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Winston Ciridon
University of Washington
Surface modificationOrganic chemistryMaterials scienceIonomerProtein adsorption
4Publications
4H-index
65Citations
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Publications 6
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#1Courtney Cottone (UCI: University of California, Irvine)H-Index: 1
#2Sherry Lu (UCI: University of California, Irvine)
Last. Kathleen R. Johnson (UCI: University of California, Irvine)H-Index: 22
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INTRODUCTION: Encrustation of implanted urinary tract devices is associated with significant morbidity. Pellethane(R) is a polyether-based compound noted for its strength, porosity and resistance to solvents. We assessed Pellethane(R) thermoplastic polyurethane (TPU) with and without surface coatings 2-hydroxyethyl methacrylate (HEMA) and tetraethylene glycol dimethyl ether (TETRA) for the potential to resist encrustation in an artificial urine environment. METHODS: Samples of Pellethane(R) TPU,...
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#1Razieh Khalifehzadeh (UW: University of Washington)H-Index: 2
#2Winston Ciridon (UW: University of Washington)H-Index: 4
Last. Buddy D. Ratner (UW: University of Washington)H-Index: 88
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Abstract Surface-induced thrombosis is still a significant clinical concern for many types of blood-contacting medical devices. In particular, protein adsorption and platelet adhesion are important events due to their ability to trigger the coagulation cascade and initiate thrombosis. Poly(lactic acid) (PLA) has been the predominant polymer used for making bioresorbable stents. Despite long-term advantages, these stents are associated with higher rates of early thrombosis compared with permanent...
5 CitationsSource
#1Jason D. Whittle (UniSA: University of South Australia)H-Index: 20
#2Robert D. Short (UniSA: University of South Australia)H-Index: 45
Last. Andrew Michelmore (UniSA: University of South Australia)H-Index: 25
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This multi-centre investigation explores the variability that results from using the power/flow rate ratio (W/F) to describe plasma treatment and plasma polymerization processes. Results from fourteen reactors of different design and spread across ten laboratories, showed that the chemistry of the treated and deposited polymer/plasma polymer films is highly variable between reactor systems, and that there was no clear pattern linking these variations to other properties of the reactor systems (e...
25 CitationsSource
#1Thelma I. Valdes (University of Connecticut Health Center)H-Index: 2
#2Winston Ciridon (UW: University of Washington)H-Index: 4
Last. James D. Bryers (UW: University of Washington)H-Index: 31
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An ideal surface for implantable glucose sensors would be able to evade the events leading to chronic inflammation and fibrosis, thereby extending its utility in an in vivo environment. Nafion™, a perfluorinated ionomer, is the membrane material preferred for in situ glucose sensors. Unfortunately, the surface properties of Nafion™ promote random protein adsorption and eventual foreign body encapsulation, thus leading to loss of glucose signal over time. Details of the techniques to render Nafio...
5 CitationsSource
#1Thelma I. Valdes (University of Connecticut Health Center)H-Index: 2
#2Winston Ciridon (UW: University of Washington)H-Index: 4
Last. James D. Bryers (UW: University of Washington)H-Index: 31
view all 4 authors...
Nafion™ is the membrane material preferred for in situ glucose sensors. Unfortunately, surface properties of Nafion promote random protein adsorption and eventual foreign body encapsulation thus leading to loss of glucose signal over time. Here we detail surface modifications made by RF plasma deposition to Nafion with the intent to prevent random protein adsorption while providing enough functional sites (hydroxyl groups) to bind a biologically active peptide known to induce cellular adhesion (...
30 CitationsSource
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