Frank Qian
University of Chicago
Publications 20
#1Frank Qian (Harvard University)H-Index: 7
#2Gang Liu (Harvard University)H-Index: 16
Last.Qi Sun (Harvard University)H-Index: 62
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Importance Accumulating epidemiologic evidence has suggested favorable associations between plant-based dietary patterns and risk of type 2 diabetes, although there is a lack of a quantitative summary of evidence substantiating this important association. Objective To quantitatively synthesize available prospective observational evidence on the association between plant-based dietary patterns and risk of type 2 diabetes. Data Sources A systematic search of PubMed and MEDLINE, Embase, Web of Scie...
#1Dongxu Wang (AAU: Anhui Agricultural University)H-Index: 8
#2Qiang Gao (AAU: Anhui Agricultural University)H-Index: 3
Last.Daniel GranatoH-Index: 31
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Abstract Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0....
#1Frank Qian (U of C: University of Chicago)H-Index: 7
#2Matti A. Rookus (NKI-AVL: Netherlands Cancer Institute)H-Index: 44
Last.Munaza Ahmed (GOSH: Great Ormond Street Hospital)H-Index: 2
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Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS)...
#1Dongxu Wang (AAU: Anhui Agricultural University)H-Index: 8
#2Dongxu WangH-Index: 3
Last.Yijun WangH-Index: 8
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Inflammatory liver diseases present a significant public health problem. Green tea polyphenols (GTPs) have a myriad of health benefits in animals and humans, including alleviating of hepatic inflammation; however, the underlying mechanisms are complicated and remain unclear. The current study investigated the preventive effects and mechanism of GTPs on lipopolysaccharide (LPS)-induced inflammatory liver injury in mice. The ICR mice received intragastric GTPs once per day for 7 consecutive days p...
#1Dongxu Wang (AAU: Anhui Agricultural University)H-Index: 3
#2Qiang Gao (AAU: Anhui Agricultural University)H-Index: 3
Last.Chi-Tang Ho (RU: Rutgers University)H-Index: 84
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Theanine, a unique bioactive constituent from tea (Camellia sinensis) leaves, is widely used as a functional ingredient and dietary supplement. To evaluate the anti-inflammatory and hepatoprotective effects of theanine and its molecular mechanism, the lipopolysaccharide (LPS)-induced inflammation mouse model was employed in this study. The survival rate of mice in the theanine-treated group increased significantly compared with that of LPS-only group mice. Furthermore, ICR male mice were randoml...
#1Dongxu Wang (AAU: Anhui Agricultural University)H-Index: 3
#2Min Cai (AAU: Anhui Agricultural University)
Last.Yijun Wang (AAU: Anhui Agricultural University)H-Index: 8
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Abstract Thermal stress evokes heat shock response and activates hypothalamic-pituitaryadrenal (HPA) axis. Additionally, liver injury is an important adverse effect of thermal stress. Considering the anti-stress effects of theanine, an amino acid found in tea plants, we hypothesized that theanine may protect against heat stress. Mice were administered intragastrically with theanine prior to whole body thermal exposure. Theanine prevented the heat-induced upregulation of heat shock proteins and r...
#1Shengfeng Wang (PKU: Peking University)H-Index: 3
#2Frank Qian (U of C: University of Chicago)H-Index: 7
Last.Barbara Nemesure (SUNY: State University of New York System)H-Index: 4
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Background Few studies have evaluated the performance of existing breast cancer risk prediction models among women of African ancestry. In replication studies of genetic variants, a change in direction of the risk association is a common phenomenon. Termed flip-flop, it means that a variant is risk factor in one population but protective in another, affecting the performance of risk prediction models.