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Marco Quarta
Stanford University
CalsequestrinSkeletal muscleStem cellBiologyCell biology
29Publications
12H-index
725Citations
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Publications 38
Newest
#1Jamie O. Brett (Stanford University)H-Index: 6
#2Marina Arjona (Stanford University)H-Index: 1
Last. Daniel I. Benjamin (Stanford University)H-Index: 1
view all 15 authors...
Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient in older organisms. Despite this functional decline, old MuSCs are amenable to rejuvenation through strategies that improve the systemic milieu, such as heterochronic parabiosis. One such strategy, exercise, has long been appreciated for its benefits on healthspan, but its effects on aged stem-cell function in the context of...
1 CitationsSource
#1Tapash Jay Sarkar (Stanford University)
#2Marco QuartaH-Index: 12
Last. Lei S. Qi (Stanford University)H-Index: 30
view all 13 authors...
Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis. Nuclear reprogramming to pluripotency can revert both the age and the identity of any cell to that of an embryonic cell. Recent evidence shows that transient repr...
1 CitationsSource
#1Vivianne L. Tawfik (Stanford University)H-Index: 16
#2Marco Quarta (Stanford University)H-Index: 12
Last. J. David Clark (Stanford University)H-Index: 52
view all 9 authors...
KEY POINTS: Our tibial fracture orthopaedic injury model in mice recapitulates the major manifestations of complex trauma, including nociceptive sensitization, bone fracture, muscle fibrosis and muscle fibre loss. Delayed exercise after complex orthopaedic trauma results in decreased muscle fibrosis and improved pain Losartan, an angiotensin-receptor blocker with anti-fibrotic abilities, recapitulates the effect of exercise on post-injury recovery and may provide an enhanced recovery option for ...
1 CitationsSource
#1Antoine de Morrée (Stanford University)H-Index: 11
#2Julian D. D. Klein (Stanford University)H-Index: 1
Last. Thomas A. Rando (Stanford University)H-Index: 70
view all 10 authors...
Adult stem cells are essential for tissue homeostasis. In skeletal muscle, muscle stem cells (MuSCs) reside in a quiescent state, but little is known about the mechanisms that control homeostatic turnover. Here we show that, in mice, the variation in MuSC activation rate among different muscles (for example, limb versus diaphragm muscles) is determined by the levels of the transcription factor Pax3. We further show that Pax3 levels are controlled by alternative polyadenylation of its transcript,...
3 CitationsSource
#1Vivianne L. Tawfik (Stanford University)H-Index: 16
#2Marco Quarta (Stanford University)H-Index: 12
Last. J. David Clark (Stanford University)H-Index: 52
view all 9 authors...
Chronic pain and disability after limb injury are major public health problems. One key obstacle to addressing these adverse outcomes is that we do not know when exercise should be initiated or whether the beneficial effects of exercise can be reproduced using pharmacological tools. In these studies, we developed and used a murine model of orthopaedic trauma combining tibia fracture and pin fixation with tibialis anterior muscle damage. Behavioral measures included mechanical nociceptive thresho...
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#1Karina H. Nakayama (Cardiovascular Institute of the South)H-Index: 10
#2Marco Quarta (Stanford University)H-Index: 12
Last. Ngan F. Huang (Cardiovascular Institute of the South)H-Index: 31
view all 11 authors...
Traumatic skeletal muscle injuries cause irreversible tissue damage and impaired revascularization. Engineered muscle is promising for enhancing tissue revascularization and regeneration in injured muscle. Here we fabricated engineered skeletal muscle composed of myotubes interspersed with vascular endothelial cells using spatially patterned scaffolds that induce aligned cellular organization, and then assessed their therapeutic benefit for treatment of murine volumetric muscle loss. Murine skel...
1 CitationsSource
#1Tapash Jay Sarkar (Stanford University)
#2Marco QuartaH-Index: 12
Last. Vittorio Sebastiano (Stanford University)H-Index: 22
view all 12 authors...
Summary Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels1-3. At the chromatin level, aging is associated with the progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis3. The technology of nuclear reprogramming to pluripotency, through over-expression of a small number of transcription factors, can revert both th...
Source
#1Derrick C. Wan (Stanford University)H-Index: 29
#2Stefanie L. Morgan (Stanford University)H-Index: 5
Last. Kevin C. Wang (Stanford University)H-Index: 18
view all 29 authors...
Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify...
3 CitationsSource
#1Marco QuartaH-Index: 12
#2Melinda J. Cromie Lear (Stanford University)H-Index: 1
Last. Thomas A. Rando (Stanford University)H-Index: 70
view all 6 authors...
Despite the regenerative capacity of muscle, tissue volume is not restored after volumetric muscle loss (VML), perhaps due to a loss-of-structural extracellular matrix. We recently demonstrated the structural and functional restoration of muscle tissue in a mouse model of VML using an engineered “bioconstruct,” comprising an extracellular matrix scaffold (decellularized muscle), muscle stem cells (MuSCs), and muscle-resident cells (MRCs). To test the ability of the cell-based bioconstruct to res...
2 CitationsSource
#1Karina H. Nakayama (Cardiovascular Institute of the South)H-Index: 10
#2Cynthia AlcazarH-Index: 3
Last. Ngan F. Huang (Cardiovascular Institute of the South)H-Index: 31
view all 9 authors...
Muscle regeneration can be permanently impaired by traumatic injuries, despite the high regenerative capacity of skeletal muscle. Implantation of engineered biomimetic scaffolds to the site of muscle ablation may serve as an attractive off-the-shelf therapeutic approach. The objective of the study was to histologically assess the therapeutic benefit of a three-dimensional spatially patterned collagen scaffold, in conjunction with rehabilitative exercise, for treatment of volumetric muscle loss. ...
5 CitationsSource
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