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J. John Mann
Columbia University
810Publications
108H-index
39.9kCitations
Publications 810
Newest
Published on Feb 15, 2019in Translational Psychiatry5.18
Fabrice Chimienti (CNRS: Centre national de la recherche scientifique), Laurent Cavarec2
Estimated H-index: 2
+ 6 AuthorsDinah Weissmann18
Estimated H-index: 18
(CNRS: Centre national de la recherche scientifique)
Phosphodiesterases (PDE) are key modulators of signal transduction and are involved in inflammatory cell activation, memory and cognition. There is a two-fold decrease in the expression of phosphodiesterase 8A (PDE8A) in the temporal cortex of major depressive disorder (MDD) patients. Here, we studied PDE8A mRNA-editing profile in two architectonically distinct neocortical regions in a clinically well-characterized cohort of age- and sex-matched non-psychiatric drug-free controls and depressed s...
Published on Mar 14, 2019in Translational Psychiatry5.18
Fabrice Chimienti (CNRS: Centre national de la recherche scientifique), Laurent Cavarec2
Estimated H-index: 2
+ 6 AuthorsDinah Weissmann18
Estimated H-index: 18
(CNRS: Centre national de la recherche scientifique)
Author forgot to attach a supplementary doc file which includes the supplementary methods and supplementary figure legends.
Published on Oct 1, 2019in Journal of Affective Disorders4.08
Manesh Gopaldas (Columbia University), Francesca Zanderigo10
Estimated H-index: 10
(Columbia University)
+ 8 AuthorsJ. John Mann108
Estimated H-index: 108
(Columbia University)
Abstract BACKGROUND Serotonin transporter (5-HTT) binding and polyunsaturated fatty acids (PUFAs) are implicated in major depressive disorder (MDD). Links between the two systems in animal models have not been investigated in humans. METHODS Using positron emission tomography (PET) and [ 11 C]DASB, we studied relationships between 5-HTT binding potential and plasma levels of PUFAs docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) in medication-free MDD patients (...
Published in Journal of Psychiatric Research3.92
Michael F. Grunebaum2
Estimated H-index: 2
(CUMC: Columbia University Medical Center),
Hanga Galfalvy31
Estimated H-index: 31
(Columbia University)
+ -3 AuthorsJ. John Mann108
Estimated H-index: 108
(CUMC: Columbia University Medical Center)
Abstract Ketamine shows promise as a rapidly-acting treatment for depression and suicidal ideation, but side effects and abuse potential limit its use. Understanding its mechanism of action could help develop analogous but safer drugs. This post hoc study explored relationships of ketamine and metabolites, including hydroxynorketamine enantiomers, (2S,6S)- and (2R,6R)-HNK, to clinical response in a subgroup from a published trial in suicidal depression. Depressed adults with clinically significa...
Published on Jul 1, 2019in Psychiatry Research-neuroimaging2.21
Barbara Stanley46
Estimated H-index: 46
(Columbia University),
Christina A. Michel2
Estimated H-index: 2
(Columbia University)
+ 5 AuthorsJ. John Mann108
Estimated H-index: 108
(Columbia University)
Abstract While prominent models of suicidal behavior emphasize the hypothalamic- pituitary-adrenal (HPA) axis dysregulation, studies examining its role have yielded contradictory results. One possible explanation is that suicide attempters are a heterogeneous group and HPA axis dysregulation plays a more important role only in a subset of suicidal individuals. HPA axis dysregulation also plays a role in impulsivity and aggression. We hypothesize subgroups of attempters, based on levels of impuls...
Published on Jul 1, 2019in European Neuropsychopharmacology4.47
L. Holper (UZH: University of Zurich), Dorit Ben-Shachar31
Estimated H-index: 31
(Rappaport Faculty of Medicine),
J. John Mann108
Estimated H-index: 108
(Columbia University)
Abstract Mitochondrial complex I (NADH-dehydrogenase) and complex IV (cytochrome-c-oxidase) are reported to be affected by drugs used to treat psychiatric or neurodegenerative diseases, including antidepressants, antipsychotics, anxiolytics, mood stabilizers, stimulants, antidementia, and antiparkinsonian drugs. We conducted meta-analyses examining the effects of each drug category on complex I and IV. The electronic databases Pubmed, EMBASE, CENTRAL, and Google Scholar were searched for studies...
Published on Sep 1, 2019in European Psychiatry3.94
Leah Shelef6
Estimated H-index: 6
,
Anat Brunstein Klomek19
Estimated H-index: 19
(Interdisciplinary Center Herzliya)
+ 3 AuthorsGil Zalsman29
Estimated H-index: 29
(TAU: Tel Aviv University)
Abstract Background There is an ongoing debate on the effectiveness of suicidal behavior prevention measures in the military. The association of three widely used tools with severe suicide attempts was assessed in this setting. Methods Thirty-nine Israeli soldiers (59% males), mean age 19 yrs., who attempted suicide during military service were divided into two groups: severe (n = 14; 35.9%) and moderate suicide attempts, and were assessed using the Scale for Suicide Ideation (SSI), Suicide Inte...
Published on Mar 9, 2018in Journal of Cerebral Blood Flow and Metabolism6.04
Rajapillai L. I. Pillai2
Estimated H-index: 2
(SBU: Stony Brook University),
Mengru Zhang2
Estimated H-index: 2
(SBU: Stony Brook University)
+ 4 AuthorsChristine DeLorenzo16
Estimated H-index: 16
(SBU: Stony Brook University)
In most positron emission tomography (PET) molecular brain imaging studies, regions of interest have been defined anatomically and examined in isolation. However, by defining regions based on physiology and examining relationships between them, we may derive more sensitive measures of receptor abnormalities in conditions such as major depressive disorder (MDD). Using an average of 52 normalized binding potential maps, acquired using radiotracer [11C]-WAY100635 and full arterial input analysis, w...
Published on May 21, 2019in Depression and Anxiety4.93
Lisa Holper1
Estimated H-index: 1
,
Lisa Holper (Columbia University)+ 3 AuthorsJ. John Mann108
Estimated H-index: 108
Jaya Prabhakaran14
Estimated H-index: 14
(CUMC: Columbia University Medical Center),
Christine DeLorenzo16
Estimated H-index: 16
(SBU: Stony Brook University)
+ -3 AuthorsRamin V. Parsey28
Estimated H-index: 28
(SBU: Stony Brook University)
Purpose: 5-HT 2A R exists in high and low affinity states. Agonist PET tracers measure binding to the active high affinity site and thus provide a functionally relevant measure of the receptor. Limited in vivo data have been reported so far for a comparison of agonist versus antagonist tracers for 5-HT 2A R used as a proof of principle for measurement of high and low affinity states of this receptor. We compared the in vivo binding of [ 11 C]CIMBI-5, a 5-HT 2A R agonist, and of the antagonist [ ...
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