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Deborah J. Bowen
University of Washington
457Publications
60H-index
16.3kCitations
Publications 457
Newest
Published on Dec 1, 2019in BMC Cancer 2.93
Nadine Rayes (University of Texas MD Anderson Cancer Center), Deborah J. Bowen60
Estimated H-index: 60
(UW: University of Washington)
+ 13 AuthorsDeborah Polinsky
Background Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased availability and lower costs of multiplex cancer gene panels, there remains a gap in genetics services that has not been addressed by the current care delivery models. Lower cost of DNA sequencing with online patient-initiated ordering could increase test availability, but the ide...
Published on Jan 11, 2019in Leukemia 9.94
Detlef Haase38
Estimated H-index: 38
(GAU: University of Göttingen),
Kristen E. Stevenson38
Estimated H-index: 38
(Harvard University)
+ 47 AuthorsTorsten Haferlach81
Estimated H-index: 81
Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnormalities and somatic mutations. To refine risk stratification of CK-MDS patients, we examined data from 359 CK-MDS patients shared by the International Working Group for MDS. Mutations were underrepres...
Published on Jun 1, 2019in American Journal of Human Genetics 9.92
Sarah Nelson21
Estimated H-index: 21
(UW: University of Washington),
Deborah J. Bowen60
Estimated H-index: 60
(UW: University of Washington),
Stephanie M. Fullerton32
Estimated H-index: 32
(UW: University of Washington)
In an effort to meet ethical obligations and/or participant expectations, researchers may consider offering "raw" or uninterpreted genetic data for result return. It is therefore important to understand the motivations, behaviors, and perspectives of individuals who might choose to access raw data before such return becomes routine. In the direct-to-consumer (DTC) context, where raw data are often made available to customers, the use of third-party interpretation tools has raised concerns about ...
Published on Dec 31, 2018in Journal of Genetic Counseling 2.45
Ginger J. Tsai1
Estimated H-index: 1
(UW: University of Washington),
Lauren Thomas Garrett2
Estimated H-index: 2
(UW: University of Washington)
+ 3 AuthorsBrian H. Shirts22
Estimated H-index: 22
(UW: University of Washington)
Published on Oct 30, 2018in Genetics in Medicine 8.68
Ginger J. Tsai1
Estimated H-index: 1
(UW: University of Washington),
John Michael O. Ranola3
Estimated H-index: 3
(UW: University of Washington)
+ 5 AuthorsBrian H. Shirts22
Estimated H-index: 22
(UW: University of Washington)
Family studies are an important but underreported source of information for reclassification of variants of uncertain significance (VUS). We evaluated outcomes of a patient-driven framework that offered familial VUS reclassification analysis to any adult with any clinically ascertained VUS from any laboratory in the United States. With guidance from FindMyVariant.org, participants recruited their own relatives for study participation. We genotyped relatives, calculated quantitative cosegregation...
Published on May 16, 2019in Translational behavioral medicine 2.24
Tara Coffin1
Estimated H-index: 1
(UW: University of Washington),
Yelena P. Wu16
Estimated H-index: 16
(UofU: University of Utah)
+ 3 AuthorsDeborah J. Bowen60
Estimated H-index: 60
(UW: University of Washington)
Published on Apr 1, 2019in Journal of Genetic Counseling 2.45
Sukh Makhnoon1
Estimated H-index: 1
(UW: University of Washington),
Brian H. Shirts22
Estimated H-index: 22
(UW: University of Washington),
Deborah J. Bowen60
Estimated H-index: 60
(UW: University of Washington)
Published on Apr 1, 2019in Journal of Community Genetics
Sukh Makhnoon1
Estimated H-index: 1
(UW: University of Washington),
Lauren Thomas Garrett2
Estimated H-index: 2
(UW: University of Washington)
+ 2 AuthorsBrian H. Shirts22
Estimated H-index: 22
(UW: University of Washington)
Patients’ understanding of a genetic variant of unknown clinical significance (VUS) is likely to influence beliefs about risk implications, consequent medical decisions, and other actions such as involvement in research. We interviewed 26 self-selected participants with a clinically identified VUS before they enrolled into a VUS reclassification study. Semi-structured interviews addressed topics including motivation to get genetic test, experience with the VUS result, affective responses to rece...
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