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Simon Rasmussen
Technical University of Denmark
GenomeMetagenomicsPopulationGeneticsBiology
91Publications
35H-index
8,928Citations
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Publications 104
Newest
#1Katrine Højholt Iversen (DTU: Technical University of Denmark)H-Index: 2
#2Louise Hesselbjerg Rasmussen (Region Zealand)
Last. Flemming S. Rosenvinge (OUH: Odense University Hospital)H-Index: 11
view all 13 authors...
Streptococcus gordonii and Streptococcus sanguinis belong to the Mitis group streptococci, which mostly are commensals in the human oral cavity. Though they are oral commensals, they can escape their niche and cause infective endocarditis, a severe infection with high mortality. Several virulence factors important for the development of infective endocarditis have been described in these two species. However, the background for how the commensal bacteria, in some cases, become pathogenic is stil...
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#1Nina Vindegaard (Centre for Mental Health)H-Index: 1
#2Helene Speyer (Centre for Mental Health)H-Index: 1
Last. Michael Eriksen Benros (Centre for Mental Health)H-Index: 1
view all 5 authors...
Abstract Background Many diverse inflammatory pathophysiologic mechanisms have been linked to mental disorders, and through the past decade an increasing interest in the gut microbiota and its relation to mental health has been arising. We aimed to systematically review studies of alterations in gut microbiota of patients suffering from psychotic disorders, bipolar disorder or depression compared to healthy controls. Methods We systematically searched the databases CENTRAL, PubMed, EMBASE, PsycI...
1 CitationsSource
#1Rute R. da Fonseca (UCPH: University of Copenhagen)H-Index: 19
#2Alvarina Couto (University of Vigo)
Last. M. Thomas P. Gilbert (UCPH: University of Copenhagen)H-Index: 80
view all 44 authors...
Background The giant squid (Architeuthis dux; Steenstrup, 1857) is an enigmatic giant mollusc with a circumglobal distribution in the deep ocean, except in the high Arctic and Antarctic waters. The elusiveness of the species makes it difficult to study. Thus, having a genome assembled for this deep-sea–dwelling species will allow several pending evolutionary questions to be unlocked.
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#1T. Z. T. Jensen (Ebor: University of York)
#2Jonas Niemann (Ebor: University of York)H-Index: 1
Last. Hannes Schroeder (UCPH: University of Copenhagen)H-Index: 17
view all 22 authors...
The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland ...
1 CitationsSource
#1Ron Nudel (Lundbeck)H-Index: 3
#2Michael E. Benros (Copenhagen University Hospital)H-Index: 21
Last. Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 47
view all 16 authors...
Human leukocyte antigen (HLA) genes encode proteins with important roles in the regulation of the immune system. Many studies have also implicated HLA genes in psychiatric and neurodevelopmental disorders. However, these studies usually focus on one disorder and/or on one HLA candidate gene, often with small samples. Here, we access a large dataset of 65,534 genotyped individuals consisting of controls (N = 19,645) and cases having one or more of autism spectrum disorder (N = 12,331), attention ...
3 CitationsSource
#1Franziska Klincke (UCPH: University of Copenhagen)
#2Martin Abel-Kistrup (Chr. Hansen)H-Index: 2
Last. Simon Rasmussen (UCPH: University of Copenhagen)H-Index: 35
view all 4 authors...
An important step in metagenomics studies is to identify which species are present in a sample as well as to compare samples from different environments. Here we introduce MicroWineBar, a graphical tool for analyzing and comparing metagenomics samples. MicroWineBar can visualize the abundances of metagenomics samples in line and bar graphs, as well as analyse the richness and diversity. For a PCA as well as a differential abundance analysis, the abundance data is treated as compositional data an...
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#1Ashot Margaryan (UCPH: University of Copenhagen)H-Index: 12
#2Daniel J. Lawson (UoB: University of Bristol)H-Index: 46
Last. Eske WillerslevH-Index: 94
view all 85 authors...
The Viking maritime expansion from Scandinavia (Denmark, Norway, and Sweden) marks one of the swiftest and most far-flung cultural transformations in global history. During this time (c. 750 to 1050 CE), the Vikings reached most of western Eurasia, Greenland, and North America, and left a cultural legacy that persists till today. To understand the genetic structure and influence of the Viking expansion, we sequenced the genomes of 442 ancient humans from across Europe and Greenland ranging from ...
2 CitationsSource
#1Xueping Liu (Copenhagen University Hospital)H-Index: 1
#2Ron Nudel (CMHS: Mental Health Services)H-Index: 1
Last. Michael E. Benros (Copenhagen University Hospital)H-Index: 21
view all 15 authors...
Background: Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders. Methods: We used diagnostic information for patients with seven autoimmune diseases and six mental disorders from the Danish population-based case-cohort sample (iPSYCH2012). W...
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#1Martin Sikora (UCPH: University of Copenhagen)H-Index: 28
#2Vladimir V. Pitulko (RAS: Russian Academy of Sciences)H-Index: 16
Last. Eske WillerslevH-Index: 94
view all 54 authors...
Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through analyses of 34 newly recovered ancient genomes that date to between 31,000 and 600 years ago. We document complex population dynamics during this period, including at least three major migration events: an initial peopling by a previously unknown Palaeolithic population o...
5 CitationsSource
#1Hannes Schroeder (UCPH: University of Copenhagen)H-Index: 17
#2Ashot Margaryan (Armenian National Academy of Sciences)H-Index: 12
Last. Morten E. Allentoft (UCPH: University of Copenhagen)H-Index: 28
view all 23 authors...
The third millennium BCE was a period of major cultural and demographic changes in Europe that signaled the beginning of the Bronze Age. People from the Pontic steppe expanded westward, leading to the formation of the Corded Ware complex and transforming the genetic landscape of Europe. At the time, the Globular Amphora culture (3300–2700 BCE) existed over large parts of Central and Eastern Europe, but little is known about their interaction with neighboring Corded Ware groups and steppe societi...
2 CitationsSource
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