Elizabeth Offord-Cavin
EndocrinologyHesperidinActive ingredientCalciumMedicine
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Publications 13
Context: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. Objective: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. Design: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healt...
7 CitationsSource
#1Berdine R. Martin (Purdue University)H-Index: 35
#2Linda D. McCabe (Purdue University)H-Index: 18
Last. Connie M. Weaver (Purdue University)H-Index: 64
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Hesperidin is a flavonoid derived from citrus fruits that has been shown to improve bone mass and strength in pre-clinical studies in rodents. This double blind randomized order cross-over study wa...
1 Citations
#1H. BachmannH-Index: 2
#2Elizabeth Offord-Cavin (Nestlé)H-Index: 4
Last. Georg A. Mathis (Winterthur Museum, Garden and Library)H-Index: 2
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Abstract Vitamin D requires two metabolic steps to become biologically active. In a first step 25-hydroxyvitamin D 3 is formed, which acts as storage form. After a tightly controlled step in kidney the active metabolite 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) is formed. Because kidney is the relevant metabolic organ for this conversion, 1,25(OH) 2 D 3 needs to be supplemented in patients with kidney malfunction or kidney failure. Synthetic 1,25(OH) 2 D 3 (calcitriol) has been available as a ...
6 CitationsSource
#1Winnie Siew Swee Chee (International Medical University)H-Index: 8
#2P. N. Chong (UKM: National University of Malaysia)H-Index: 1
Last. Elizabeth Offord-Cavin (Nestlé)H-Index: 4
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Bone health status was investigated in 178 free-living Chinese post-menopausal women in Kuala Lumpur. Body mass index (BMI), body composition (using whole body DXA), calcium intake and serum 25-OH vitamin D status were measured along with biochemical markers of bone turnover, that is, pro-collagen Type 1 N-terminal peptide (P1NP), osteocalcin (OC) and C-telopeptide s cross link of Type 1 collagen (CTX- β). Bone mineral density (BMD) was measured using DXA (Hologic, USA) at the lumbar spine, femo...
5 Citations
#1Inge Lise F. Nielsen (Nestlé)H-Index: 9
#2W. S. S. Chee (Nestlé)H-Index: 4
Last. Gary Williamson (Nestlé)H-Index: 92
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Hesperidin is the predominant polyphenol consumed from citrus fruits and juices. However, hesperidin is proposed to have limited bioavailability due to the rutinoside moiety attached to the flavonoid. The aim of this study was to demonstrate in human subjects that the removal of the rhamnose group to yield the corresponding flavonoid glucoside (i.e., hesperetin-7-glucoside) will improve the bioavailability of the aglycone hesperetin. Healthy volunteers (n = 16) completed the double-blind, random...
190 CitationsSource
#1Myriam RichelleH-Index: 18
Last. Angus M. MoodycliffeH-Index: 5
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Composition for oral administration, which contains, as active ingredient, at least one flavanone compound, which is hesperidin, for use in prevention and / or treatment of skin diseases.
#1Didier CourtoisH-Index: 15
#2Ermanno FedericiH-Index: 16
Last. Elizabeth Offord-CavinH-Index: 4
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A food composition intended for the prevention, alleviation and / or treatment of bone disorders or maintenance of bone health in humans and pets, which comprises, as active ingredient, an effective amount of at least a plant or plant extract of Amelanchier.
#2Ermanno FedericiH-Index: 16
Last. Didier CourtoisH-Index: 15
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#2Ermanno FedericiH-Index: 16
Last. Didier CourtoisH-Index: 15
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#1Didier CourtoisH-Index: 15
#2Ermanno FedericiH-Index: 16
Last. Elizabeth Offord-CavinH-Index: 4
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Composicion que contiene una planta o extracto vegetal que contiene compuestos fitoquimicos que presentan la capacidad de estimular la proteina morfogenetica osea, en la que la planta o extracto vegetal es Rosmarinus, destinada a la prevencion, alivio y/o tratamiento de trastornos oseos y al mantenimiento de la salud osea en seres humanos o animales de compania.