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Theresa Mottes
University of Cincinnati Academic Health Center
Intensive care medicineKidney diseaseRenal replacement therapyAcute kidney injuryMedicine
18Publications
12H-index
971Citations
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Publications 17
Newest
#1Stuart L. Goldstein (University of Cincinnati Academic Health Center)H-Index: 55
#2Devesh Dahale (University of Cincinnati Academic Health Center)H-Index: 3
Last. Kathleen E. Walsh (Cincinnati Children's Hospital Medical Center)H-Index: 17
view all 32 authors...
ABSTRACT Nephrotoxic medication (NTMx) exposure is a common cause of acute kidney injury (AKI) in hospitalized children. The Nephrotoxic Injury Negated by Just-in time Action (NINJA) program decreased NTMx associated AKI (NTMx-AKI) by 62% at one center. To further test the program, we incorporated NINJA across nine centers with the goal of reducing NTMx exposure and, consequently, AKI rates across these centers. NINJA screens all non-critically ill hospitalized patients for high NTMx exposure (o...
3 CitationsSource
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#1David T. SelewskiH-Index: 23
#2Stuart L. Goldstein (Cincinnati Children's Hospital Medical Center)H-Index: 55
Last. H. David HumesH-Index: 31
view all 7 authors...
1 CitationsSource
#1Maya Sterling (MUHC: McGill University Health Centre)H-Index: 1
#2Zubaida Al-Ismaili (MUHC: McGill University Health Centre)H-Index: 4
Last. Michael Zappitelli (MUHC: McGill University Health Centre)H-Index: 35
view all 15 authors...
Background Cisplatin (Cis), carboplatin (Carb), and ifosfamide (Ifos) are common nephrotoxic chemotherapies. Biomarkers of tubular injury may allow for early acute kidney injury (AKI) diagnosis. Procedure We performed a two-center (Canada, United States) pilot study to prospectively measure serum creatinine (SCr), urine neutrophil gelatinase-associated lipocalin (NGAL), and interleukin-18 (IL-18) in children receiving Cis/Carb (27 episodes), Ifos (30 episodes), and in 15 hospitalized, nonchemoth...
6 CitationsSource
#1Lorraine Lau (MUHC: McGill University Health Centre)H-Index: 1
#2Zubaida Al-Ismaili (MUHC: McGill University Health Centre)H-Index: 4
Last. Michael Zappitelli (MUHC: McGill University Health Centre)H-Index: 35
view all 12 authors...
Background Serum cystatin C (CysC) is a more accurate glomerular filtration rate marker than serum creatinine (SCr) and may rise more quickly with acute kidney injury (AKI).
4 CitationsSource
#1Stuart L. Goldstein (Cincinnati Children's Hospital Medical Center)H-Index: 55
#2Theresa Mottes (Cincinnati Children's Hospital Medical Center)H-Index: 12
Last. Eric S. Kirkendall (Cincinnati Children's Hospital Medical Center)H-Index: 14
view all 7 authors...
Exposure to nephrotoxic medication is among the most common causes of acute kidney injury (AKI) in hospitalized patients. Here we conducted a prospective quality improvement project implementing a systematic Electronic Health Record screening and decision support process (trigger) in our quaternary pediatric inpatient hospital. Eligible patients were noncritically ill hospitalized children receiving an intravenous aminoglycoside for more than 3 days or more than 3 nephrotoxins simultaneously (ex...
48 CitationsSource
#1Shina Menon (Cincinnati Children's Hospital Medical Center)H-Index: 4
#2Stuart L. Goldstein (Cincinnati Children's Hospital Medical Center)H-Index: 55
Last. Rajit K. Basu (Cincinnati Children's Hospital Medical Center)H-Index: 18
view all 9 authors...
The inconsistent ability of novel biomarkers to predict acute kidney injury (AKI) across heterogeneous patients and illnesses limits integration into routine practice. We previously retrospectively validated the ability of the renal angina index (RAI) to risk-stratify patients and provide context for confirmatory serum biomarker testing for the prediction of severe AKI.We conducted this first prospective study of renal angina to determine whether the RAI on the day of admission (Day0) risk-strat...
31 CitationsSource
#1Rajit K. BasuH-Index: 18
#2Ahmad KaddourahH-Index: 7
Last. Stuart L. GoldsteinH-Index: 55
view all 10 authors...
Background: Acute kidney injury (AKI) is associated with poor outcomes in critically ill children. Recent international consensus panels recommend standardized classification systems to improve the precision of AKI diagnosis, but there is a paucity of data to enable this refinement, particularly in pediatric critical care. Methods/Design: This is a prospective observational study. We anticipate collecting data from more than 5500 critically ill children admitted to 32 pediatric intensive care un...
3 CitationsSource
#1Rajit K. Basu (Cincinnati Children's Hospital Medical Center)H-Index: 18
#2Ahmad Kaddourah (Cincinnati Children's Hospital Medical Center)H-Index: 7
Last. Stuart L. Goldstein (Cincinnati Children's Hospital Medical Center)H-Index: 55
view all 8 authors...
Background Acute kidney injury (AKI) is associated with poor outcome in critically ill children. While data extracted from retrospective study of pediatric populations demonstrate a high incidence of AKI, the literature lacks focused and comprehensive multicenter studies describing AKI risk factors, epidemiology, and outcome. Additionally, very few pediatric studies have examined novel urinary biomarkers outside of the cardiopulmonary bypass population.
52 CitationsSource
#1Neal B. Blatt (UM: University of Michigan)H-Index: 17
#2Sushant Srinivasan (UW: University of Wisconsin-Madison)H-Index: 2
Last. Thomas P. Shanley (UM: University of Michigan)H-Index: 55
view all 5 authors...
Because of its multi-organ involvement, the syndrome of sepsis provides clinical challenges to a wide variety of health care providers. While multi-organ dysfunction triggered by sepsis requires general supportive critical care provided by intensivists, the impact of sepsis on renal function and the ability of renal replacement therapies to modulate its biologic consequences provide a significant opportunity for pediatric nephrologists and related care providers to impact outcomes. In this revie...
10 CitationsSource
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