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Clive J. Naylor
University of Liverpool
78Publications
18H-index
816Citations
Publications 78
Newest
#1A. Laconi (University of Liverpool)H-Index: 3
#2Elena Catelli (UNIBO: University of Bologna)H-Index: 13
Last.Clive J. Naylor (University of Liverpool)H-Index: 18
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Abstract Since late ‘80 s Avian metapneumovirus subtype A causes sufficient disease in Europe for commercial companies to have started developing live attenuated vaccines. Here, two of those vaccines were fully consensus sequenced alongside their progenitor field strain (#8544). Sequences comparison shows that the attenuation of field strain #8544 was associated with no common substitutions between the two derived vaccines. This finding suggests that the attenuation of field viruses via serial p...
Source
#1A. Laconi (University of Liverpool)H-Index: 3
#2Valeria Listorti (UNIBO: University of Bologna)H-Index: 5
Last.E. Catelli (UNIBO: University of Bologna)H-Index: 4
view all 7 authors...
2 CitationsSource
#1Valeria Listorti (University of Liverpool)H-Index: 5
#2A. Laconi (University of Liverpool)H-Index: 3
Last.Clive J. Naylor (University of Liverpool)H-Index: 18
view all 6 authors...
Abstract IBV genotype QX causes sufficient disease in Europe for several commercial companies to have started developing live attenuated vaccines. Here, one of those vaccines (L1148) was fully consensus sequenced alongside its progenitor field strain (1148-A) to determine vaccine markers, thereby enabling detection on farms. Twenty-eight single nucleotide substitutions were associated with the 1148-A attenuation, of which any combination can identify vaccine L1148 in the field. Sixteen substitut...
3 CitationsSource
#2A. LaconiH-Index: 3
Last.Clive J. NaylorH-Index: 18
view all 7 authors...
#1A. Laconi (University of Liverpool)H-Index: 3
#2Jayne Clubbe (University of Liverpool)H-Index: 3
Last.Clive J. Naylor (University of Liverpool)H-Index: 18
view all 8 authors...
Avian metapneumovirus (AMPV) infection of poultry causes serious disease in most countries and subtype A reverse-genetic (RG) systems have allowed a generation of viruses of known sequence, and proved useful in developments towards better control by live vaccines. While subtype B viruses are more prevalent, bacterial cloning issues made subtype B RG systems difficult to establish. A molecular comparison of subtype A and B viruses was undertaken to assess whether subtype A RG components could be ...
2 CitationsSource
#1Giovanni FranzoH-Index: 11
#2Clive J. NaylorH-Index: 18
Last.Mattia CecchinatoH-Index: 13
view all 8 authors...
#1Giovanni Franzo (UNIPD: University of Padua)H-Index: 11
#2Valeria Listorti (UNIBO: University of Bologna)H-Index: 5
Last.Mattia Cecchinato (UNIPD: University of Padua)H-Index: 13
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Abstract Since 1996 a new Infectious Bronchitis virus (IBV) genotype, referred to as Q1, circulated in China and was reported for the first time in Italy in 2011, associated with an increase of mortality, kidney lesions and proventriculitis. During northern Italian outbreak of respiratory disease in a broiler flock in 2013, an IBV strain was detected by RT-PCR and characterized as Q1-like based on partial S1 sequence. The virus was isolated and named γCoV/Ck/Italy/I2022/13. All coding regions of...
10 CitationsSource
#1Giovanni Franzo (UNIPD: University of Padua)H-Index: 11
#2Clive J. Naylor (University of Liverpool)H-Index: 18
Last.Mattia Cecchinato (UNIPD: University of Padua)H-Index: 13
view all 8 authors...
Abstract Avian metapneumovirus (aMPV) infects respiratory and reproductive tracts of domestic poultry, often involving secondary infections, and leads to serious economic losses in most parts of the world. While in general disease is effectively controlled by live vaccines, reversion to virulence of those vaccines has been demonstrated on several occasions. Consensus sequence mutations involved in the process have been identified in more than one instance. In one previous subtype A aMPV candidat...
3 CitationsSource
#1Giovanni FranzoH-Index: 11
#2Clive J. NaylorH-Index: 18
Last.Cecchinato MattiaH-Index: 6
view all 7 authors...
#1Giovanni FranzoH-Index: 11
#2Clive J. NaylorH-Index: 18
Last.Cecchinato MattiaH-Index: 6
view all 8 authors...
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