Meina Neumann-Schaal
Braunschweig University of Technology
Sulfolobus solfataricusBiochemistryMetabolismBiologyMicrobiology
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Publications 18
#1Julia Helmecke (Braunschweig University of Technology)
#2Dietmar Schomburg (Braunschweig University of Technology)H-Index: 58
Last. Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 6
view all 3 authors...
Metabolic pathways are an important part of systems biology research since they illustrate complex interactions between metabolites, enzymes, and regulators. Pathway maps are drawn to elucidate metabolism or to set data in a metabolic context. We present MetaboMAPS, a web-based platform to visualize numerical data on individual metabolic pathway maps. Metabolic maps can be stored, distributed and downloaded in SVG-format. MetaboMAPS was designed for users without computational background and sup...
#1Thomas Riedel (Leibniz Association)H-Index: 10
#2Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 6
Last. Uwe Gross (GAU: University of Göttingen)H-Index: 30
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During the last decades, hypervirulent strains of Clostridioides difficile with frequent disease recurrence and increased mortality appeared. C. difficile DSM 101085 was isolated from a patient who suffered from several recurrent infections and colonizations, likely contributing to a fatal outcome. Analysis of the toxin repertoire revealed the presence of a complete binary toxin locus (CdtLoc) and an atypical PaLoc consisting of only a tcdA pseudogene and a disrupted tcdC gene sequence. The PaLo...
#1Anna M. Vetter (Braunschweig University of Technology)
#2Julia Helmecke (Braunschweig University of Technology)
Last. Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 6
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Microorganisms are well adapted to their habitat but are partially sensitive to toxic metabolites or abiotic compounds secreted by other organisms or chemically formed under the respective environmental conditions. Thermoacidophiles are challenged by pyroglutamate, a lactam that is spontaneously formed by cyclization of glutamate under aerobic thermoacidophilic conditions. It is known that growth of the thermoacidophilic crenarchaeon Saccharolobus solfataricus (formerly Sulfolobus solfataricus) ...
#1Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 6
#2Dieter Jahn (Braunschweig University of Technology)H-Index: 47
Last. Kerstin Schmidt-Hohagen (Braunschweig University of Technology)H-Index: 9
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Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is directly related to its unique metabolism, using multiple Stickland-type amino acid fermentation reactions coupled to Rnf complex-mediated sodium/proton gradient formation for ATP generation. Major pathways utilize phenylalanine, leucine, glycine and proline with the formation of 3-phenylproprionate, isocaproate, butyr...
2 CitationsSource
#1Lisa Franziska Bischof (University of Freiburg)H-Index: 2
#2M. Florencia Haurat (University of Freiburg)H-Index: 2
Last. Sonja-Verena Albers (University of Freiburg)H-Index: 44
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In natural environments microorganisms encounter extreme changes in temperature, pH, osmolarities and nutrient availability. The stress response of many bacterial species has been described in detail, however, knowledge in Archaea is limited. Here, we describe the cellular response triggered by nutrient limitation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. We measured changes in gene transcription and protein abundance upon nutrient depletion up to 4 h after initiation of n...
2 CitationsSource
#1Isabel Bernal (Otto-von-Guericke University Magdeburg)H-Index: 2
#2Julia Danielle Hofmann (Braunschweig University of Technology)H-Index: 2
Last. Lothar JänschH-Index: 35
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Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized. Here we identified for the first time that both, non-toxigenic strains as well as the hypervirulent ribotypes RT027 and RT023 of Clostridioides difficile (formerly Clostridium difficile), induced an effector phenotype in mucosal-associated invariant T (MAIT) cells. MAIT cells can direct...
2 CitationsSource
#1Elisabeth Härtig (Braunschweig University of Technology)H-Index: 16
#2Claudia Frädrich (Braunschweig University of Technology)H-Index: 2
Last. Dieter Jahn (Braunschweig University of Technology)H-Index: 47
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The LysR-type transcriptional regulator (LTTR) AlsR from Bacillus subtilis activates the transcription of the alsSD operon encoding enzymes for acetoin formation in response to the presence of acetate. The structural basis for effector binding, oligomerization, DNA binding, higher ordered complex formation, DNA bending and transcriptional control by B. subtilis AlsR was functionally characterized. The binding of two molecules of acetate per molecule AlsR was determined. Acetate-dependent transcr...
1 CitationsSource
#1Julia D. Hofmann (Braunschweig University of Technology)H-Index: 3
#2Andreas Otto (University of Greifswald)H-Index: 27
Last. Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 3
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The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium difficile) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy. Major virulence factors of the bacterium are the two large clostridial toxins TcdA and TcdB. The production of both toxins was found strongly connected to the metabolism and the nutritional status of the growth environment. Here, we systematically investigated the changes of the gene regulatory, proteo...
5 CitationsSource
#1Meina Neumann-Schaal (Braunschweig University of Technology)H-Index: 6
#2Nicole G. Metzendorf (University of Greifswald)H-Index: 1
Last. Susanne Sievers (University of Greifswald)H-Index: 7
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Abstract Clostridioides difficile is the major pathogen causing diarrhea following antibiotic treatment. It is considered to be a strictly anaerobic bacterium, however, previous studies have shown a certain and strain-dependent oxygen tolerance. In this study, the model strain C. difficile 630Δerm was shifted to micro-aerobiosis and was found to stay growing to the same extent as anaerobically growing cells with only few changes in the metabolite pattern. However, an extensive change in gene exp...
1 CitationsSource
#1Matthias Steglich (Leibniz Association)H-Index: 8
#2Julia D. Hofmann (Braunschweig University of Technology)H-Index: 3
Last. Ulrich Nübel (BRICS)H-Index: 1
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We report the frequent, convergent loss of two genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. This specific genomic deletion was strongly associated with the reduced uptake of tyrosine and phenylalanine and production of derived Stickland fermentation products, including p-cresol, suggesting that the affected ABC transporter had been responsible for the import of...
6 CitationsSource