Sunelle A. Barnard
North-West University
EndocrinologyPlasminogen activatorMetabolic syndromePlasminogen activator inhibitor-1Diabetes mellitus
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Publications 4
#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
#2Wayne Smith (NWU: North-West University)H-Index: 10
Last. Aletta E. Schutte (NWU: North-West University)H-Index: 44
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Abstract Introduction Low circulating levels of insulin-like growth factor-1 (IGF-1) are associated with endothelial dysfunction, subsequently leading to the development of cardiovascular disease. Objective To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor anti...
#1Marlien PietersH-Index: 16
#2Sunelle A. BarnardH-Index: 3
Last. Dingeman C. RijkenH-Index: 24
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textabstractDue to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. Blood samples were collected from 151 individuals and centrifuged at 352 and 1500 g to obtain plasma with varying numbers of platelet. In a follow-up study, bloo...
4 CitationsSource
#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
#2Marlien Pieters (NWU: North-West University)H-Index: 16
Last. Zelda de Lange (NWU: North-West University)H-Index: 6
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Increased plasma plasminogen activator inhibitor-1 (PAI-1) level is considered a mechanistic pathway through which obesity contributes to increased cardiovascular disease risk. Abdominal adipose tissue specifically, is a major PAI-1 source with visceral adipose tissue (VAT), an ectopic fat depot, generally considered to produce more PAI-1 than subcutaneous adipose tissue. However, this does not necessarily lead to increased plasma PAI-1 levels. This review provides an overview of studies investi...
10 CitationsSource
#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
#2Marlien Pieters (NWU: North-West University)H-Index: 16
Last. Herculina S. Kruger (NWU: North-West University)H-Index: 22
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Abstract Introduction Although the relationship of plasminogen activator inhibitor-1 (PAI-1) with obesity has been well established, the relationship of PAI-1 with different body fat distribution patterns is less clear particularly in non-white ethnicities. Methods We investigated the cross-sectional association of PAI-1act with body fat % and two different body fat distribution patterns, namely sarcopenic obesity (SO) and visceral (VAT) compared to subcutaneous (SCAT) abdominal obesity, in 246 ...
3 CitationsSource