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Mark A. Smith
Davidson College
EndocrinologyPsychologySelf-administrationAnesthesiaMedicine
49Publications
18H-index
1,119Citations
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Publications 50
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Abstract Background The National Institute on Drug Abuse (NIDA) recently released a Request for Information (RFI) soliciting comments on nonhuman animal models of substance use disorders (SUD). Methods A literature review was performed to address the four topics outlined in the RFI and one topic inspired by the RFI: (1) animal models that best recapitulate SUD, (2) animal models that best balance the trade-offs between resources and ecological validity, (3) animal models whose translational valu...
1 CitationsSource
#1Mark A. Smith (Davidson College)H-Index: 18
#2Gaylen E. Fronk (Davidson College)H-Index: 2
Last. Wendy J. Lynch (UVA: University of Virginia)H-Index: 10
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Rationale Preclinical studies consistently report that aerobic exercise decreases drug self-administration and other forms of drug-seeking behavior; however, relatively few studies have examined other types of physical activity.
1 CitationsSource
#1Wendy J. Lynch (UVA: University of Virginia)H-Index: 27
#2Jean M. Abel (UVA: University of Virginia)H-Index: 5
Last. Mark A. Smith (Davidson College)H-Index: 18
view all 4 authors...
Purpose of Review Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its efficacy, from a behavioral to a molecular level, in order to understand the exercise conditions that lead to beneficial effects. We also highlight the few recent findings of sex-specific differences.
2 CitationsSource
#1Wendy J. Lynch (UVA: University of Virginia)H-Index: 27
#2Andrea M. Robinson (Davidson College)H-Index: 3
Last. Mark A. Smith (Davidson College)H-Index: 18
view all 4 authors...
Purpose of Review This report provides an update on clinical and preclinical findings for the efficacy of exercise to prevent substance use disorder with a focus on recent evidence for sex differences and neurobiological mechanisms.
2 CitationsSource
#1Andrea M. Robinson (Davidson College)H-Index: 3
#2Gaylen E. Fronk (Davidson College)H-Index: 2
Last. Mark A. Smith (Davidson College)H-Index: 18
view all 5 authors...
Abstract Background Studies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the effects of social contact on cocaine intake in female rats, (2) examine the behavioral mechanisms by which social contact influences cocaine intake, and (3) examine whether the estrous cycle moderates the effects of social contact on cocaine intake. Methods Female rats were...
4 CitationsSource
#1Justin C. Strickland (UK: University of Kentucky)H-Index: 10
#2Mark A. Smith (Davidson College)H-Index: 18
Source
#1Andrea M. Robinson (Davidson College)H-Index: 3
#2Ryan T. Lacy (F&M: Franklin & Marshall College)H-Index: 8
Last. Mark A. Smith (Davidson College)H-Index: 18
view all 5 authors...
Source
#1Mark A. Smith (Davidson College)H-Index: 18
#2Huailin Zhang (Davidson College)H-Index: 3
Last. Andrea M. Robinson (Davidson College)H-Index: 3
view all 3 authors...
Social partners influence the likelihood of using drugs, developing a substance use disorder, and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of cocaine use over time, and the compulsive patterns of cocaine use that emerge during an extended binge. The purpose of this study was to examine the effects of social cues on the reinstatement of cocaine-seeking behavior after a period of abstinenc...
3 CitationsSource
#1Justin C. Strickland (UK: University of Kentucky)H-Index: 10
#2Mark A. Smith (Davidson College)H-Index: 18
Abstract Background Numerous studies have demonstrated that participation in regular resistance exercise (e.g., strength training) is associated with improvements in mental health, memory, and cognition. However, less is known about the neurobiological mechanisms mediating these effects. The goal of this mini-review is to describe and evaluate the available animal models of resistance exercise that may prove useful for examining CNS activity. New method Various models have been developed to exam...
8 CitationsSource
#1Mark A. Smith (Davidson College)H-Index: 18
#2Gaylen E. Fronk (Davidson College)H-Index: 2
Last. Andrea M. Robinson (Davidson College)H-Index: 3
view all 5 authors...
Abstract Exercise is associated with lower rates of drug use in human populations and decreases drug self-administration in laboratory animals. Most of the existing literature examining the link between exercise and drug use has focused on chronic, long-term exercise, and very few studies have examined the link between exercise output (i.e., amount of exercise) and drug self-administration. The purpose of this study was to examine the effects of acute bouts of exercise on cocaine self-administra...
3 CitationsSource
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