Match!
Timothy J. Barnes
University of South Australia
AdsorptionChemistryPorous siliconChromatographyDendrimer
43Publications
20H-index
1,005Citations
What is this?
Publications 44
Newest
#1Feng WangH-Index: 2
#2Timothy J. BarnesH-Index: 20
Last. Clive A. PrestidgeH-Index: 39
view all 3 authors...
Porous silicon (pSi) continues to receive considerable interest for use in applications ranging from sensors, biological scaffolds, therapeutic delivery systems to theranostics. Critical to all of these applications is pSi degradation and stabilization in biological media. Here we report on progress towards the development of a mechanistic understanding for the dissolution behavior of native (unoxidized) and thermally oxidized (200–600 °C) pSi microparticles. Fourier transform infrared (FTIR) sp...
Source
#1Jin Jau LiauH-Index: 1
#2Clive A. PrestidgeH-Index: 39
Last. Timothy J. BarnesH-Index: 20
view all 4 authors...
1 CitationsSource
#1Paul Joyce (UniSA: University of South Australia)H-Index: 8
#2Timothy J. Barnes (UniSA: University of South Australia)H-Index: 20
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
view all 4 authors...
A combination of proton nuclear magnetic resonance (1H NMR) and synchrotron small-angle X-ray scattering (sSAXS) was used to discriminate the speciation and structure evolution of lipolysis products for submicron lipid droplets and lipid loaded in porous silica particles. The free fatty acid (FFA)-to-glyceride ratio was controlled by confining medium-chain length triglycerides (MCT) in porous silica particles, which influenced the colloidal self-assembly structures formed within the lipolysis me...
16 CitationsSource
#1Patrick K.C. Chang (UniSA: University of South Australia)H-Index: 2
#2Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
Last. Kristen E. Bremmell (UniSA: University of South Australia)H-Index: 12
view all 4 authors...
Improvement in the in vitro and in vivo stability of biotherapeutic proteins has been approached via a number of strategies, including protein PEGylation or formulation with non-ionic surfactants. Here we report on interaction and stability studies for the biotherapeutic protein filgrastim (granulocyte stimulating factor (G-CSF)) and its PEGylated analogue (PEG-GCSF), with polysorbate 20, using isothermal calorimetry, circular dichroism, surface tension and dynamic light scattering measurements....
3 CitationsSource
#1Jin Jau Liau (UniSA: University of South Australia)H-Index: 1
#2Sarah Hook (University of Otago)H-Index: 28
Last. Timothy J. Barnes (UniSA: University of South Australia)H-Index: 20
view all 4 authors...
The gastric mucosa provides the entry point for the majority of pathogens, as well as being the induction site for protective immunity; however, there remain few examples of oral vaccines due to the challenges presented by the gastrointestinal route. In this study, we develop a lipid-based multi-compartmental system for oral vaccine delivery. Specifically, we have optimised the formulation of a water-in-oil-in-water double emulsion prepared from a triglyceride – soya bean oil, using surfactants ...
10 CitationsSource
#1Achal B. BhattH-Index: 2
#2Timothy J. BarnesH-Index: 20
Last. Clive A. PrestidgeH-Index: 39
view all 3 authors...
The high internal surface area and drug solubilizing capacity of liquid crystal lipids makes them promising oral drug delivery systems. Pluronic F127 is typically used to disperse highly viscous cubic liquid crystal lipids into cubosomes; however, such copolymers alter the internal structure and provide little control over enzymatic digestion. This study aimed to use hydrophilic silica nanoparticles to stabilize glyceryl monooleate (GMO) cubosomes prepared by ultrasonication. We investigate the ...
8 CitationsSource
6 CitationsSource
#1Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
#2Timothy J. Barnes (UniSA: University of South Australia)H-Index: 20
Abstract: With the abundance of poorly soluble drug candidates currently under investigation in the drug development pipeline, there is a significant imperative to develop methodologies to control and improve their in vivo behaviour. Porous silicon (PSi) has received considerable attention for the delivery of a range of poorly soluble therapeutics, which are typically loaded by solvent partitioning. Due to steric crowding of the drug molecules in the pores, the drugs remain ‘frozen’ in highly so...
Source
#1Feng WangH-Index: 2
#2Timothy J. BarnesH-Index: 20
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
view all 3 authors...
We investigate the physicochemical characteristics of celecoxib (CEL) entrapped within particles of an oxidized porous silicon matrix (pSiox); determine the oral dose response of CEL compared to pure drug and innovator formulation; develop in vivo-in vitro correlation (IVIVC). CEL was loaded into a pSiox matrix by solvent partitioning, with the physical state of the CEL characterized by FTIR, DSC, TGA and XRD, and correlated with in vitro dissolution behavior. Single dose pharmacokinetic paramet...
3 CitationsSource
#1Biplab Roy (University of North Bengal)H-Index: 6
#2Amiya Kumar Panda (University of North Bengal)H-Index: 1
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
view all 6 authors...
5 CitationsSource
12345