C. Jessica E. Metcalf
Princeton University
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Publications 93
#1Malavika RajeevH-Index: 2
Last. Katie HampsonH-Index: 31
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#2Bruno Masquelier (UCL: Université catholique de Louvain)H-Index: 7
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ABSTRACTBackground: Seasonal patterns of mortality have been identified in Sub-Saharan Africa but their changes over time are not well documented.Objective: Based on death notification data from An...
#1Norma M. Morella (University of California, Berkeley)H-Index: 3
#2Francis Cheng-Hsuan Weng (AS: Academia Sinica)H-Index: 2
Last. Britt Koskella (University of California, Berkeley)H-Index: 23
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There is increasing interest in the plant microbiome as it relates to both plant health and agricultural sustainability. One key unanswered question is whether we can select for a plant microbiome that is robust after colonization of target hosts. We used a successive passaging experiment to address this question by selecting upon the tomato phyllosphere microbiome. Beginning with a diverse microbial community generated from field-grown tomato plants, we inoculated replicate plants across 5 plan...
2 CitationsSource
#1Marjolein Bruijning (Princeton University)H-Index: 3
#2C. Jessica E. Metcalf (Princeton University)H-Index: 25
Last. Julien F. Ayroles (Princeton University)H-Index: 21
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Genetically identical individuals can be phenotypically variable, even in constant environmental conditions. The ubiquity of this phenomenon, known as ‘intra-genotypic variability’, is increasingly evident and the relevant mechanistic underpinnings are beginning to be understood. In parallel, theory has delineated a number of formal expectations for contexts in which such a feature would be adaptive. Here, we review empirical evidence across biological systems and theoretical expectations, inclu...
2 CitationsSource
#1Ian F. Miller (Princeton University)H-Index: 1
#2C. Jessica E. Metcalf (Princeton University)H-Index: 25
Many vaccines have heterogeneous effects across individuals. Additionally, some vaccines do not prevent infection, but reduce disease-associated mortality and transmission. Both of these factors wi...
#1Rachel E. Baker (Princeton University)
#2Ayesha Mahmud (University of California, Berkeley)H-Index: 3
Last. Bryan T. Grenfell (Princeton University)H-Index: 78
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A key question for infectious disease dynamics is the impact of the climate on future burden. Here, we evaluate the climate drivers of respiratory syncytial virus (RSV), an important determinant of disease in young children. We combine a dataset of county-level observations from the US with state-level observations from Mexico, spanning much of the global range of climatological conditions. Using a combination of nonlinear epidemic models with statistical techniques, we find consistent patterns ...
#1Amy WinterH-Index: 6
#1Malavika Rajeev (Princeton University)H-Index: 2
#2Glenn T EdosoaH-Index: 2
Last. Katie Hampson (Glas.: University of Glasgow)H-Index: 31
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Abstract In Madagascar, dog-mediated rabies has been endemic for over a century, however there is little data on its incidence or impact. We collected data over a 16-month period on provisioning of post-exposure prophylaxis (PEP) at a focal clinic in the Moramanga District and determined the rabies status of biting animals using clinical and laboratory diagnosis. We find that animal rabies cases are widespread, and clinic-based triage and investigation are effective ways to increase detection of...
3 CitationsSource
#1C. Jessica E. Metcalf (Princeton University)H-Index: 25
#2Britt Koskella (University of California, Berkeley)H-Index: 23
The evolution of host immunity occurs in the context of the microbiome, but little theory exists to predict how resistance against pathogens might be influenced by the need to tolerate and regulate commensal microbiota. We present a general model to explore the optimal investment in host immunity under conditions in which the host can, versus cannot easily distinguish among commensal versus pathogenic bacteria, and when commensal microbiota can, versus cannot protect the host against the impacts...
1 CitationsSource
#1Brooke A. Bozick (Princeton University)
#2Colin J. Worby (Princeton University)H-Index: 11
Last. C. Jessica E. Metcalf (Princeton University)H-Index: 25
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Abstract Rubella virus causes mild disease in children but for women in the early stages of pregnancy, it can cause spontaneous abortion, congenital rubella syndrome (CRS) and associated birth defects. Despite the availability of an effective vaccine, rubella virus continues to circulate endemically in several regions of the world. This is particularly true in East and Southeast (E/SE) Asia, where control efforts vary widely among countries that are well connected through travel and immigration....