nart (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
#2André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
Last. Hellen Karine Stulzer (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
view all 6 authors...
Mini-tablets are a new tendency in solid dosage form design for overcoming therapeutic obstacles such as impaired swallowing and polypharmacy therapy. Among their advantages, these systems offer therapeutic benefits such as dose flexibility and combined drug release patterns. The use of lipids in the formulation has also drawn considerable interest as means to modify the drug release from the dosage form. Therefore, this paper aimed at developing sustained release mini-tablets containing the hig...
6 CitationsSource
#1Bianca Ramos Pezzini (USP: University of São Paulo)H-Index: 6
#2André O'Reilly Beringhs (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
Last. Diva Sonaglio (UFSC: Universidade Federal de Santa Catarina)H-Index: 7
view all 6 authors...
Abstract This study evaluated the feasibility of liquisolid pellets as an innovative drug delivery system to improve the dissolution rate of low solubility drugs, combining the advantageous properties of multiple-unit dosage forms and the liquisolid formulations. The effects of crospovidone (Kollidon ® CL-SF) as a coating and disintegrating material (4 or 8%) and the type of non-volatile solvent, PEG 400 or Cremophor ® EL, on the felodipine (model drug) dissolution profile were assessed. All liq...
6 CitationsSource
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