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Joohee Jung
Duksung Women's University
CancerMolecular biologyIn vivoCancer researchBiology
38Publications
9H-index
265Citations
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Publications 40
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#1Sungryong Oh (Duksung Women's University)H-Index: 1
#2Kiheon Choi (Duksung Women's University)
Last. Joohee Jung (Duksung Women's University)H-Index: 9
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Liver cancer shows noticeable differences in the incidence rate and mortality between genders. To investigate the estrogen effect on tumor progression in liver cancer, we developed a xenograft model using estrogen pellets. SK-Hep1 cells (human male liver carcinoma) were inoculated into male or female nude mice. Subsequently, estrogen pellets were subcutaneously implanted into these xenograft models. Interestingly, the marked adverse effect of estrogen pellets (0.5 mg/21 days) were observed in th...
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#1Yeon-su Jang (Duksung Women's University)
Last. Joohee Jung (Duksung Women's University)H-Index: 9
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#1Sun Kim (UPR-RP: UPRRP College of Natural Sciences)
#1Sun Young Kim (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
Last. Aree Moon (Duksung Women's University)H-Index: 28
view all 8 authors...
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#1Joohee Jung (Duksung Women's University)H-Index: 9
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#1Seungeun LeeH-Index: 1
#2Eunhye LeeH-Index: 2
Last. Aree MoonH-Index: 28
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Interleukin (IL)-6 plays a crucial role in the progression, invasion, and metastasis of breast cancer. Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for its aggressive metastasis. Epithelial to mesenchymal transition (EMT) is a critical process in cancer metastasis. The positive correlation between IL-6 and EMT in tumor microenvironment is reported. We found significantly upregulated IL-6 expression in MDA-MB-231 cells. A blockade of IL-6 expression decreased levels of phosp...
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#1Hyesol Lim (Duksung Women's University)H-Index: 2
#2Sun Young Kim (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
Last. Aree Moon (Duksung Women's University)H-Index: 28
view all 8 authors...
1 CitationsSource
#1Joohee Jung (Duksung Women's University)H-Index: 9
#2Do Young Song (UOU: University of Ulsan)
Last. Eun Kyung Choi (UOU: University of Ulsan)H-Index: 23
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RH1 (2, 5-diaziridinyl-3-(hydroxymethy)-6-methyl-1, 4-benzoquinone) is a bioreductive anticancer drug. The mechanism underlying its therapeutic properties has not yet been elucidated. In this study, we aimed to determine whether RH1 exerts its anticancer effect via p53-mediated apoptosis and senescence in vitro and in vivo. RH1 displayed dose-dependent biphasic effects in vitro, i.e., it induced apoptosis at higher dose and senescence at lower dose accompanied by marked activation of p53. Thus, ...
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#1Seungeun Lee (Duksung Women's University)H-Index: 1
#2Eunhye Lee (Duksung Women's University)H-Index: 2
Last. Aree Moon (Duksung Women's University)H-Index: 28
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Abstract Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that promote invasion and metastasis of cancer cells. In this study, we investigated the effect of TAMs on phenotypic conversion of non-neoplastic MCF10A human breast epithelial cells using an indirect co-culture system. Co-culture with TAMs induced epithelial-to-mesenchymal transition, invasive phenotype, and MMP-9 upregulation in MCF10A cells. Comparative proteomic analysis revealed that endoplasmic ret...
2 CitationsSource
#1Hyun Kyung LimH-Index: 4
#2Hyunsook LeeH-Index: 1
Last. Joohee JungH-Index: 9
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Predictive analytics play an important role in clinical research. An accurate predictive model can help clinicians stratify risk thereby allowing the identification of a target population which might benefit from a certain intervention. Conventionally, predictive analytics is performed using parametric modeling which comes with a number of assumptions. For example, generalized linear regression models require linearity and additivity to hold for the underlying data. However, these assumptions ma...
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