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Andrew D. Grotzinger
University of Texas at Austin
36Publications
9H-index
206Citations
Publications 36
Newest
#1Alexis C. Wood (BCM: Baylor College of Medicine)H-Index: 4
#2Uku Vainik (UT: University of Tartu)H-Index: 10
Last.Elliot M. Tucker-Drob (University of Texas at Austin)H-Index: 31
view all 8 authors...
#1Javier de la Fuente (University of Texas at Austin)
#2Gail Davies (Edin.: University of Edinburgh)H-Index: 52
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 5 authors...
It has been known for 115 years that, in humans, diverse cognitive traits are positively intercorrelated; this forms the basis for the general factor of intelligence (g). We directly test for a genetic basis for g using data from seven different cognitive tests (N = 11,263 to N = 331,679) and genome-wide autosomal single nucleotide polymorphisms. A genetic g factor accounts for 58.4% (SE = 4.8%) of the genetic variance in the cognitive traits, with trait-specific genetic factors accounting for t...
#1Mona Ayoub (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
#2Daniel Andrew Briley (UIUC: University of Illinois at Urbana–Champaign)H-Index: 16
Last.Elliot M. Tucker-Drob (University of Texas at Austin)H-Index: 31
view all 8 authors...
Parenting is often conceptualized in terms of its effects on offspring. However, children may also play an active role in influencing the parenting they receive. Simple correlations between parenti...
#1Margherita Malanchini (QMUL: Queen Mary University of London)H-Index: 5
#2Laura E. Engelhardt (University of Texas at Austin)H-Index: 11
Last.Elliot M. Tucker-Drob (University of Texas at Austin)H-Index: 31
view all 11 authors...
The progression of lifelong trajectories of socioeconomic inequalities in health and mortality begins in childhood. Dysregulation in cortisol, a stress hormone that is the primary output of the hypothalamus-pituitary-adrenal (HPA) axis, has been hypothesized to be a mechanism for how early environmental adversity compromises health. However, despite the popularity of cortisol as a biomarker for stress and adversity, little is known about whether cortisol output differs in children being raised i...
#1Ben Michael Brumpton (Medical Research Council)H-Index: 9
#2Eleanor Sanderson (UoB: University of Bristol)H-Index: 5
Last.Neil M Davies (UoB: University of Bristol)H-Index: 23
view all 30 authors...
Mendelian randomization (MR) is a widely-used method for causal inference using genetic data. Mendelian randomization studies of unrelated individuals may be susceptible to bias from family structure, for example, through dynastic effects which occur when parental genotypes directly affect offspring phenotypes. Here we describe methods for within-family Mendelian randomization and through simulations show that family-based methods can overcome bias due to dynastic effects. We illustrate these is...
#1James W. Madole (University of Texas at Austin)H-Index: 1
#2Mijke Rhe (UC Davis: University of California, Davis)H-Index: 21
Last.K. Paige Harden (University of Texas at Austin)H-Index: 30
view all 5 authors...
Comorbidity is pervasive across psychopathological symptoms, diagnoses, and domains. Network analysis is a method for investigating symptom-level associations that underlie comorbidity, particularl...
#1K. Paige Harden (University of Texas at Austin)H-Index: 30
#2Laura E. Engelhardt (University of Texas at Austin)H-Index: 11
Last.Elliot M. Tucker-Drob (University of Texas at Austin)H-Index: 31
view all 11 authors...
Objective Symptoms of psychopathology covary across diagnostic boundaries, and a family history of elevated symptoms for a single psychiatric disorder places an individual at heightened risk for a broad range of other psychiatric disorders. Both twin-based and genome-wide molecular methods indicate a strong genetic basis for the familial aggregation of psychiatric disease. This has led researchers to prioritize the search for highly heritable childhood risk factors for transdiagnostic psychopath...
#1Andrew D. Grotzinger (University of Texas at Austin)H-Index: 9
#2Mijke Rhe (UC Davis: University of California, Davis)H-Index: 21
Last.Elliot M. Tucker-Drob (University of Texas at Austin)H-Index: 31
view all 14 authors...
Genetic correlations estimated from genome-wide association studies (GWASs) reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modelling (genomic SEM): a multivariate method for analysing the joint genetic architecture of complex traits. Genomic SEM synthesizes genetic correlations and single-nucleotide polymorphism heritabilities inferred from GWAS summary statistics of individual traits from samples with varying and unknown degrees of over...
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