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Akatsuki Saito
Osaka University
VirologyCapsidImmunologyVirusBiology
43Publications
14H-index
408Citations
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Publications 45
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#1Akatsuki Saito (Osaka University)H-Index: 14
#2Tahmina Sultana (Osaka University)H-Index: 2
Last. Tatsuo Shioda (Osaka University)H-Index: 37
view all 8 authors...
Binding of HIV-1 capsid (CA) to cleavage and polyadenylation specificity factor 6 (CPSF6) is hypothesized to provide a significant fitness advantage to in vivo viral replication, explaining why CA-...
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#1Hideaki ShimizuH-Index: 18
#2Akatsuki Saito (Osaka University)H-Index: 14
Last. Tatsuo Shioda (Osaka University)H-Index: 37
view all 9 authors...
Dengue is a mosquito-borne viral infection that has spread globally in recent years. Around half of the world’s population, especially in the tropics and subtropics, is at risk of infection. Every year, 50–100 million clinical cases are reported, and more than 500,000 patients develop the symptoms of severe dengue infection: dengue haemorrhagic fever and dengue shock syndrome, which threaten life in Asia and Latin America. No antiviral drug for dengue is available. The dengue virus (DENV) non-st...
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#1Keita Suzuki (Osaka University)
#2Juthamas Phadungsombat (MU: Mahidol University)H-Index: 2
Last. Tatsuo Shioda (MU: Mahidol University)H-Index: 1
view all 12 authors...
Abstract Dengue is a mosquito-borne disease that has spread to >100 countries and is caused by the dengue virus (DENV), which belongs to the Flavivirus genus of the family Flaviviridae. DENV comprises 4 serotypes (DENV-1 to -4), and each serotype is further divided into distinct genotypes. In India, it is reported that all 4 serotypes of DENV co-circulate. Although Bangladesh is a neighboring country of India, very few reports have published DENV sequence data for the country, especially after 2...
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#1Akatsuki SaitoH-Index: 14
#1Keita Suzuki (Osaka University)
#2Emi E. Nakayama (Osaka University)H-Index: 22
Last. Tatsuo Shioda (Osaka University)H-Index: 1
view all 11 authors...
Dengue virus (DENV) infection is one of the biggest challenges for human health in the world. In addition, a secondary DENV infection sometimes causes dengue hemorrhagic fever (DHF), which frequently leads to death. For this reason, accurate diagnosis record management is useful for prediction of DHF. Therefore, the demand for DENV rapid diagnosis tests (RDTs) is increasing because these tests are easy and rapid to use. However, commercially available RDTs often show low sensitivity for DENV and...
1 CitationsSource
#1Tahmina SultanaH-Index: 2
Last. Tatsuo ShiodaH-Index: 1
view all 11 authors...
2 CitationsSource
#2Akatsuki SaitoH-Index: 14
Last. Masahiro YamashitaH-Index: 22
view all 10 authors...
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#1Akatsuki Saito (Osaka University)H-Index: 14
#2Hirotaka OdeH-Index: 20
Last. Tatsuo Shioda (Osaka University)H-Index: 1
view all 7 authors...
Abstract The HIV-1 capsid (CA) utilizes CPSF6 for nuclear entry and integration site targeting. Previous studies demonstrated that the HIV-1 CA C-terminal domain (CTD) contains a highly conserved K182 residue involved in interaction with CPSF6. In contrast, certain HIV-2 strains possess a substitution at this residue (K182R). To assess whether CA-CPSF6 interaction via the CA CTD is conserved among primate lentiviruses, we examined resistance of several HIV-1- and HIV-2-lineage viruses to a trunc...
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#1Douglas K. FischerH-Index: 1
#2Akatsuki SaitoH-Index: 14
Last. Zandrea AmbroseH-Index: 17
view all 7 authors...
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#1Emi E. Nakayama (Osaka University)H-Index: 22
#2Akatsuki Saito (Osaka University)H-Index: 14
Last. Siriphan Saeng-AroonH-Index: 5
view all 12 authors...
TRIM5α and MxB are known as restriction factors that inhibit the early step of intracellular HIV-1 replication cycle. Both factors are believed to interact with the incoming virus core to suppress HIV-1 infection. The extreme diversity of HIV-1 is thought to be a consequence of its propensity to mutate to escape immune responses and host restriction factors. We recently determined the capsid sequences for 144 HIV-1 CRF01_AE viruses obtained in Thailand from 2005 to 2011. In the present study, we...
3 CitationsSource
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