Branding/Logomark minus arrow-point-to-down Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 Icon/List no author result Created with Sketch.
Loading Scinapse...
Brian J. Haas
Broad Institute
134Publications
64H-index
38.4kCitations
Publications 134
Newest
2018 in Nature CommunicationsIF: 12.35
Samuel Y. Ng9
Estimated H-index: 9
(Harvard University),
Noriaki Yoshida2
Estimated H-index: 2
(Harvard University)
+ 44 AuthorsAlexandria Van Scoyk1
Estimated H-index: 1
(Harvard University)
T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are few preclinical models of TCLs, which has hampered the development of effective therapeutics. Here we establish and characterize preclinical models of TCL. We identify multiple vulnerabilities that are targetable with currently available agents (e.g., inhibitors of JAK2 or IKZF1) and demonstrate proof-of-principle for biomarker-driven the...
2 Citations Download PDF Cite
2018
Christophe H. Georgescu (Broad Institute), Abigail L. Manson5
Estimated H-index: 5
(Broad Institute)
+ 6 AuthorsAshlee M. Earl26
Estimated H-index: 26
(Broad Institute)
Accurate orthologue identification is a vital component of bacterial comparative genomic studies, but many popular sequence-similarity-based approaches do not scale well to the large numbers of genomes that are now generated routinely. Furthermore, most approaches do not take gene synteny into account, which is useful information for disentangling paralogues. Here, we present SynerClust, a user-friendly synteny-aware tool based on synergy that can process thousands of genomes. SynerClust was des...
Source Cite
2018 in Nature CommunicationsIF: 12.35
Nicholas D. Leigh6
Estimated H-index: 6
(Broad Institute),
Garrett S. Dunlap (Broad Institute)+ 10 AuthorsAndy I. Chen3
Estimated H-index: 3
(Brigham and Women's Hospital)
Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema have been extensively studied via histology, grafting, and bulk-tissue RNA-sequencing. However, defining the contributions of these tissues is hindered due to limited information regarding the molecular identity of the cell types in regenerating limbs. Here we report unbiased single-cell RNA-sequencing on over 25,00...
Source Cite
2017
Antonia Wallrapp2
Estimated H-index: 2
,
Samantha J. Riesenfeld5
Estimated H-index: 5
+ 20 AuthorsDaneyal Farouq3
Estimated H-index: 3
Source
2017 in NatureIF: 41.58
Antonia Wallrapp2
Estimated H-index: 2
,
Samantha J. Riesenfeld5
Estimated H-index: 5
+ 20 AuthorsDaneyal Farouq3
Estimated H-index: 3
Download PDF Cite
Thiago Parente3
Estimated H-index: 3
(Oswaldo Cruz Foundation),
Daniel A. Moreira3
Estimated H-index: 3
(Oswaldo Cruz Foundation)
+ 5 AuthorsMark E. Hahn54
Estimated H-index: 54
(Woods Hole Oceanographic Institution)
Pterygoplichthys is a genus of related suckermouth armoured catfishes native to South America, which have invaded tropical and subtropical regions worldwide. Physiological features, including an augmented resistance to organic xenobiotics, may have aided their settlement in foreign habitats. The liver transcriptome of Pterygoplichthys anisitsi was sequenced and used to characterize the diversity of mRNAs potentially involved in the responses to natural and anthropogenic chemicals. In total, 66,6...
3 Citations Source Cite
2017 in Nature CommunicationsIF: 12.35
Youn-Jung Kang2
Estimated H-index: 2
,
Barbara Balter2
Estimated H-index: 2
+ 4 AuthorsCatherine T. Yan14
Estimated H-index: 14
We know that defects in DNA repair genes are associated with cancer development. Here the authors eliminate XRCC4, a non-homologous end-joining protein, and p53 in the developing brain and find that this causes glioblastoma development as a consequence of reduced PTEN function.
4 Citations Source Cite
2017 in Cell ReportsIF: 8.03
Donald M. Bryant4
Estimated H-index: 4
(Brigham and Women's Hospital),
Kimberly Johnson2
Estimated H-index: 2
(Brigham and Women's Hospital)
+ 19 AuthorsFrancis G. Davis1
Estimated H-index: 1
(Brigham and Women's Hospital)
Summary Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely sequenced genomes of axolotls have hindered the study of genes facilitating regeneration. We assembled and annotated a de novo transcriptome using RNA-sequencing profiles for a broad spectrum of tissues that is estimated to have near-complete ...
38 Citations Source Cite
2017 in Molecular EcologyIF: 6.13
Blair P. Bentley2
Estimated H-index: 2
(University of Western Australia),
Brian J. Haas64
Estimated H-index: 64
(Massachusetts Institute of Technology)
+ 1 AuthorsOliver Berry16
Estimated H-index: 16
(Commonwealth Scientific and Industrial Research Organisation)
Oviparous reptile embryos are expected to breach their critical thermal maxima if temperatures reach those predicted under current climate change models due to the lack the maternal buffering processes and parental care. Heat shock proteins (HSPs) are integral in the molecular response to thermal stress, and their expression is heritable, but the roles of other candidate families such as the heat shock factors (HSFs) have not been determined in reptiles. Here we subject embryonic sea turtles (Ca...
7 Citations Source Cite
2017 in bioRxiv
Brian J. Haas64
Estimated H-index: 64
(Broad Institute),
Alexander Dobin15
Estimated H-index: 15
(Cold Spring Harbor Laboratory)
+ 11 AuthorsNatalie Pochet1
Estimated H-index: 1
Motivation: Fusion genes created by genomic rearrangements can be potent drivers of tumorigenesis. However, accurate identification of functionally fusion genes from genomic sequencing requires whole genome sequencing, since exonic sequencing alone is often insufficient. Transcriptome sequencing provides a direct, highly effective alternative for capturing molecular evidence of expressed fusions in the precision medicine pipeline, but current methods tend to be inefficient or insufficiently accu...
10 Citations Download PDF Cite
12345678910