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Juan J. Torrado
Complutense University of Madrid
PharmacokineticsChemistryAmphotericin BChromatographyPharmacology
76Publications
24H-index
1,657Citations
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Publications 82
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#1Juan J. Torrado (Complutense University of Madrid)H-Index: 24
#2Dolores R. Serrano (Complutense University of Madrid)H-Index: 10
Last. Javier CapillaH-Index: 22
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Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in m...
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#1Pablo Bilbao-RamosH-Index: 9
#2Dolores R. SerranoH-Index: 10
view all 6 authors...
Leishmaniasis affects around 12 million people worldwide and is estimated to cause the ninth-largest disease burden. There are three main forms of the disease, visceral (VL), cutaneous (CL), and mucocutaneous (MCL), leading to more than one million new cases every year and several thousand deaths. Current treatments based on chemically synthesized molecules are far from ideal. In this study, we have tested the in vitro and in vivo efficacy of ursolic acid (UA), a multifunctional triterpenoid wit...
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#1Antonio Matji (Complutense University of Madrid)H-Index: 2
#2Emilio Vargas (Complutense University of Madrid)H-Index: 7
Last. Dolores R. Serrano (Complutense University of Madrid)H-Index: 10
view all 8 authors...
The bioequivalence of a new ibuprofen 600-mg film-coated tablet obtained by roller compaction was studied in a crossover study with 22 healthy volunteers. Bioequivalence was analyzed based on (a) the S-enantiomer, (b) the R-enantiomer, and (c) the sum of both enantiomers (representing the results of an achiral assay). The bioequivalence conclusion for ibuprofen products should be based not only on AUC and Cmax but also on tmax since tmax is related to the onset of action. However, it is not poss...
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#1José Ignacio Manzano (CSIC: Spanish National Research Council)H-Index: 9
#2Eduardo J. Cueto-Díaz (CSIC: Spanish National Research Council)H-Index: 2
Last. Christophe Dardonville (CSIC: Spanish National Research Council)H-Index: 18
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We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in the submicromolar range (EC50 from 0.04 to 0.28 μM, SI > 10) against the protozoan parasite Leishmania donovani. The pharmacokinetics and in vivo oral efficacy of compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl)triphenylphosphonium bromide] in a mouse model of visceral leishmaniasis were established. Compound 1 reduced the parasite load in spleen (98.9%) and liver (95.3%) of infected mice after an oral do...
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#1Chiara Borsari (University of Modena and Reggio Emilia)H-Index: 6
#2María Dolores Jiménez-Antón (Complutense University of Madrid)H-Index: 1
Last. Maria Paola Costi (University of Modena and Reggio Emilia)H-Index: 19
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Abstract Leishmaniasis, a major health problem worldwide, has a limited arsenal of drugs for its control. The appearance of resistance to first- and second-line anti-leishmanial drugs confirms the need to develop new and less toxic drugs that overcome spontaneous resistance. In the present study, we report the design and synthesis of a novel library of 38 flavonol-like compounds and their evaluation in a panel of assays encompassing parasite killing, pharmacokinetics, genomics and ADME-Toxicity ...
2 CitationsSource
#2Dolores R. SerranoH-Index: 10
Last. Javier CapillaH-Index: 22
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Invasive pulmonary aspergillosis represents one of the most serious fungal infections among immunocompromised patients. In this study, we aimed to analyze the in vivo efficacy of prophylactic oral amphotericin B (AMB) encapsulated in modified chitosan-nanoparticles (Nanomerics’ Molecular Envelope Technology (MET)) supplemented with a standardized extract of cultured Lentinula edodes mycelia (AHCC®) in a murine model of pulmonary aspergillosis. We determined fungal burden and survival of mice and...
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#1Antonio Matji (Complutense University of Madrid)H-Index: 2
#2Nicoletta Donato (Complutense University of Madrid)H-Index: 1
Last. Juan J. Torrado (Complutense University of Madrid)H-Index: 24
view all 9 authors...
We would like to thank Industrial Farmaceutica Cantabria (Torrejon, Spain) for their support and assistance to perform this work. This study was partially supported by the Complutense University of Madrid and a Science Foundation Ireland grant co-funded under the European Regional Development Fund (SFI/12/RC/2275) provided to Prof. A. M. Healy
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#1Chiara Borsari (University of Modena and Reggio Emilia)H-Index: 6
#2Nuno Santarém (University of Porto)H-Index: 14
Last. Maria Paola Costi (University of Modena and Reggio Emilia)H-Index: 19
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Chemical modulation of the flavonol 2-(benzo[d][1,3]dioxol-5-yl)-chromen-4-one (1), a promising anti-Trypanosomatid agent previously identified, was evaluated through a phenotypic screening approach. Herein, we have performed structure–activity relationship studies around hit compound 1. The pivaloyl derivative (13) showed significant anti-T. brucei activity (EC50 = 1.1 μM) together with a selectivity index higher than 92. The early in vitro ADME-tox properties (cytotoxicity, mitochondrial toxic...
1 CitationsSource
#1Dolores R. Serrano (Complutense University of Madrid)H-Index: 10
#2María José Gordo (Complutense University of Madrid)
Last. Juan J. Torrado (Complutense University of Madrid)H-Index: 24
view all 6 authors...
Hydroquinone (HQ) is an anti-hyperpigmentation agent with poor physicochemical stability. HQ formulations are currently elaborated by compounding in local pharmacies. Variability in the characteristics of HQ topical formulations can lead to remarkable differences in terms of their stability, efficacy, and toxicity. Four different semisolid O/W formulations with 5% HQ were prepared using: (i) Beeler´s base plus antioxidants (F1), (ii) Beeler´s base and dimethyl isosorbide (DMI) as solubiliser (F2...
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Amphotericin B is a low soluble broad-spectrum antifungal agent. Cyclodextrins can be added to amphotericin formulations to enhance both their solubility and antifungal properties. Semisolid amphotericin formulations containing gamma cyclodextrin (AGCD) were prepared and compared with two reference formulations—one of them without any solubility enhancer (A) and the other with DMSO (ADMSO). Rheological, the permeability through hairless mouse skin and antifungal characteristics of the different ...
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