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J. John Mann
Columbia University
1,438Publications
142H-index
95.7kCitations
Publications 1446
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#1Honglei Yin (Southern Medical University)
#2Hanga Galfalvy (Columbia University)H-Index: 33
Last.Na Yan (Southern Medical University)
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Abstract Background Previously, we reported that the longest variant of the GABA A receptor γ2 subunit (GABRG2) was associated with suicidal behavior. The present study therefore aimed to determine whether polymorphisms near the alternatively spliced exon of GABRG2 are associated with suicide attempt (SA) and its related traits, and how these variants might interact with reported childhood trauma (CT) in their association with suicidal behavior. Methods We examined 5 single nucleotide polymorphi...
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#1Judith WeissmanH-Index: 8
#2David Russell (ASU: Appalachian State University)H-Index: 10
Last.J. John Mann (Columbia University)H-Index: 142
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Economic recessions have been well studied in relationship to poor mental health. However, subjective financial worries have not been examined relative to serious psychological distress (SPD), a measure of poor mental health. Adults 18 to 64 years in the cross-sectional 2016 National Health Interview Survey (n = 24,126) were examined for worries about paying for bills, serious medical events, expected medical costs, retirement, children’s college tuition and maintaining a standard of living; by ...
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#1J.S. Dileep KumarH-Index: 20
#2Jaya Prabhakaran (CUMC: Columbia University Medical Center)H-Index: 14
Last.Kiran Kumar Solingapuram Sai (Wake Forest University)H-Index: 9
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Abstract Altered dynamics of microtubules (MT) are implicated in the pathophysiology of a number of brain diseases. Therefore, radiolabeled MT targeted ligands that can penetrate the blood brain barrier (BBB) may offer a direct and sensitive approach for diagnosis, and assessing the clinical potential of MT targeted therapeutics using PET imaging. We recently reported two BBB penetrating radioligands, [11C]MPC-6827 and [11C]HD-800a s specific PET ligands for imaging MTs in brain. The major metab...
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#1Barbara Stanley (Columbia University)H-Index: 47
#2J. John Mann (Columbia University)H-Index: 142
Suicide rates have continued to rise in the United States. Speculations for this rise proliferate but the causes for the increase remain unknown. While research focuses on identifying causes, the health care system is an important site for identification of patients at risk. Forty percent of individuals who die by suicide were seen in primary care in the month prior to suicide. The Zero Suicide model describes a comprehensive approach for health care systems to aid in identification and interven...
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#1Bin Dong (Nathan Kline Institute for Psychiatric Research)H-Index: 1
#2Borehalli M. Shilpa (Dr. Hari Singh Gour University)H-Index: 1
Last.K. Yaragudri Vinod (NYU: New York University)H-Index: 16
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Abstract Major depressive disorder (MDD) is common, often under-treated and a leading cause of disability and mortality worldwide. The causes of MDD remain unclear, including the role of the endocannabinoid system. Intriguingly, the prevalence of depression is significantly greater in women than men. In this study we examined the role of endocannabinoids in depressive behavior. The levels of endocannabinoids, N-arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG) were measured alon...
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Abstract Suicidal behavior is a major cause of morbidity and mortality in psychiatric illness. However, only a subset of patients with psychiatric illnesses, such as major depressive disorder (MDD), commit suicide. This raises the question of how those who manifest suicidal behavior differ from those who do not. In the context of a stress-diathesis model of suicidal behavior, the reaction to stress has often been overlooked. The hypothalamic-pituitary-adrenal (HPA) axis dysfunction is proposed a...
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#1Fabrice Chimienti (CNRS: Centre national de la recherche scientifique)H-Index: 1
#2Laurent CavarecH-Index: 2
Last.Dinah Weissmann (CNRS: Centre national de la recherche scientifique)H-Index: 18
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Phosphodiesterases (PDE) are key modulators of signal transduction and are involved in inflammatory cell activation, memory and cognition. There is a two-fold decrease in the expression of phosphodiesterase 8A (PDE8A) in the temporal cortex of major depressive disorder (MDD) patients. Here, we studied PDE8A mRNA-editing profile in two architectonically distinct neocortical regions in a clinically well-characterized cohort of age- and sex-matched non-psychiatric drug-free controls and depressed s...
1 CitationsSource
#1Michael F. Grunebaum (CUMC: Columbia University Medical Center)H-Index: 35
#2Hanga Galfalvy (Columbia University)H-Index: 33
Last.J. John Mann (CUMC: Columbia University Medical Center)H-Index: 142
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#1Miao-Miao Zhao (Capital Medical University)
#2Jeremy D. Krebs (University of Otago)H-Index: 16
Last.Jin-Kui Yang (Capital Medical University)H-Index: 16
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Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. Using a case-control approach we studied 617 subjects with 13C-urea breath test (13C-UBT) values ≥10‰ who were defined as being positive for H. pylori (cases), while 617 sex and age- matched subjects with 13C-UBT values ≤1‰ were defined as H. pylo...
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#1Fabrice Chimienti (CNRS: Centre national de la recherche scientifique)H-Index: 1
#2Laurent CavarecH-Index: 2
Last.Dinah Weissmann (CNRS: Centre national de la recherche scientifique)H-Index: 18
view all 9 authors...
Author forgot to attach a supplementary doc file which includes the supplementary methods and supplementary figure legends.
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