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Octavio L. Franco
Universidade Católica de Brasília
409Publications
41H-index
6,528Citations
Publications 413
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Bacterial infections represent a major worldwide health problem, with an special highlight on Gram-negative bacteria, which were assigned by the World Health Organization (WHO) as the most critical priority for development of novel antimicrobial compounds. Antimicrobial peptides (AMPs) have been considered as potential alternative agents for treating these infections. Here we demonstrated the broad-spectrum activity of EcDBS1R6, a peptide derived from a signal peptide sequence of Escherichia col...
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#1Sudip SomeH-Index: 2
#2Onur Bulut (METU: Middle East Technical University)H-Index: 2
Last.Ismail Ocsoy (Erciyes University)H-Index: 22
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Herein, we report the synthesis of silver nanoparticles (AgNPs) by a green route using the aqueous leaf extract of Morus indica L. V1. The synthesized AgNPs exhibited maximum UV-Vis absorbance at 460 nm due to surface plasmon resonance. The average diameter (~54 nm) of AgNPs was measured from HR-TEM analysis. EDX spectra also supported the formation of AgNPs, and negative zeta potential value (−14 mV) suggested its stability. Moreover, a shift in the carbonyl stretching (from 1639 cm−1 to 1630 c...
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The Indianmeal moth, Plodia interpunctella, is one of the most damaging pests of stored products. We investigated the insecticidal properties of ApKTI, a Kunitz trypsin inhibitor from Adenanthera pavonina seeds, against P. interpunctella larvae through bioassays with artificial diet. ApKTI-fed larvae showed reduction of up to 88% on larval weight and 75% in survival. Trypsin enzymes extracted from P. interpunctella larvae were inhibited by ApKTI, which also demonstrated capacity to bind to chiti...
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#1L.L.S. Monteiro (UCB: Universidade Católica de Brasília)H-Index: 1
#2Octavio L. Franco (UCB: Universidade Católica de Brasília)H-Index: 41
Last.William F. Porto (UCDB: Universidade Católica Dom Bosco)H-Index: 15
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Abstract The glucocorticoid resistance hereditary condition may emerge from the occurrence of point mutations in the glucocorticoid receptor (GR), which could impair its functionality. Because the main feature of such pathology is the resistance of the hypothalamic-pituitary-adrenal axis to the hormone cortisol, we used the GR ligand binding domain three-dimensional structure to perform computational analysis for eight variants known to cause this clinical condition (I559 N, V571A, D641V, G679S,...
1 CitationsSource
#1Fabiani L. R. Beal (UCB: Universidade Católica de Brasília)
#2Pedro R. Beal (UnB: University of Brasília)
Last.Osmar N. SilvaH-Index: 17
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