Match!
D. Wade Clapp
Indiana University – Purdue University Indianapolis
147Publications
36H-index
4,974Citations
Publications 145
Newest
#1Scott R. Plotkin (Harvard University)H-Index: 39
#2Dan G. Duda (Harvard University)H-Index: 62
Last.Matthias A. Karajannis (NYU: New York University)H-Index: 28
view all 16 authors...
PURPOSEBevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing in approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and progressive vestibular schwannomas (...
Source
Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare soft tissue sarcoma that can arise from patients with NF1 (neurofibromatosis type 1). These patients are at a much greater risk of developing MPNST than the general population (10% vs. 0.01%, respectively). Existing chemotherapeutic and targeted agents have thus far not been successful in MPNST treatment, with a 5-year patient survival rate of just 35%-50%. Recent research implicates Signal Transducer and Activator of Transcription-3 (STA...
Source
#1Smita Bhatia (UAB: University of Alabama at Birmingham)H-Index: 66
#2Yanjun Chen (UAB: University of Alabama at Birmingham)H-Index: 7
Last.Michael Fisher (Children's Hospital of Philadelphia)H-Index: 48
view all 23 authors...
PURPOSEFundamental gaps in knowledge regarding the risk of subsequent neoplasms (SNs) in children with pathogenic neurofibromatosis type 1 (NF1) variants exposed to radiation and/or alkylator chemo...
Source
Source
#1Steven D. Rhodes (IU: Indiana University)H-Index: 9
#2Yongzheng He (IU: Indiana University)H-Index: 11
Last.D. Wade Clapp (IU: Indiana University)H-Index: 36
view all 14 authors...
1 CitationsSource
#1Ren-Yuan Bai (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 13
#2Dominic Esposito (Leidos)H-Index: 23
Last.Verena Staedtke (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 13
view all 7 authors...
Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional neurofibromin 1 (NF1) protein resulting from genetic alterations. A major function of NF1 is suppressing Ras activities, which is conveyed by an intrinsic GTPase-activating protein-related domain (GRD). In this study, we explored the feasibility of restoring Ras GTPase via exogenous expression of various GRD constructs, via gene delivery using a panel...
Source
#1Jeffrey R Gehlhausen (IU: Indiana University)H-Index: 1
#2Eric T. Hawley (IU: Indiana University)H-Index: 1
Last.Su-Jung Park (IU: Indiana University)H-Index: 15
view all 24 authors...
1 CitationsSource
#1Abbi Smith (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
#2Waylan K. Bessler (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
Last.D. Wade Clapp (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 36
view all 11 authors...
Source
#1Steven P. Angus (UNC: University of North Carolina at Chapel Hill)H-Index: 17
#2Janet L. Oblinger (OSU: Ohio State University)H-Index: 9
Last.Gary Johnson (UNC: University of North Carolina at Chapel Hill)H-Index: 1
view all 31 authors...
2 CitationsSource
#1Chung Ping LiaoH-Index: 10
#2Reid C. Booker (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last.Lu Q. LeH-Index: 15
view all 9 authors...
7 CitationsSource
12345678910