Match!
Devang Mehta
ETH Zurich
10Publications
3H-index
24Citations
Publications 10
Newest
Published on Dec 1, 2019in Genome Biology14.03
Devang Mehta (U of A: University of Alberta), Alessandra Sturchler (Biotechnology Institute)+ 4 AuthorsHervé Vanderschuren20
Estimated H-index: 20
(University of Liège)
Geminiviruses cause damaging diseases in several important crop species. However, limited progress has been made in developing crop varieties resistant to these highly diverse DNA viruses. Recently, the bacterial CRISPR/Cas9 system has been transferred to plants to target and confer immunity to geminiviruses. In this study, we use CRISPR-Cas9 interference in the staple food crop cassava with the aim of engineering resistance to African cassava mosaic virus, a member of a widespread and important...
Published on Jan 25, 2019in Nucleic Acids Research11.15
Devang Mehta3
Estimated H-index: 3
(ETH Zurich),
Matthias Hirsch-Hoffmann12
Estimated H-index: 12
(ETH Zurich)
+ 5 AuthorsHervé Vanderschuren20
Estimated H-index: 20
(ETH Zurich)
We present a new method, CIDER-Seq (Circular DNA Enrichment sequencing) for the unbiased enrichment and long-read sequencing of viral-sized circular DNA molecules. We used CIDER-Seq to produce single-read full-length virus genomes for the first time. CIDER-Seq combines PCR-free virus enrichment with Single Molecule Real Time sequencing and a new sequence de-concatenation algorithm. We apply our technique to produce >1200 full-length, highly accurate geminivirus genomes from RNAi-transgenic and c...
Published on Oct 28, 2018
Zaïdi Syed-Shan-e-Ali (University of Liège), Luc Cornet3
Estimated H-index: 3
(University of Liège)
+ 2 AuthorsHervé Vanderschuren20
Estimated H-index: 20
(University of Liège)
Published on Oct 1, 2018in Nature plants13.30
Devang Mehta (U of A: University of Alberta)
Published on Sep 1, 2018in Science Advances
Simon E. Bull3
Estimated H-index: 3
(Biotechnology Institute),
David Seung9
Estimated H-index: 9
(ETH Zurich)
+ 8 AuthorsWilhelm Gruissem69
Estimated H-index: 69
(Biotechnology Institute)
Crop diversification required to meet demands for food security and industrial use is often challenged by breeding time and amenability of varieties to genome modification. Cassava is one such crop. Grown for its large starch-rich storage roots, it serves as a staple food and a commodity in the multibillion-dollar starch industry. Starch is composed of the glucose polymers amylopectin and amylose, with the latter strongly influencing the physicochemical properties of starch during cooking and pr...
Published on Jul 1, 2018in Nature43.07
Devang Mehta3
Estimated H-index: 3
Senior academics must step up and take the lead in discussing intolerance, says Devang Mehta. Senior academics must step up and take the lead in discussing intolerance, says Devang Mehta.
Published on May 4, 2018in bioRxiv
Devang Mehta3
Estimated H-index: 3
(ETH Zurich),
Alessandra Stürchler1
Estimated H-index: 1
(ETH Zurich)
+ 2 AuthorsHervé Vanderschuren20
Estimated H-index: 20
(University of Liège)
We used CRISPR-Cas9 in the staple food crop cassava with the aim of engineering resistance to African cassava mosaic virus (a member of a widespread and important family of plant-pathogenic DNA viruses) by cleaving the virus9 replicative genome. We found that between 33 and 48% of edited virus genomes evolved a conserved single-nucleotide mutation that confers resistance to CRISPR-Cas9 cleavage. Our study highlights the potential for virus escape from this technology. Care should be taken to des...
Published on Feb 1, 2018in Molecular Plant Pathology4.38
Ravi B Anjanappa4
Estimated H-index: 4
,
Devang Mehta3
Estimated H-index: 3
+ 3 AuthorsHervé Vanderschuren20
Estimated H-index: 20
Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) are responsible for significant cassava yield losses in eastern sub-Saharan Africa. To study the possible mechanisms of plant resistance to CBSVs, we inoculated CBSV-susceptible and CBSV-resistant cassava varieties with a mixed infection of CBSVs using top-cleft grafting. Transcriptome profiling of the two cassava varieties was performed at the earliest time point of full infection (28 days after grafting) in the su...
Published on Dec 1, 2017in BMC Genomics3.50
R. Glen Uhrig9
Estimated H-index: 9
(ETH Zurich),
Pascal Schläpfer1
Estimated H-index: 1
(ETH Zurich)
+ 2 AuthorsWilhelm Gruissem69
Estimated H-index: 69
(ETH Zurich)
Abstract Background Reversible protein acetylation occurring on Lys-N e has emerged as a key regulatory post-translational modification in eukaryotes. It is mediated by two groups of enzymes: lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) that catalyze the addition and removal of acetyl groups from target proteins. Estimates indicate that protein acetylation is second to protein phosphorylation in abundance, with thousands of acetylated sites now identified in different subcell...
12