Sandra Kallert
University of Basel
CD8ImmunologyT cellBiologyImmune system
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Publications 8
#2Tamara ThelemannH-Index: 1
Last. Frank JaschinskiH-Index: 2
view all 12 authors...
#1Klaus OrlingerH-Index: 8
#2Weldy V. Bonilla (University of Basel)H-Index: 7
Last. Daniel D. Pinschewer (University of Basel)H-Index: 33
view all 12 authors...
e14297Background: The induction of powerful CD8+ T cell immunity to tumor associated self-antigens (TAAs) represents a critical yet challenging goal. Here we report on the development of an arenavi...
#1Tamara HilmenyukH-Index: 3
#2Sandra Kallert (University of Basel)H-Index: 4
Last. Frank JaschinskiH-Index: 2
view all 8 authors...
During the last decades it became obvious that the immune system can be utilized to evoke effective antitumor responses. However, cancer cells develop mechanisms to circumvent this. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to immunosuppressive adenosine. CD39 and CD73 are expressed on different immune cells as well as on a range of cancer cells and the latter are recognized to co-opt both ectonucelo...
2 CitationsSource
#1Elise Dalmas (University of Basel)H-Index: 8
#2Frank M. Lehmann (University of Basel)H-Index: 2
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 21 authors...
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
28 CitationsSource
#1Sandra Kallert (University of Basel)H-Index: 4
#2Stephanie Darbre (University of Geneva)H-Index: 4
Last. Daniel D. Pinschewer (University of Basel)H-Index: 33
view all 15 authors...
Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.
10 CitationsSource
#1Stephanie Darbre (University of Geneva)H-Index: 4
#2Susan Johnson (University of Geneva)H-Index: 4
Last. Daniel D. Pinschewer (University of Basel)H-Index: 33
view all 6 authors...
Recombinant glycoprotein-deficient lymphocytic choriomeningitis virus-based vaccine vectors (rLCMV/ΔGP) are potent CD8(+) T cell inducers. To investigate the underlying molecular requirements, we generated a nucleoprotein-deficient vector counterpart (rLCMV/ΔNP). NP but not GP is a minimal trans-acting factor for viral transcription and genome replication. We found that, unlike rLCMV/ΔGP, rLCMV/ΔNP failed to elicit detectable CD8(+) T cell responses unless NP was trans complemented in a transgen...
3 CitationsSource
#1Nicolas Fasnacht (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 3
#2Hsin-Ying Huang (UNIL: University of Lausanne)H-Index: 5
Last. Freddy Radtke (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 75
view all 14 authors...
Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell–cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-mediated lineage specification and immune response. Genetic ablation of the Notch ligand Delta-like (DL)1 i...
70 CitationsSource
#1Weldy V. Bonilla (University of Geneva)H-Index: 7
#2Anja Fröhlich (Charité)H-Index: 7
Last. Daniel D. Pinschewer (University of Geneva)H-Index: 33
view all 16 authors...
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal exp...
228 CitationsSource