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Futao Zhang
University of Queensland
36Publications
12H-index
1,620Citations
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Publications 45
Newest
#1Anke R. Hammerschlag (PHRI: Public Health Research Institute)
#2Enda M. Byrne (UQ: University of Queensland)H-Index: 33
Last. Wibowo ArindrartoH-Index: 8
view all 123 authors...
Abstract Background Recent genome-wide association studies (GWAS) identified the first genetic loci associated with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The next step is to use these results to increase our understanding of the biological mechanisms involved. Most of the identified variants likely influence gene regulation. The aim of the current study is to shed light on the mechanisms underlying the genetic signals and prioritize genes by integrat...
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#1Yang Wu (UQ: University of Queensland)H-Index: 13
#2Ting Qi (UQ: University of Queensland)H-Index: 5
Last. Jian Zeng (UQ: University of Queensland)H-Index: 11
view all 11 authors...
Promoter-anchored chromatin interactions (PAIs) play a pivotal role in transcriptional regulation. Current high-throughput technologies for detecting PAIs, such as promoter capture Hi-C, are not scalable to large cohorts. Here, we present an analytical approach that uses summary-level data from cohort-based DNA methylation (DNAm) quantitative trait locus (mQTL) studies to predict PAIs. Using mQTL data from human peripheral blood ([Formula: see text]), we predict 34,797 PAIs which show strong ove...
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#1Baptiste Couvy-Duchesne (UQ: University of Queensland)H-Index: 11
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 8 authors...
We evaluated the statistical power, family wise error rate (FWER) and precision of several competing methods that perform mass-univariate vertex-wise analyses of grey-matter (thickness and surface area). In particular, we compared several generalised linear models (GLMs, current state of the art) to linear mixed models (LMMs) that have proven superior in genomics. We used phenotypes simulated from real vertex-wise data and a large sample size (N=8,662) which may soon become the norm in neuroimag...
#1Azmeraw T. Amare (University of Adelaide)H-Index: 40
#3Klaus Oliver Schubert (University of Adelaide)H-Index: 9
Last. Fasil Tekola-Ayele (NIH: National Institutes of Health)H-Index: 13
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Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtain...
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#1Costanza L. Vallerga (UQ: University of Queensland)H-Index: 6
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Leanne Wallace (UQ: University of Queensland)H-Index: 12
view all 30 authors...
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a blood-based methylome-wide association study of PD involving meta-analysis of 229 K CpG probes in 1,132 cases and 999 controls from two independent cohorts. We identify two previously unreported epigenome-wide significant associations with PD, including cg06690548 on chromosome ...
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#1Marta F. Nabais (UQ: University of Queensland)H-Index: 1
#1Marta F. Nabais (UQ: University of Queensland)
Last. Anna Freydenzon (UQ: University of Queensland)
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We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown i...
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#2Futao ZhangH-Index: 12
Last. Archie CampbellH-Index: 24
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#2Futao ZhangH-Index: 12
Last. Riccardo E. MarioniH-Index: 40
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Availability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to access@generationscotland.org. Full summary statistics for the analyses presented are publicly available online at https://doi.org/10.7488/ds/2709. Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the S...
1 CitationsSource
#1Yang Wu (UQ: University of Queensland)H-Index: 13
#2Ting Qi (UQ: University of Queensland)H-Index: 5
Last. Jian Yang (UQ: University of Queensland)H-Index: 97
view all 11 authors...
Promoter-anchored chromatin interactions (PAIs) play a pivotal role in transcriptional regulation. Current high-throughput technologies for detecting PAIs, such as promoter capture Hi-C, are often limited in sample size due to the complexity of the experiments. Here, we present an analytical approach that uses summary-level data from DNA methylation (DNAm) quantitative trait locus (mQTL) studies to predict PAIs. Using mQTL data from human peripheral blood (n=1,980), we predicted 34,797 PAIs whic...
Source
#1Mike A. Nalls (NIH: National Institutes of Health)H-Index: 70
#2Cornelis Blauwendraat (NIH: National Institutes of Health)H-Index: 11
Last. Futao ZhangH-Index: 12
view all 232 authors...
Summary Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated ...
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