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Brian J. Haas
Broad Institute
132Publications
62H-index
34.8kCitations
Publications 132
Newest
Published in bioRxiv
Livnat Jerby (Broad Institute), Cyril Neftel5
Estimated H-index: 5
(Harvard University)
+ -3 AuthorsLuisa Cironi10
Estimated H-index: 10
Synovial sarcoma is an aggressive mesenchymal neoplasm, driven by the SS18-SSX fusion, and characterized by immunogenic antigens expression and exceptionally low T cell infiltration levels. To study the cancer-immune interplay in this disease, we profiled 16,872 cells from 12 human synovial sarcoma tumors using single-cell RNA-sequencing (scRNA-Seq). Synovial sarcoma manifests antitumor immunity, high cellular plasticity and a core oncogenic program, which is predictive of low immune levels and ...
Published on May 1, 2019in Nature 43.07
Mahmoud Ghandi13
Estimated H-index: 13
(Broad Institute),
Franklin W. Huang16
Estimated H-index: 16
(Broad Institute)
+ 65 AuthorsHaoxin Li1
Estimated H-index: 1
(Broad Institute)
Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To improve our understanding of the molecular features that contribute to cancer phenotypes, including drug responses, here we have expanded the characterizations of cancer cell lines to ...
Published on Dec 1, 2018in Nature Communications 11.88
Samuel Y. Ng9
Estimated H-index: 9
(Harvard University),
Noriaki Yoshida2
Estimated H-index: 2
(Harvard University)
+ 44 AuthorsAlexandria Van Scoyk2
Estimated H-index: 2
(Harvard University)
T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are few preclinical models of TCLs, which has hampered the development of effective therapeutics. Here we establish and characterize preclinical models of TCL. We identify multiple vulnerabilities that are targetable with currently available agents (e.g., inhibitors of JAK2 or IKZF1) and demonstrate proof-of-principle for biomarker-driven the...
Published on Dec 1, 2018in Nature Communications 11.88
Nicholas D. Leigh6
Estimated H-index: 6
(Broad Institute),
Garrett S. Dunlap (Broad Institute)+ 10 AuthorsAndy I. Chen17
Estimated H-index: 17
(Brigham and Women's Hospital)
Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema have been extensively studied via histology, grafting, and bulk-tissue RNA-sequencing. However, defining the contributions of these tissues is hindered due to limited information regarding the molecular identity of the cell types in regenerating limbs. Here we report unbiased single-cell RNA-sequencing on over 25,00...
Published on Nov 1, 2018
Christophe H. Georgescu1
Estimated H-index: 1
(Broad Institute),
Abigail L. Manson6
Estimated H-index: 6
(Broad Institute)
+ 6 AuthorsAshlee M. Earl32
Estimated H-index: 32
(Broad Institute)
Accurate orthologue identification is a vital component of bacterial comparative genomic studies, but many popular sequence-similarity-based approaches do not scale well to the large numbers of genomes that are now generated routinely. Furthermore, most approaches do not take gene synteny into account, which is useful information for disentangling paralogues. Here, we present SynerClust, a user-friendly synteny-aware tool based on synergy that can process thousands of genomes. SynerClust was des...
Published on Nov 8, 2017in Mbio 6.75
Brandon T. Pfannenstiel3
Estimated H-index: 3
(UW: University of Wisconsin-Madison),
Xixi Zhao2
Estimated H-index: 2
(UW: University of Wisconsin-Madison)
+ 16 AuthorsFang Yun Lim9
Estimated H-index: 9
(UW: University of Wisconsin-Madison)
National Institute of General Medical Sciences [PO1-GM084077]; UW-Madison Food Research Institute; USDA Hatch Formula Fund [WIS01710]; Predoctoral Training Program in Genetics - National Institutes of Health [5 T32 GM007133-40]; National Institutes of Health [1R01GM112739-01]; NSF [DGE-1256259]; U.S. Forest Service, Northern Research Station
Published on Nov 1, 2017in Nature 43.07
Antonia Wallrapp2
Estimated H-index: 2
,
Samantha Riesenfeld11
Estimated H-index: 11
+ 20 AuthorsDaneyal Farouq3
Estimated H-index: 3
Published on Sep 1, 2017in Nature 43.07
Antonia Wallrapp2
Estimated H-index: 2
,
Samantha Riesenfeld11
Estimated H-index: 11
+ 20 AuthorsDaneyal Farouq3
Estimated H-index: 3
Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.
Published on Sep 1, 2017
Antonia Wallrapp2
Estimated H-index: 2
,
Samantha Riesenfeld11
Estimated H-index: 11
+ 20 AuthorsDaneyal Farouq3
Estimated H-index: 3
Published on Aug 1, 2017in Trends in Genetics 10.63
Brian J. Haas62
Estimated H-index: 62
(MIT: Massachusetts Institute of Technology),
Jessica L. Whited9
Estimated H-index: 9
(Brigham and Women's Hospital)
Humans and other mammals are limited in their natural abilities to regenerate lost body parts. By contrast, many salamanders are highly regenerative and can spontaneously replace lost limbs even as adults. Because salamander limbs are anatomically similar to human limbs, knowing how they regenerate should provide important clues for regenerative medicine. Although interest in understanding the mechanics of this process has never wavered, until recently researchers have been vexed by seemingly im...
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