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Yifan Wang
Center for Drug Evaluation and Research
ChemistryPrincipal component analysisMaterial propertiesChromatographyWaste management
29Publications
9H-index
210Citations
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Publications 32
Newest
#1Patrick J. Faustino (CDER: Center for Drug Evaluation and Research)H-Index: 23
#2Andrew J. Brown (A&M: Texas A&M University)H-Index: 6
Last. Adil Mohammad (CDER: Center for Drug Evaluation and Research)H-Index: 5
view all 8 authors...
Abstract There has been a long-standing discussion in the scientific literature on the thallium (Tl) binding capacity of ferric hexacyanoferrate (insoluble) and potassium hexacyanoferrate (soluble) forms of Prussian blue (PB). The literature sometime suggests that the soluble form of PB should be used to treat thallium poisoning, instead of the FDA approved insoluble form of PB. The literature debate is further complicated by the lack of fundamental characterization data such as critical quality...
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#1Yifan Wang (CDER: Center for Drug Evaluation and Research)H-Index: 9
#2Thomas O'Connor (CDER: Center for Drug Evaluation and Research)H-Index: 4
Last. Celia N. Cruz (CDER: Center for Drug Evaluation and Research)H-Index: 4
view all 5 authors...
Abstract The purpose of this study is to establish a material library and discuss its potential application to the development and lifecycle management of a continuous manufacturing process for solid dosage forms. Particularly, this study addresses the importance of selecting process-relevant testing conditions for material characterization, proposes a methodology to capture relevant information with a reduced set of measurements, and correlates material properties with process performance. This...
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#1David N. Powers (CDER: Center for Drug Evaluation and Research)H-Index: 2
#2Yifan Wang (CDER: Center for Drug Evaluation and Research)H-Index: 9
Last. Cyrus Agarabi (CDER: Center for Drug Evaluation and Research)H-Index: 11
view all 9 authors...
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#1Charudharshini Srinivasan (CDER: Center for Drug Evaluation and Research)H-Index: 2
#2Youlong Ma (CDER: Center for Drug Evaluation and Research)
Last. Celia N. Cruz (CDER: Center for Drug Evaluation and Research)H-Index: 4
view all 16 authors...
Abstract Pharmaceutical containers for parenterals have been predominantly manufactured using glass as a packaging material of choice, especially Type-I glass, since it has been regarded as a chemically inert and an effective container closure system (CCS). Nevertheless, there have been reports and recalls related to glass quality issues, such as breakage, flakes, and particles observed in marketed products. The novelty of this research is based on the knowledge gathered from our previously cond...
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#1M. Sebastian Escotet-Espinoza (RU: Rutgers University)H-Index: 5
#2Sara Moghtadernejad (LBSU: California State University, Long Beach)H-Index: 8
Last. Marianthi G. Ierapetritou (RU: Rutgers University)H-Index: 46
view all 12 authors...
Abstract Residence time distribution (RTD) modeling can aid the understanding and characterization of macro-mixing in continuous powder processing unit operations by relating observed behavior to quantitative model parameters. This article is the second part of the work done to characterize the effect of material properties on the measurement of RTDs in continuous powder processing operations. The goal of this paper is to examine the behavior of the RTD given different sets of tracer material pr...
1 CitationsSource
#1M. Sebastian Escotet-Espinoza (RU: Rutgers University)H-Index: 5
#2Sara Moghtadernejad (LBSU: California State University, Long Beach)H-Index: 8
Last. Fernando J. MuzzioH-Index: 52
view all 11 authors...
Abstract Residence time distribution (RTD) models are essential to understand process dynamics and support process monitoring and control in continuous manufacturing systems. RTD models can also be used to monitor material traceability and to isolate intermediate materials or finished products when specifications are not met. However, while pharmaceutical companies are currently making extensive use of RTD approaches, standard methods for conducting, interpreting, and using RTD results in contin...
6 CitationsSource
#1M. Sebastian Escotet-Espinoza (RU: Rutgers University)H-Index: 5
#2Sara Moghtadernejad (RU: Rutgers University)H-Index: 8
Last. Fernando J. Muzzio (RU: Rutgers University)H-Index: 52
view all 10 authors...
Abstract Material properties are known to have a significant impact on pharmaceutical manufacturing performance, particularly for solid product processes. Evaluating the performance of a specific material, for example an active pharmaceutical ingredient or excipient, is critical during development stages in order to determine the impact of material properties on the process. However, materials may be scarce during the early stages of process development due to high cost, unavailability, import r...
8 CitationsSource
#1Sheng Yang (CSU: Central South University)H-Index: 7
#2Qianqian Chen (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Yuhan Sun (CAS: Chinese Academy of Sciences)H-Index: 58
view all 6 authors...
Abstract Methanol is an important platform chemical. The conversion of natural gas is the most widely used technology to produce methanol. With the development of chemical industry, the situation of energy shortage has become very serious. The exploration and adoption of renewable energy is an alternative way to solve the crisis of energy shortage. Wind energy is one of the most prominent energy source among all renewable energy sources in the Chinese energy markets. In this paper, wind energy i...
8 CitationsSource
#1Yi Man (SCUT: South China University of Technology)H-Index: 3
#2Yulin Han (SCUT: South China University of Technology)H-Index: 3
Last. Mengna Hong (SCUT: South China University of Technology)H-Index: 4
view all 7 authors...
Abstract Papermaking is a water intensive industry. The growth of paper demand will further intensify the need of fresh water resources. Papermaking involves complex processing routes. Previous investigations of water consumption in papermaking industry have focused primarily on key processes and pathways, ignoring the impacts of many intermediate and inter-related processes in paper production cycles and there underestimating the sustainability impacts. Herein, the results of a life cycle analy...
7 CitationsSource
#1Sheng Yang (CSU: Central South University)H-Index: 7
#2Yifan Wang (RU: Rutgers University)H-Index: 9
Last. Abdul-Ghani Olabi (University of the West of Scotland)H-Index: 51
view all 6 authors...
Absorption refrigeration (AR) systems have been extensively used for utilizing waste heat from industrial plants. In this paper, a novel cascade absorption refrigeration (NCAR) is proposed to produce −40 °C cold energy via using low-grade waste heat. The developed system consists of an NH3/H2O AR cycle and LiBr/H2O AR cycle. A simulation study is conducted, on the basis of the revised model built in Aspen Plus. The impacts of feed concentration, generator temperature, low-pressure part pressure,...
5 CitationsSource
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