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Sandip Pravin Patel
University of California, San Diego
95Publications
16H-index
1,563Citations
Publications 100
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Rapid advances in the utility of molecular testing to identify common and uncommon driver mutations as well as the expeditious rate of drug development have intensified the need to obtain multiplex next generation sequencing from tissue and/or blood at the time of diagnosis in order to determine the most appropriate treatment for patients with advanced lung cancers. In this review, we discuss the currently available investigational targeted therapies for the treatment of sensitizing epidermal gr...
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Background: Mesothelin, a GPI-anchored cell surface protein, is highly expressed in several tumor types and can be targeted for antibody (ab)-based cancer therapy. BMS-986148 is a fully human IgG1 anti-mesothelin monoclonal ab conjugated to tubulysin to promote selective cytotoxic delivery to tumor cells. In preclinical models, combination of anti–mesothelin-tubulysin with anti–PD-1 promoted a synergistic antitumor response and influx of tumor-infiltrating lymphocytes. Here, we present initial d...
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#1Leora Horn (Vandy: Vanderbilt University)H-Index: 44
#2Jennifer G. Whisenant (Vandy: Vanderbilt University)H-Index: 11
Last.Christine M. Lovly (Vandy: Vanderbilt University)H-Index: 33
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Abstract Introduction Despite initial effectiveness of ALK tyrosine kinase inhibitors (TKIs) in patients with ALK+ non-small cell lung cancer (NSCLC), therapeutic resistance will ultimately develop. Serial tracking of genetic alterations detected in circulating tumor DNA (ctDNA) can be an informative strategy to identify response and resistance. This study evaluated the utility of analyzing ctDNA as a function of response to ensartinib, a potent second-generation ALK TKI. Methods Pre-treatment p...
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#1Karen L. Reckamp (City of Hope National Medical Center)H-Index: 40
#2Wallace Akerley (HCI: Huntsman Cancer Institute)H-Index: 39
Last.Melissa Lynne JohnsonH-Index: 12
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#1May Cho (UC Davis: University of California, Davis)H-Index: 7
#2Johanna C. Bendell (Sarah Cannon Research Institute)H-Index: 38
Last.Sandip Pravin Patel (UCSD: University of California, San Diego)H-Index: 16
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