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Pietari Ripatti
University of Helsinki
21Publications
2H-index
26Citations
Publications 21
Newest
#1R. Tabassum (UH: University of Helsinki)H-Index: 1
#2FinnGen (UH: University of Helsinki)
Last.Samuli Ripatti (MIT: Massachusetts Institute of Technology)
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Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16...
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#1Pietari RipattiH-Index: 2
#2Joel T. Rämö (UH: University of Helsinki)H-Index: 3
Last.Samuli RipattiH-Index: 62
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Background: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). Monogenic familial hypercholesterolemia associates with higher increase in CAD risk than expected from a single LDL-C measurement, likely due to lifelong cumulative exposure to high LDL-C. It remains unclear to what extent a high polygenic load of LDL-C or TG-increasing variants associates with increased CAD risk. Methods and Results: We derived polygenic risk scores (PRS) with ~6M variants for LDL-C ...
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#1Nina J. Mars (UH: University of Helsinki)H-Index: 1
#2Jukka Koskela (UH: University of Helsinki)H-Index: 6
Last.Samuli Ripatti (UH: University of Helsinki)H-Index: 62
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ABSTRACT Background Polygenic risk scores (PRS) have shown promise in predicting susceptibility to common diseases. However, the extent to which PRS and clinical risk factors act jointly and identify high-risk individuals for early onset of disease is unknown. Methods We used large-scale biobank data (the FinnGen study; n=135,300), with up to 46 years of prospective follow-up, and the FINRISK study with standardized clinical risk factor measurements to build genome-wide PRSs with >6M variants fo...
2 CitationsSource
#2Pietari RipattiH-Index: 2
Last.Elisabeth WidenH-Index: 62
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#1R. Tabassum (UH: University of Helsinki)H-Index: 1
#2Joel T. Rämö (UH: University of Helsinki)H-Index: 3
Last.Samuli Ripatti (Broad Institute)H-Index: 62
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#1Joel T. Rämö (UH: University of Helsinki)H-Index: 3
#2Pietari Ripatti (UH: University of Helsinki)H-Index: 2
Last.Samuli Ripatti (Broad Institute)H-Index: 23
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Background We asked whether, after excluding familial hypercholesterolemia, individuals with high low‐density lipoprotein cholesterol (LDL‐C) or triacylglyceride levels and a family history of the ...
1 CitationsSource
#1Tuomo Kiiskinen (UH: University of Helsinki)H-Index: 2
#2Nina J. Mars (UH: University of Helsinki)H-Index: 1
Last.Samuli Ripatti (Broad Institute)H-Index: 62
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Objective: To develop a highly polygenic risk score (PRS) for alcohol consumption and study whether it predicts alcohol-related morbidity and all-cause mortality. Design: Biobank-based prospective cohort study. Setting: FinnGen Study (Finland). Participants: 96,499 genotyped participants from the nationwide prospective FinnGen study and 36,499 participants from prospective cohorts (Health 2000, FINRISK, Twin Cohort) with detailed baseline data and up to 25 years of follow-up time. Main outcome m...
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#1Pietari Ripatti (UH: University of Helsinki)H-Index: 2
#2Sanni Söderlund (UH: University of Helsinki)H-Index: 16
Last.Samuli Ripatti (UH: University of Helsinki)H-Index: 62
view all 13 authors...
Hyperlipidemia, particularly high LDL-C or TG, is the most important heritable risk factor for coronary artery disease (CAD). Its most severe form, monogenic familial hypercholesterolemia (FH) increases CAD risk more than expected from a single LDL-C measurement, likely due to lifelong cumulative
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Familial hyperlipidemias including but not limited to familial hypercholesterolemia (FH) are often evaluated distinctly from population-based hyperlipidemias. We asked whether this practice is warranted either by greater coronary artery disease (CAD) risk or by different detailed lipid profiles in
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#1R. TabassumH-Index: 1
#2Joel T. RämöH-Index: 1
Last.Samuli RipattiH-Index: 62
view all 27 authors...
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