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Sien Lin
The Chinese University of Hong Kong
EndocrinologyMaterials scienceMesenchymal stem cellStem cellBiology
55Publications
16H-index
751Citations
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Publications 54
Newest
#1Yanhua Yang (CUHK: The Chinese University of Hong Kong)H-Index: 3
#1Yang Y (CUHK: The Chinese University of Hong Kong)
Last. Yunzhi Peter Yang (Stanford University)H-Index: 6
view all 12 authors...
BACKGROUND: Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to accelerate bone formation in DO. However, the optimal time point for cell therapy in DO remains unknown. This study sought to determine the optimal time point of cell administration to achieve early bone consolidation in DO. We hypothesized that the ratio of circulating MSCs to...
1 CitationsSource
#1Zhuming ChenH-Index: 2
#2Huan ZhongH-Index: 1
Last. Jiaqi ChuH-Index: 5
view all 12 authors...
Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1β and IL-18, leading to the aggravation of the downstream inflammatory response. Nrf2 is a key transcription factor that regulates the expression of antioxidant enzymes that protect against oxidative stress and tissue da...
2 CitationsSource
#1Rui Li (CUHK: The Chinese University of Hong Kong)H-Index: 9
#2Sien Lin (CUHK: The Chinese University of Hong Kong)H-Index: 16
Last. Liming BianH-Index: 27
view all 9 authors...
Noncanonical Wnt signaling in stem cells is essential to numerous developmental events. However, no prior studies have capitalized on the osteoinductive potential of noncanonical Wnt ligands to functionalize biomaterials in enhancing the osteogenesis and associated skeleton formation. Here, we investigated the efficacy of the functionalization of biomaterials with a synthetic Wnt5a mimetic ligand (Foxy5 peptide) to promote the mechanosensing and osteogenesis of human mesenchymal stem cells by ac...
4 CitationsSource
#1Jianping HuangH-Index: 5
#2Haixing Wang (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Sien LinH-Index: 16
view all 14 authors...
Anti-resorptive agents like bisphosphonates have been widely used for the treatment of postmenopausal osteoporosis. However, their long-term safety and efficacy are still controversial. This study is to examine the effect of Asiatic acid (AA) in osteoclastic differentiation, and further to investigate its effect on bone quality in animals. Effect of AA on osteoclastic differentiation was measured by Tartrate-resistant acid phosphatase stain, bone resorption pit assays, and quantitative real-time...
Source
#1Xiaoyu Chen (CUHK: The Chinese University of Hong Kong)H-Index: 12
#2Rui Li (CUHK: The Chinese University of Hong Kong)H-Index: 9
Last. Liming BianH-Index: 27
view all 21 authors...
Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) with improved efficiency. We further investigate the impact of the dynamic molecular conformational change of SCNGs on cellular interactions from molecular to bulk scale. First, the supramolecular unfoldable SCNGs efficiently deliver siRNAs into stem cells as a molecular drug carrier in a conformation-depen...
14 CitationsSource
#1Jianbin Xu (SRRSH: Sir Run Run Shaw Hospital)H-Index: 63
#1Jianbin Xu (SRRSH: Sir Run Run Shaw Hospital)H-Index: 2
Last. Liming Bian (CUHK: The Chinese University of Hong Kong)H-Index: 27
view all 16 authors...
Abstract Hydrogels have been widely used as the carrier material of therapeutic cell and drugs for articular cartilage repair. We previously demonstrated a unique host-guest macromer (HGM) approach to prepare mechanically resilient, self-healing and injectable supramolecular gelatin hydrogels free of chemical crosslinking. In this work, we show that compared with conventional hydrogels our supramolecular gelatin hydrogels mediate more sustained release of small molecular (kartogenin) and protein...
21 CitationsSource
#1Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 5
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 44
view all 14 authors...
Fracture remains one of the most common traumatic conditions in orthopedic surgery. The use of mesenchymal stem cells (MSCs) to augment fracture repair is promising. Leucine-rich repeat-containing ...
3 CitationsSource
#1Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 5
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 44
view all 8 authors...
Abstract Background A promising approach of bone repair is to use stem cells, such as mesenchymal stem cells (MSCs). Seeking available source of MSCs still remains a great challenge in tissue engineering and cell therapy. Peripheral blood (PB) emerges as an alternative source of MSCs which can be easily acquired with minimal invasiveness. This study was undertaken to evaluate the multipotency of PB-MSCs and effects of human PB-MSCs transplantation on ectopic bone regeneration in nude mice. Metho...
4 CitationsSource
#1Sien Lin (CUHK: The Chinese University of Hong Kong)H-Index: 16
#2Liao CuiH-Index: 14
Last. Wayne Y.W. Lee (CUHK: The Chinese University of Hong Kong)H-Index: 19
view all 14 authors...
Abstract Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tr...
8 CitationsSource
#1Siu Hong Dexter Wong (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2Bohan Yin (CUHK: The Chinese University of Hong Kong)H-Index: 3
Last. Liming BianH-Index: 27
view all 12 authors...
3 CitationsSource
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