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Aurélie Trenado
Centre national de la recherche scientifique
ImmunologyHematopoietic stem cell transplantationGraft-versus-host diseaseIL-2 receptorImmune system
8Publications
7H-index
1,618Citations
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Publications 8
Newest
#1Muriel Sudres (CNRS: Centre national de la recherche scientifique)H-Index: 4
#2Françoise NorolH-Index: 15
Last. José L. Cohen (CNRS: Centre national de la recherche scientifique)H-Index: 24
view all 12 authors...
Several reports have suggested that mesenchymal stem cells (MSCs) could exert a potent immunosuppressive effect in vitro, and thus may have a therapeutic potential for T cell-dependent pathologies. We aimed to establish whether MSCs could be used to control graft-vs-host disease (GVHD), a major cause of morbidity and mortality after allogeneic hemopoietic stem cell transplantation. From C57BL/6 and BALB/c mouse bone marrow cells, we purified and expanded MSCs characterized by the lack of express...
307 CitationsSource
#1Sylvain Fisson (UPMC: Pierre-and-Marie-Curie University)H-Index: 16
#2Fathia Djelti (UPMC: Pierre-and-Marie-Curie University)H-Index: 8
Last. Benoît L. Salomon (UPMC: Pierre-and-Marie-Curie University)H-Index: 36
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CD4+CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self-antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self-antigen-specific Treg naturally present in a polyclonal repertoire of Treg is of major importance. In this work, we investigated the potential of different dendritic cell (DC) subsets to expand antigen-...
48 CitationsSource
#1Aurélie TrenadoH-Index: 7
#2Muriel SudresH-Index: 4
Last. José L. CohenH-Index: 24
view all 10 authors...
CD4 + CD25 + immunoregulatory T cells (Tregs) can be administered to inhibit graft-vs-host disease (GVHD) while preserving graft-vs-leukemia activity after allogeneic bone marrow transplantation in mice. Preclinical studies suggest that it is necessary to infuse as many Tregs as conventional donor T cells to achieve a clinical effect on GVHD. Thus, it would be necessary to expand Tregs ex vivo before transplantation. Two strategies have been proposed: expansion of Tregs stimulated by anti-CD3/CD...
118 CitationsSource
#1Stephane Trajcevski (UPMC: Pierre-and-Marie-Curie University)H-Index: 4
#2Sounkary K. Solly (UPMC: Pierre-and-Marie-Curie University)H-Index: 6
Last. David Klatzmann (UPMC: Pierre-and-Marie-Curie University)H-Index: 63
view all 6 authors...
Background Recently, several cancer gene therapy studies have shown that replication-competent retroviral vectors represent a major improvement over replication-defective ones in terms of transgene propagation efficiency. However, this positive effect is somewhat spoiled by the increased risk of dissemination and oncogenesis that replication-competent retroviral vectors entail. To enhance both their integral safety and their transgene capacity, we developed a semi-replication-competent retrovira...
14 CitationsSource
#1Aurélie TrenadoH-Index: 7
#2Sylvain FissonH-Index: 16
Last. José L. CohenH-Index: 24
view all 6 authors...
Allogeneic hematopoietic stem-cell transplantation (HSCT) is the treatment of choice for many malignant and nonmalignant hematologic disorders. Donor T cells present in the hematopoietic stem-cell transplant improve engraftment and immune reconstitution and contribute to the graft-versus-leukemia effect, but are also responsible for the life-threatening graft-versus-host disease (GVHD). CD4 + CD25 + immunoregulatory T cells, which play a pivotal role in preventing organ-specific diseases, can al...
24 CitationsSource
#1Aurélie TrenadoH-Index: 7
#2Frédéric Charlotte (UPMC: Pierre-and-Marie-Curie University)H-Index: 64
Last. José L. CohenH-Index: 24
view all 7 authors...
CD4+CD25+ regulatory T cells (Treg’s) play a pivotal role in preventing organ-specific autoimmune diseases and in inducing tolerance to allogeneic organ transplants. We and others recently demonstrated that high numbers of Treg’s can also modulate graft-versus-host disease (GVHD) if administered in conjunction with allogeneic hematopoietic stem cell transplantation in mice. In a clinical setting, it would be impossible to obtain enough freshly purified Treg’s from a single donor to have a therap...
446 CitationsSource
#1Aurélie TrenadoH-Index: 7
Last. José L. CohenH-Index: 24
view all 7 authors...
CD4 + CD25 + regulatory T cells (Treg’s) play a pivotal role in preventing organ-specific autoimmune diseases and in inducing tolerance to allogeneic organ transplants. We and others recently demonstrated that high numbers of Treg’s can also modulate graft-versus-host disease (GVHD) if administered in conjunction with allogeneic hematopoietic stem cell transplantation in mice. In a clinical setting, it would be impossible to obtain enough freshly purified Treg’s from a single donor to have a the...
CD4+CD25+ immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we show that the few CD4+CD25+ T cells naturally present in the transplant regulate GVHD because their removal from the graft dramatically accelerates thi...
661 CitationsSource
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