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Min-Nung Huang
Duke University
6Publications
3H-index
249Citations
Publications 6
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#1Han Kyu Lee (Duke University)H-Index: 2
#2Samuel J Widmayer (NCSU: North Carolina State University)
Last.Douglas A. Marchuk (Duke University)H-Index: 66
view all 5 authors...
To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using quantitative trait locus (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. We had previously observed that infarct volume is inversely correlated with cerebral collateral vessel density in most strains. In this study, we expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the ...
Source
#1Han Kyu Lee (Duke University)H-Index: 2
#2Samuel J Widmayer (NCSU: North Carolina State University)
Last.Douglas A. Marchuk (Duke University)H-Index: 66
view all 5 authors...
To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using quantitative trait locus (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. We had previously observed that infarct volume is inversely correlated with cerebral collateral vessel density in the strains. In this study, we expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the C...
Source
#1Duane A. MitchellH-Index: 25
#2Kristen A. BatichH-Index: 9
Last.John H. SampsonH-Index: 72
view all 19 authors...
A clinical trial in patients with glioblastoma shows increased immune and anti-tumour responses to dendritic cell vaccination after pre-conditioning the site of vaccination with tetanus toxoid (Td); similar results are also seen in mice in part due to the actions of the chemokine CCL3, and the findings may represent new ways to improve the efficacy of anti-cancer vaccines.
207 CitationsSource
#1Ashley L. St. John (NUS: National University of Singapore)H-Index: 18
#2W.X. Gladys Ang (Duke University)H-Index: 3
Last.Soman N. AbrahamH-Index: 58
view all 7 authors...
Summary Pathologically swollen lymph nodes (LNs), or buboes, characterize Yersinia pestis infection, yet how they form and function is unknown. We report that colonization of the draining LN (dLN) occurred due to trafficking of infected dendritic cells and monocytes in temporally distinct waves in response to redundant chemotactic signals, including through CCR7, CCR2, and sphingosine-1-phospate (S1P) receptors. Retention of multiple subsets of phagocytes within peripheral LNs using the S1P rece...
29 CitationsSource
#1Sehoon Keum (Duke University)H-Index: 8
#2Han Kyu Lee (Duke University)H-Index: 2
Last.Douglas A. Marchuk (Duke University)H-Index: 66
view all 9 authors...
During ischemic stroke, occlusion of the cerebrovasculature causes neuronal cell death (infarction), but naturally occurring genetic factors modulating infarction have been difficult to identify in human populations. In a surgically induced mouse model of ischemic stroke, we have previously mapped Civq1 to distal chromosome 7 as a quantitative trait locus determining infarct volume. In this study, genome-wide association mapping using 32 inbred mouse strains and an additional linkage scan for in...
13 CitationsSource
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