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Alan J. Grodzinsky
Massachusetts Institute of Technology
411Publications
78H-index
23.8kCitations
Publications 401
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#1Ian J. Wallace (Harvard University)H-Index: 13
Last.Daniel E. Lieberman (Harvard University)H-Index: 4
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Summary Objective To investigate whether and how a sedentary lifestyle contributes to knee osteoarthritis (OA) incidence and severity. Design An experiment was conducted using Hartley guinea pigs, an established idiopathic knee OA model. To simulate a sedentary lifestyle, growing animals (n = 18) were housed for 22 weeks in small cages that restricted their mobility, while another group of animals (n = 17) received daily treadmill exercise to simulate moderate physical activity. After the experi...
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#1Brianne K. Connizzo (MIT: Massachusetts Institute of Technology)H-Index: 13
#2Alan J. Grodzinsky (MIT: Massachusetts Institute of Technology)H-Index: 78
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#1H LiebesnyPaul (MIT: Massachusetts Institute of Technology)H-Index: 1
#2MroszczykKeri (MIT: Massachusetts Institute of Technology)H-Index: 1
Last.Alan J. Grodzinsky (MIT: Massachusetts Institute of Technology)H-Index: 78
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Focal cartilage defects caused by joint injury have a limited capacity to self-repair and, if left untreated, can lead to the early onset of osteoarthritis. The current standard of care, microfract...
1 CitationsSource
#1Brianne K. Connizzo (MIT: Massachusetts Institute of Technology)H-Index: 13
#2Judith M. Piet (NU: Northeastern University)H-Index: 1
Last.Alan J. GrodzinskyH-Index: 78
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ABSTRACTPurpose of the Study: The incidence of tendon injuries increases dramatically with age, which presents a major clinical burden. While previous studies have sought to identify age-related ch...
1 CitationsSource
#1Giorgio SeanoH-Index: 1
#2Hadi T. NiaH-Index: 1
Last.Rakesh JainH-Index: 1
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#1Eliot H. FrankH-Index: 28
#2Han-Hwa HungH-Index: 12
Last.Alan J. GrodzinskyH-Index: 78
view all 6 authors...
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#1Giorgio Seano (Curie Institute)H-Index: 18
#2Hadi Tavakoli Nia (Harvard University)H-Index: 13
Last.Rakesh K. Jain (Harvard University)H-Index: 170
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The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on brain tissue are unknown. Here, via imaging studies in patients and by using mouse models of human brain tumours, we show that a subgroup of primary and metastatic brain tumours, classified as nodular on the basis of their growth pattern, exert solid stress on the surrounding brain tissue, ...
11 CitationsSource
#1Jonathan B. Sellon (MIT: Massachusetts Institute of Technology)H-Index: 5
#2Mojtaba Azadi (MIT: Massachusetts Institute of Technology)H-Index: 7
Last.Dennis M. Freeman (MIT: Massachusetts Institute of Technology)H-Index: 19
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