Alan J. Grodzinsky
Massachusetts Institute of Technology
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Publications 390
#1Atte S. A. Eskelinen (University of Eastern Finland)H-Index: 1
#2Petri Tanska (University of Eastern Finland)H-Index: 9
Last. Rami K. Korhonen (University of Eastern Finland)H-Index: 35
view all 7 authors...
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source of tissue fixed charge density (FCD). In order to predict the simultaneous effect of these degrading mechanisms on FCD content, a computational model...
#1R. Black (MIT: Massachusetts Institute of Technology)
#2Yang Wang (MIT: Massachusetts Institute of Technology)H-Index: 9
Last. Patrik Önnerfjord (Lund University)H-Index: 28
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#1Brianne K. Connizzo (MIT: Massachusetts Institute of Technology)H-Index: 15
#2Alan J. Grodzinsky (MIT: Massachusetts Institute of Technology)H-Index: 79
: Secondary joint damage is the process by which a single injury can lead to detrimental changes in adjacent tissue structures, typically through the spread of inflammatory responses. We recently developed an in vitro model of secondary joint damage using a murine rotator cuff explant system, in which injuries to muscle and bone cause massive cell death in otherwise uninjured tendon. The purpose of the present study was to test the ability cytokine-targeted and broad-spectrum therapeutics to pre...
#1Brianne K. Connizzo (MIT: Massachusetts Institute of Technology)H-Index: 15
#2Judith M. Piet (NU: Northeastern University)H-Index: 1
Last. Alan J. GrodzinskyH-Index: 79
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ABSTRACTPurpose of the Study: The incidence of tendon injuries increases dramatically with age, which presents a major clinical burden. While previous studies have sought to identify age-related ch...
1 CitationsSource
While glucocorticoids have been used for over 50 years to treat rheumatoid and osteoarthritis pain, the prescription of glucocorticoids remains controversial because of potentially harmful side effects at the molecular, cellular and tissue levels. One member of the glucocorticoid family, dexamethasone (DEX) has recently been demonstrated to rescue cartilage matrix loss and chondrocyte viability in animal studies and cartilage explant models of tissue injury and post-traumatic osteoarthritis, sug...
3 CitationsSource
#1Ian J. Wallace (Harvard University)H-Index: 15
Last. Daniel E. Lieberman (Harvard University)H-Index: 6
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Summary Objective To investigate whether and how a sedentary lifestyle contributes to knee osteoarthritis (OA) incidence and severity. Design An experiment was conducted using Hartley guinea pigs, an established idiopathic knee OA model. To simulate a sedentary lifestyle, growing animals (n = 18) were housed for 22 weeks in small cages that restricted their mobility, while another group of animals (n = 17) received daily treadmill exercise to simulate moderate physical activity. After the experi...
#1Gustavo Zanotto (CSU: Colorado State University)H-Index: 1
#2Paul H. Liebesny (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. David D. Frisbie (CSU: Colorado State University)H-Index: 33
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: The objective of this study was to improve cartilage repair and integration using self-assembling KLD hydrogel functionalized with platelet-derived growth factor-BB and heparin-binding insulin-like growth factor-1 with associated enzymatic trypsin pre-treatment of the native cartilage. Bilateral osteochondral defects were created at the central portion of the femoral trochlear groove of 48 skeletally mature, white New Zealand rabbits. One limb received a randomly assigned treatment and the con...
1 CitationsSource
#1H LiebesnyPaul (MIT: Massachusetts Institute of Technology)H-Index: 1
#1Paul H. Liebesny (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Alan J. Grodzinsky (MIT: Massachusetts Institute of Technology)H-Index: 79
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Focal cartilage defects caused by joint injury have a limited capacity to self-repair and, if left untreated, can lead to the early onset of osteoarthritis. The current standard of care, microfract...
3 CitationsSource
#1Giorgio SeanoH-Index: 1
#1Giorgio SeanoH-Index: 21
Last. Rakesh JainH-Index: 1
view all 23 authors...
#1Eliot H. FrankH-Index: 29
#2Han-Hwa HungH-Index: 10
Last. Alan J. GrodzinskyH-Index: 79
view all 6 authors...