Match!
Xiaofeng Zheng
Peking University
Molecular biologyBiochemistryRNABiologyCell biology
74Publications
19H-index
1,167Citations
What is this?
Publications 74
Newest
#1Yongfeng Yang (PKU: Peking University)H-Index: 2
#2Chuanzhen Yang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 8 authors...
The DNA damage response (DDR) is essential for maintaining genome integrity. Mounting evidence reveals that protein modifications play vital roles in the DDR. Here, we show that USP38 is involved in the DDR by regulating the activity of HDAC1. In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63-linked ubiquitin chain promoting the deacetylase activity of HDAC1. As a result, HDAC1 was able to deacetylate H3K56. USP38 deletion resulted in persistent focal accumu...
Source
#1Weicheng Zang (PKU: Peking University)H-Index: 2
#2Chuanzhen Yang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 5 authors...
The translesion synthesis (TLS) pathway is a double-edged sword in terms of genome integrity. Deficiency in TLS leads to generation of DNA double strand break (DSB) during replication stress, while excessive activation of the TLS pathway increases the risk of point mutation. Here we demonstrate that HSCARG, a cellular redox sensor, directly interacts with the key protein PCNA in the TLS pathway. HSCARG enhances the interaction between PCNA and the deubiquitinase complex USP1/UAF1 and inhibits th...
Source
#1Ruidan Xu (PKU: Peking University)H-Index: 1
#2Shuyu Yu (PKU: Peking University)
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 13 authors...
Acute myeloid leukemia (AML) is a genetically heterogeneous malignant disorder of the hematopoietic system, characterized by the accumulation of DNA-damaged immature myeloid precursors. Here, we find that hCINAP is involved in the repair of double-stranded DNA breaks (DSB) and that its expression correlates with AML prognosis. Following DSB, hCINAP is recruited to damage sites where it promotes SENP3-dependent deSUMOylation of NPM1. This in turn results in the dissociation of RAP80 from the dama...
Source
#1Chuanzhen Yang (PKU: Peking University)H-Index: 2
#2Weicheng Zang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 6 authors...
2 CitationsSource
#1Junhong Guan (PKU: Peking University)H-Index: 3
#2Xiaofeng Zheng (PKU: Peking University)H-Index: 19
Abstract Genome integrity is important for cell growth, development and proliferation. The E3 ligase RAD18 plays a vital role in the DNA damage response (DDR) to maintain genome integrity. Recent studies reveal that RAD18 has non-ubiquitinated and mono-ubiquitinated form in normal cells. However, whether RAD18 undergoes other post-translational modification remains to be investigated. Here we show that RAD18 is a target of NEDD8, an ubiquitin-like protein. In response to hydrogen peroxide (H2O2)...
Source
#1Si LiuH-Index: 1
#2Lingyi XuH-Index: 1
Last. Sheng YeH-Index: 1
view all 11 authors...
Source
#1Liting Zhang (Soochow University (Suzhou))H-Index: 4
#2Jin Liu (Soochow University (Suzhou))H-Index: 4
Last. Hui Zheng (Soochow University (Suzhou))H-Index: 10
view all 12 authors...
During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical to induce the production of type I interferons (IFNs) and proinflammatory cytokines. While activation of the MAVS/TRAF3/TRAF6 signalosome is well studied, the negative regulation of the signalosome remains largely unknown. Here we report that RNA viruses specifically promote the deubiquitinase OTUD1 expression by NF-κB-dependent mechanisms at the early stage of viral infection. ...
7 CitationsSource
#2Chelsea SeverinH-Index: 1
Last. Ming LuoH-Index: 41
view all 5 authors...
X-ray crystallographic structural determinations of the PB2 cap binding domain (PB2cap) have improved the conformational characterization of the RNA-dependent RNA polymerase machinery (PA, PB2, and PB1) of the influenza virus. Geometrically, the catalytic PB1 subunit resembles the palm of a human hand. PA lies near the thumb region, and PB2 lies near the finger region. PB2 binds the cap moiety in the pre-mRNA of the host cell, while the endonuclease of PA cleaves the pre-mRNA 10–13 nucleotides d...
1 CitationsSource
#1Chuanzhen Yang (PKU: Peking University)H-Index: 2
#2Weicheng Zang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 11 authors...
A competent DNA damage response (DDR) helps prevent cancer, but once cancer has arisen DDR can blunt the efficacy of chemotherapy and radiotherapy which cause lethal DNA breakage in cancer cells. Thus, blocking DDR may improve the efficacy of these modalities. Here we report a new DDR mechanism that interfaces with inflammatory signaling and might be blocked to improve anticancer outcomes. Specifically, we report that the ubiquitin-editing enzyme A20 binds and inhibits the E3 ubiquitin ligase RN...
5 CitationsSource
#1Junhong Guan (PKU: Peking University)H-Index: 3
#2Shuyu Yu (PKU: Peking University)H-Index: 1
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 3 authors...
NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8 (NEDD8) and the roles of NEDDylation involved in the DNA damage response (DDR) are largely unknown. Translesion synthesis (TLS) is a damage-tolerance mechanism, in which RAD18/RAD6-mediated monoubiquitinated proliferating cell nuclear antigen (PCNA) promotes recruitment of polymerase η (polη) to bypass lesions. Here we identify PCNA as a subst...
4 CitationsSource
12345678