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Paul A. Iaizzo
University of Minnesota
AnatomySurgeryCardiologyAnesthesiaMedicine
486Publications
34H-index
5,331Citations
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Publications 456
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#2Kaiyan QiuH-Index: 9
Last. Michael C. McAlpineH-Index: 32
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#1Hiba J. Mustafa (UMN: University of Minnesota)
#2Weston Upchurch (UMN: University of Minnesota)H-Index: 1
Last. Gill Lisa (UMN: University of Minnesota)
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#1Lauren MacCormick Tatman (UMN: University of Minnesota)
#2Weston Upchurch (UMN: University of Minnesota)H-Index: 1
Last. Paul A. Iaizzo (UMN: University of Minnesota)H-Index: 34
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OBJECTIVES: To identify potential physiologic markers of muscle ischemia to serve as diagnostic indicators of compartment syndrome. We hypothesize that muscle bundles in hypoxic conditions will elicit decreases in potential hydrogen (pH) and increases in lactate and potassium that correlates with decreased muscle twitch forces. METHODS: We performed an ex vivo evaluation of individual skeletal muscle bundles obtained from a swine's diaphragm that were exposed to hypoxic conditions and compared t...
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#1Karim Azzag (UMN: University of Minnesota)H-Index: 2
#2Carolina Ortiz-Cordero (UMN: University of Minnesota)
Last. Rita C. R. Perlingeiro (UMN: University of Minnesota)H-Index: 29
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BACKGROUND: Defects in alpha-dystroglycan (DG) glycosylation characterize a group of muscular dystrophies known as dystroglycanopathies. One of the key effectors in the alpha-DG glycosylation pathway is the glycosyltransferase fukutin-related protein (FKRP). Mutations in FKRP lead to a large spectrum of muscular dystrophies, including limb girdle muscular dystrophy 2I (LGMD2I). It remains unknown whether stem cell transplantation can promote muscle regeneration and ameliorate the muscle wasting ...
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Last. Paul A. IaizzoH-Index: 34
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#1Renee Brigham (UMN: University of Minnesota)
#2Mikayle A. Holm (UMN: University of Minnesota)
Last. Paul A. Iaizzo (UMN: University of Minnesota)H-Index: 34
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#1Mikayle A. Holm (UMN: University of Minnesota)
#2Alex Deakyne (UMN: University of Minnesota)
Last. Paul A. Iaizzo (UMN: University of Minnesota)H-Index: 34
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#1Jorge D. Zhingre Sanchez (UMN: University of Minnesota)H-Index: 1
#1Jorge D. Zhingre Sanchez (UMN: University of Minnesota)H-Index: 6
Last. Paul A. IaizzoH-Index: 34
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1 CitationsSource
#1D.A. Ramirez (UMN: University of Minnesota)
#2W. Upchurch (UMN: University of Minnesota)
Last. Paul A. Iaizzo (UMN: University of Minnesota)H-Index: 34
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Purpose Heart transplantation is commonly considered to be the only option available for patients with congenital heart defects and/or individuals with terminal heart failure. Myocardial ischemia-reperfusion injury (IRI) can damage the heart and prolong recovery. Common complications of IRI include graft rejection, cardiac allograft vasculopathy, graft dysfunction, and chronic kidney disease. Solutions of omega-3/omega-6 fatty acids and bear bile acids have been found to attenuate IRI. This stud...
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#1John R. Spratt (UMN: University of Minnesota)H-Index: 4
#2Lars M. Mattison (UMN: University of Minnesota)H-Index: 3
Last. Paul A. Iaizzo (UMN: University of Minnesota)H-Index: 34
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Many lung donor offers are refused despite increasing demand. Portable normothermic ex vivo lung perfusion (EVLP) could increase donor yield by monitoring and reconditioning extended criteria donor (ECD) lungs. We report its use in human lungs declined for clinical transplantation. Ten sets of such lungs were procured from brain-dead donors and underwent 24 hours of normothermic EVLP using a perfusate based on donor whole blood. Hemodynamic and ventilatory data and P:F ratios were measured. Adva...
1 CitationsSource
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