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Andrey Bogorodskiy
Moscow Institute of Physics and Technology
ChemistryCysteinyl leukotriene receptor 1ZafirlukastPranlukastBiology
8Publications
2H-index
17Citations
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Publications 10
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People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not excessive antifungal immune response that prevent fungal invasion. Intraepithelial dendritic cells (IE-DCs) of the conducting airway mucosa are located in the primary site of the inha...
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#1A. V. VlasovH-Index: 2
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This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural biology, biophysics, cells, and tissues imaging towards development of various medical diagnostic tools, drug design, and other medical applications. Classical and contemporary structural studies of different water-soluble and membrane proteins, DNA, RNA, and their interactions and behavior in different systems were analyzed in terms of applicability of RS techniques and their complementarity to other cor...
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#2Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 61
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#2Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 61
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#1Aleksandra Luginina (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Vadim Cherezov (SC: University of Southern California)H-Index: 61
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The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely prescribed as antiasthmatic drugs; however, these drugs demonstrate low effectiveness in some patients and exhibit a variety of side effects. To gain deeper understanding into the functional mechanisms of CysLTRs, we determined the crystal structu...
5 CitationsSource
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#1Ivan Maslov (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Andrey Bogorodskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Valentin Borshchevskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 11
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Research on halophilic microorganisms is important due to their relation to fundamental questions of survival of living organisms in a hostile environment. Here we introduce a novel method to stain halophiles with MitoTracker fluorescent dyes in their growth medium. The method is based on membrane-potential sensitive dyes, which were originally used to label mitochondria in eukaryotic cells. We demonstrate that these fluorescent dyes provide high staining efficiency and are beneficial for multi-...
2 CitationsSource
#1Marina Shevchenko (RAS: Russian Academy of Sciences)H-Index: 4
#2Andrey Bogorodskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Alexander M. Sapozhnikov (RAS: Russian Academy of Sciences)H-Index: 9
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Susceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mount primary bronchus specimens. Actin staining enab...
1 CitationsSource
#1Natalia V. Barykina (MIPT: Moscow Institute of Physics and Technology)H-Index: 4
#2Oksana M. Subach (MIPT: Moscow Institute of Physics and Technology)H-Index: 12
Last. Fedor V. Subach (MIPT: Moscow Institute of Physics and Technology)H-Index: 20
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Currently available genetically encoded calcium indicators (GECIs) utilize calmodulins (CaMs) or troponin C from metazoa such as mammals, birds, and teleosts, as calcium-binding domains. The amino acid sequences of the metazoan calcium-binding domains are highly conserved, which may limit the range of the GECI key parameters and cause undesired interactions with the intracellular environment in mammalian cells. Here we have used fungi, evolutionary distinct organisms, to derive CaM and its bindi...
7 CitationsSource
#1Andrey BogorodskiyH-Index: 2
#2Fedor FrolovH-Index: 1
Last. Valentin BorshchevskiyH-Index: 11
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Since the introduction of in meso crystallization of membrane proteins in lipidic cubic phase (LCP) by Landau and Rosenbusch in 1996, numerous studies attempted to elucidate the mechanism of in meso crystal nucleation and growth. Here we present a fluorescence microscopy study of the crystallization process of the light-driven proton pump bacteriorhodopsin. The crystallization starts with formation of microcrystals, followed by growth of a dominating crystal at the expense of smaller ones and fo...
6 CitationsSource
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