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Devang Mehta
University of Alberta
15Publications
4H-index
50Citations
Publications 15
Newest
#1Devang Mehta (U of A: University of Alberta)H-Index: 4
#2Alessandra Stürchler (Biotechnology Institute)H-Index: 2
Last.Hervé Vanderschuren (University of Liège)H-Index: 21
view all 7 authors...
Geminiviruses cause damaging diseases in several important crop species. However, limited progress has been made in developing crop varieties resistant to these highly diverse DNA viruses. Recently, the bacterial CRISPR/Cas9 system has been transferred to plants to target and confer immunity to geminiviruses. In this study, we use CRISPR-Cas9 interference in the staple food crop cassava with the aim of engineering resistance to African cassava mosaic virus, a member of a widespread and important...
6 CitationsSource
Publishers, reviewers and other members of the scientific community must fight science’s preference for positive results — for the benefit of all, says Devang Mehta. Publishers, reviewers and other members of the scientific community must fight science’s preference for positive results — for the benefit of all, says Devang Mehta.
Source
#1Devang Mehta (ETH Zurich)H-Index: 4
#2Matthias Hirsch-Hoffmann (ETH Zurich)H-Index: 15
Last.Hervé Vanderschuren (ETH Zurich)H-Index: 21
view all 8 authors...
We present a new method, CIDER-Seq (Circular DNA Enrichment sequencing) for the unbiased enrichment and long-read sequencing of viral-sized circular DNA molecules. We used CIDER-Seq to produce single-read full-length virus genomes for the first time. CIDER-Seq combines PCR-free virus enrichment with Single Molecule Real Time sequencing and a new sequence de-concatenation algorithm. We apply our technique to produce >1200 full-length, highly accurate geminivirus genomes from RNAi-transgenic and c...
2 CitationsSource
#1Zaïdi Syed-Shan-e-Ali (University of Liège)
#2Luc Cornet (University of Liège)H-Index: 4
Last.Hervé Vanderschuren (University of Liège)H-Index: 21
view all 5 authors...
#1Devang Mehta (U of A: University of Alberta)H-Index: 4
Source
#1Simon E. Bull (Biotechnology Institute)H-Index: 4
#2David Seung (ETH Zurich)H-Index: 11
Last.Hervé Vanderschuren (Gembloux Agro-Bio Tech)H-Index: 21
view all 11 authors...
Crop diversification required to meet demands for food security and industrial use is often challenged by breeding time and amenability of varieties to genome modification. Cassava is one such crop. Grown for its large starch-rich storage roots, it serves as a staple food and a commodity in the multibillion-dollar starch industry. Starch is composed of the glucose polymers amylopectin and amylose, with the latter strongly influencing the physicochemical properties of starch during cooking and pr...
16 CitationsSource
Senior academics must step up and take the lead in discussing intolerance, says Devang Mehta. Senior academics must step up and take the lead in discussing intolerance, says Devang Mehta.
Source
#1Devang Mehta (ETH Zurich)H-Index: 4
#2Alessandra Stürchler (ETH Zurich)H-Index: 2
Last.Hervé Vanderschuren (University of Liège)H-Index: 21
view all 5 authors...
We used CRISPR-Cas9 in the staple food crop cassava with the aim of engineering resistance to African cassava mosaic virus (a member of a widespread and important family of plant-pathogenic DNA viruses) by cleaving the virus9 replicative genome. We found that between 33 and 48% of edited virus genomes evolved a conserved single-nucleotide mutation that confers resistance to CRISPR-Cas9 cleavage. Our study highlights the potential for virus escape from this technology. Care should be taken to des...
2 CitationsSource
#1Devang MehtaH-Index: 4
Source
#1Ravi B. AnjanappaH-Index: 5
#2Devang MehtaH-Index: 4
Last.Hervé VanderschurenH-Index: 21
view all 6 authors...
Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) are responsible for significant cassava yield losses in eastern sub-Saharan Africa. To study the possible mechanisms of plant resistance to CBSVs, we inoculated CBSV-susceptible and CBSV-resistant cassava varieties with a mixed infection of CBSVs using top-cleft grafting. Transcriptome profiling of the two cassava varieties was performed at the earliest time point of full infection (28 days after grafting) in the su...
10 CitationsSource
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