SurgeryLiver transplantationTransplantationDiabetes mellitusMedicine
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Publications 424
#1Pim B. OlthofH-Index: 10
#2Luca AldrighettiH-Index: 40
Last. Ernesto SparrelidH-Index: 8
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In the original article Moritz Schmelzle’s last name is spelled wrong. It is correct as reflected here.
#1Jun Li (UHH: University of Hamburg)H-Index: 26
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Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at the advanced stage. The aim of the study was to verify the surgical and oncological outcome of ALPPS for intrahepatic cholangiocarcinoma (ICC).
2 CitationsSource
#2Dimitri A. RaptisH-Index: 26
Last. Henrik PetrowskyH-Index: 28
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OBJECTIVE: The aims of the present study were to identify independent risk factors for conduit occlusion, compare outcomes of different AC placement sites, and investigate whether postoperative platelet antiaggregation is protective. BACKGROUND: Arterial conduits (AC) in liver transplantation (LT) offer an effective rescue option when regular arterial graft revascularization is not feasible. However, the role of the conduit placement site and postoperative antiaggregation is insufficiently answe...
#2D. Aranovich (Rabin Medical Center)
Last. J.-M. Regimbeau (University of Picardie Jules Verne)
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Approximately 10% of patients with ascites associated with cirrhosis fail to respond to dietary rules and diuretic treatment and therefore present with refractory ascites. In order to avoid iterative large-volume paracentesis in patients with contraindication to TIPS, the automated low flow ascites pump system (Alfapump) was developed to pump ascites from the peritoneal cavity into the urinary bladder, where it is eliminated spontaneously by normal micturition. This manuscript reports the surgic...
#1Giuseppe MazzaH-Index: 9
#2A TeleseH-Index: 1
Last. Krista RomboutsH-Index: 15
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An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify and validate new therapeutic targets for HCC. The aim of this work was to validate a new in vitro model based on engineering three-dimensional (3D) healthy and cirrhotic human liver scaffolds with HCC...
1 CitationsSource
#1Christina Fotopoulou (Imperial College London)H-Index: 22
#2Thomas BergH-Index: 74
Last. Guido Stirnimann (University of Bern)H-Index: 7
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Malignant Ascites (MA) is a therapeutic dilemma significantly impairing patients’ quality of life (QoL). The Sequana Medical alfapump System (AP), a subcutaneous, externally rechargeable, implantable device, continually draining ascites via the urinary bladder, has been well established in liver cirrhosis, but not yet in MA. The AP-system was evaluated in cancer patients in reducing the need for large volume paracentesis (LVP). A retrospective multicentre evaluation of all eligible patients who ...
#1Tim Reese (Semmelweis University)H-Index: 1
#1Tim ReeseH-Index: 2
Last. Karl J. OldhaferH-Index: 28
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Background Impaired postoperative renal function is associated with increased morbidity and mortality after liver resection. The role of impaired renal function in the two-stage hepatectomy setting of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is unknown.
#1Dimitri A. RaptisH-Index: 26
#2Michael LineckerH-Index: 13
Last. P.-A. ClavienH-Index: 97
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Objective:The aim of this study was to use the concept of benchmarking to establish robust and standardized outcome references after the procedure ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy).Background and Aims:The recently developed ALPPS procedure, aiming at
#1Michael Linecker (UZH: University of Zurich)H-Index: 13
#2Patryk Kambakamba (UZH: University of Zurich)H-Index: 9
Last. Andrea Frilling (Imperial College London)H-Index: 41
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Abstract Background Surgery is the most effective treatment option for neuroendocrine liver metastases (NELM). This study investigated the role of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) as a novel strategy in treatment of NELM. Methods The International ALPPS Registry was reviewed to study patients who underwent ALPPS for NELM. Results From 2010 to 2017, 954 ALPPS procedures from 135 international centers were recorded in the International ALPPS Regis...
#2Vessela VassilevaH-Index: 8
Last. Stephen P. PereiraH-Index: 43
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Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), has been associated with poor prognosis in various malignancies. Targeting these enzymes could attenuate aerobic glycolysis and inhibit tumor proliferation. We investigated whether the PKM2 activator, TEPP-46, and the LDHA inhibitor, FX-11, can be combined to inhibit in vitro and in vivo tumor growth in precli...