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Meina Neumann-Schaal
Braunschweig University of Technology
13Publications
5H-index
101Citations
Publications 13
Newest
#1Anna M. Vetter (Braunschweig University of Technology)
#2Julia Helmecke (Braunschweig University of Technology)
Last.Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 5
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Microorganisms are well adapted to their habitat but are partially sensitive to toxic metabolites or abiotic compounds secreted by other organisms or chemically formed under the respective environmental conditions. Thermoacidophiles are challenged by pyroglutamate, a lactam that is spontaneously formed by cyclization of glutamate under aerobic thermoacidophilic conditions. It is known that growth of the thermoacidophilic crenarchaeon Saccharolobus solfataricus (formerly Sulfolobus solfataricus) ...
Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is directly related to its unique metabolism, using multiple Stickland-type amino acid fermentation reactions coupled to Rnf complex-mediated sodium/proton gradient formation for ATP generation. Major pathways utilize phenylalanine, leucine, glycine and proline with the formation of 3-phenylproprionate, isocaproate, butyr...
In natural environments microorganisms encounter extreme changes in temperature, pH, osmolarities and nutrient availability. The stress response of many bacterial species has been described in detail, however, knowledge in Archaea is limited. Here, we describe the cellular response triggered by nutrient limitation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. We measured changes in gene transcription and protein abundance upon nutrient depletion up to 4 h after initiation of n...
#1Isabel Bernal (Otto-von-Guericke University Magdeburg)H-Index: 1
#2Julia Danielle Hofmann (Braunschweig University of Technology)H-Index: 2
Last.Lothar JänschH-Index: 35
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Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized. Here we identified for the first time that both, non-toxigenic strains as well as the hypervirulent ribotypes RT027 and RT023 of Clostridioides difficile (formerly Clostridium difficile), induced an effector phenotype in mucosal-associated invariant T (MAIT) cells. MAIT cells can direct...
#1Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 5
#2Nicole G. Metzendorf (University of Greifswald)H-Index: 1
Last.Susanne Sievers (University of Greifswald)H-Index: 7
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Abstract Clostridioides difficile is the major pathogen causing diarrhea following antibiotic treatment. It is considered to be a strictly anaerobic bacterium, however, previous studies have shown a certain and strain-dependent oxygen tolerance. In this study, the model strain C. difficile 630Δ erm was shifted to micro-aerobiosis and was found to stay growing to the same extent as anaerobically growing cells with only few changes in the metabolite pattern. However, an extensive change in gene ex...
#1Elisabeth Härtig (Braunschweig University of Technology)H-Index: 17
#2Claudia Frädrich (Braunschweig University of Technology)H-Index: 2
Last.Dieter Jahn (Braunschweig University of Technology)H-Index: 47
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#1Helge Stark (Braunschweig University of Technology)H-Index: 2
#2Jacqueline Wolf (Braunschweig University of Technology)H-Index: 2
Last.Dietmar Schomburg (Braunschweig University of Technology)H-Index: 57
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The thermoacidophilic Crenarchaeon Sulfolobus solfataricus is a model organism for archaeal adaptation to extreme environments and renowned for its ability to degrade a broad variety of substrates. It has been well characterised concerning the utilisation of numerous carbohydrates as carbon source. However, its amino acid metabolism, especially the degradation of single amino acids, is not as well understood. In this work, we performed metabolic modelling as well as metabolome, transcriptome and...
#1Sabine Eva Will (Braunschweig University of Technology)H-Index: 3
#2Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 5
Last.Dietmar Schomburg (Braunschweig University of Technology)H-Index: 57
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Phaeobacter inhibens DSM 17395, a model organism for marine Roseobacter group, was studied for its response to its own antimicrobial compound tropodithietic acid (TDA). TDA biosynthesis is encoded on the largest extrachromosomal element of P. inhibens, the 262 kb plasmid, whose curation leads to an increased growth and biomass yield. In this study, the plasmid-cured strain was compared to the wild-type strain and to transposon mutants lacking single genes of the TDA biosynthesis. The data show t...
#1Henning Dannheim (Braunschweig University of Technology)H-Index: 2
#2Sabine Eva Will (Braunschweig University of Technology)H-Index: 3
Last.Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 5
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Antibiotic associated infections with Clostridioides difficile are a severe and often lethal risk for hospitalized patients, but can also affect populations without these classical risk factors. For a rational design of therapeutical concepts, a better knowledge of the metabolism of the pathogen is crucial. Metabolic modeling can provide a simulation of quantitative growth and usage of metabolic pathways, leading to a deeper understanding of the organism. Here, we present an elaborate genome-sca...
#1Henning Dannheim (Braunschweig University of Technology)H-Index: 2
#2Thomas Riedel (Leibniz Association)H-Index: 9
Last.J. Overmann (Leibniz Association)H-Index: 46
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Purpose. We resequenced the genome of Clostridium difficile 630Δerm (DSM 28645), a model strain commonly used for the generation of insertion mutants. Methodology. The genome sequence was obtained by a combination of single-molecule real-timeand Illumina sequencing technology. Results. Detailed manual curation and comparison to the previously published genomic sequence revealed sequence differences including inverted regions and the presence of plasmid pCD630. Manual curation of our previously d...
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