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Eman M. Mantawy
Ain Shams University
10Publications
4H-index
142Citations
Publications 12
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#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Abstract Aim Liver fibrosis represents a massive global health burden with limited therapeutic options. Thus, the need for curative options is evident. Thus, this study aimed to assess the potential antifibrotic effect of honokiol in Concanavalin A (Con A) induced immunological model of liver fibrosis as well the possible underlying molecular mechanisms. Methods Male Sprague-Dawley rats were treated with either Con A (20 mg/kg, IV) and/or honokiol (10 mg/kg, orally) for 4 weeks. Hepatotoxicity i...
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#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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This study was performed to examine whether clindamycin could protect against doxorubicin (DOX)-induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for this protective effect. Male albino rats were pretreated with clindamycin once per day for 5 consecutive days at a dose of 300 mg/kg, i.p, then received a single dose of DOX (15 mg/kg; i.p) on the 5th day. DOX-induced marked renal injury as indicated by the presence of inflammatory cell infiltration, congestion, and ede...
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#1Fatma A. Mostafa (Ain Shams University)H-Index: 1
#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Abstract Benign prostatic hyperplasia (BPH) is the most widespread urological disorder among elderly men. It is influenced by several factors, among which is the prostatic renin angiotensin system (RAS). Prostatic RAS activates several signaling pathways as proliferation, inflammation and angiogenesis that contribute to BPH development and progression. Captopril is a potent inhibitor of the angiotensin converting enzyme. Therefore, this study was performed to explore the potential protective eff...
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#1Nada Adel (Ain Shams University)
#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Abstract Hepatic iron overload is one of the causative factors for chronic liver injury and fibrosis. The present study aimed to investigate the potential antifibrotic effect of the iron chelator; deferasirox (DFX) in experimentally-induced liver fibrosis in rats. Male Sprague-Dawley rats were administered concanavalin A (Con A) and/or DFX for 6 consecutive weeks. Con A injection induced significant hepatotoxicity as was evident by the elevated transaminases activity, and decreased albumin level...
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#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Samar S. Azab (Ain Shams University)H-Index: 10
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Abstract Methotrexate (MTX) is commonly used to treat several types of cancer and autoimmune diseases. However, there is increasing concern over its organs toxicities particularly liver toxicity. Liraglutide, a glucagon like peptide-1 agonist, possesses antioxidant and anti-inflammatory features. This study aimed to explore the potential protective effect of liraglutide pre-treatment in ameliorating MTX-induced hepatotoxicity and to further investigate the underlying mechanisms. Rats received 1....
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#1Riham S. SaidH-Index: 1
#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Chemotherapeutic platinum-containing drugs are widely used to treat a variety of cancer types; however, they cause ovarian failure and infertility. The aim of this study is to investigate the molecular mechanism underlying the potential protective effect of resveratrol against cisplatin-induced ovarian damage in a rat model. Female rats were given either cisplatin (6 mg/kg, i.p., once per week for two consecutive weeks) and/or resveratrol (10 mg/kg, orally for 17 days). Follicular development, o...
1 CitationsSource
#1Eman M. Mantawy (Ain Shams University)H-Index: 4
#2Riham S. SaidH-Index: 1
Last.Amal Kamal Abdel-Aziz (Ain Shams University)H-Index: 8
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Abstract Radiotherapy is one of the most relevant treatment modalities for various types of malignancies. However, it causes premature ovarian failure (POF) and subsequent infertility in women of reproductive age; hence urging the development of effective radioprotective agents. Chrysin, a natural flavone, possesses several pharmacological activities owing to its antioxidant, anti-inflammatory and anti-apoptotic properties. Therefore, the aim of this study was to investigate the efficacy of chry...
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#1Radwa A. Eladwy (Egyptian Russian University)H-Index: 4
#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Samar S. Azab (Ain Shams University)H-Index: 10
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Abstract Background Lowbush blueberry extract (Vaccinium angustifolium) is abundant with polyphenols (such as chlorogenic acid) with high antioxidant profile. It has received great interest due to its protective role in many disorders such as heart diseases and neurological disorders. Hypothesis We hypothesized that blueberry leaf extract might have a protective effect against cardiac hypertrophy via suppressing oxidative stress, inflammation and fibrosis. Method Blueberry leaf nutraceutical ext...
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#1Eman M. Mantawy (Ain Shams University)H-Index: 4
#2Ahmed Esmat (Ain Shams University)H-Index: 13
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study aimed to investigate the potential protective effect of chrysin against DOX-induced chronic cardiotoxicity and the underlying molecular mechanisms. Male Sprague-Dawley rats were treated with either DOX (5 mg/kg...
23 CitationsSource
#1Amal Kamal Abdel-Aziz (Ain Shams University)H-Index: 8
#2Eman M. Mantawy (Ain Shams University)H-Index: 4
Last.Reham Helwa (Ain Shams University)H-Index: 5
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Abstract Chemobrain refers to a cluster of cognitive deficits which affects almost 4–75% of chemotherapy-treated cancer patients. Sunitinib, an FDA-approved multityrosine kinase inhibitor, is currently used in treating different types of tumors. Despite being regarded as targeted therapy which blunts sustained angiogenesis in cancer milieu through inhibiting vascular endothelial growth factor receptor 2 (VEGFR2) signaling, the latter has a cardinal role in cognition. Recent clinical reports warn...
13 CitationsSource
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